| Term 
 
        | Presumptive Manifestations of Pregnancy: |  | Definition 
 
        | - Amenorrhea - N/V (2-12 weeks)
 - Breast changes
 - Quickening (16-20 weeks)
 - Urinary tract
 - Basal body temperature
 - Skin changes
 |  | 
        |  | 
        
        | Term 
 
        | Probable Manifestations of Pregnancy: |  | Definition 
 
        | - Pelvic Organs: Chadwicks sign (blue purple cervix b/c pelvic congestion), Leukorrhea, Hegar's sign (isthmus), Pelvic bones and ligaments - Abdominal enlargement
 - Contractions (Braxton Hicks 28 weeks and on)
 |  | 
        |  | 
        
        | Term 
 
        | Positive Manifestations of Pregnancy: |  | Definition 
 
        | - fetal heart tones - palpation (22 weeks)
 - ultrasound (5-6 weeks)
 - pregnancy test: urine, serum (quantitative,qualitative)
 |  | 
        |  | 
        
        | Term 
 
        | Beta-hcG is produced days after fertilization. It is detected in maternal serum ___ days after ___. It ___ every 1-2 days. It peaks at ___ weeks. |  | Definition 
 
        | - 8-11 days after conception - doubles every 1-2 days
 - peaks at 10-12 weeks
 |  | 
        |  | 
        
        | Term 
 
        | Beta hcG decreases in the __ and __ __. |  | Definition 
 
        | second and third trimesters |  | 
        |  | 
        
        | Term 
 
        | hcG is low in __ or __ abortions. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | hCG is high with __ or __ __. |  | Definition 
 
        | twins or trophoblastic disease |  | 
        |  | 
        
        | Term 
 
        | Average gestational duration: |  | Definition 
 
        | - 40 weeks= 280 days= 10 lunar months 
 OB wheel
 Nagele's Rule
 Calculators
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | EDC= [(LMP + 7 days) - 3 months] + 1 year |  | 
        |  | 
        
        | Term 
 
        | The uterus becomes palpable at __ weeks. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | FIGURE OUT IF WE NEED TO KNOW WHATS HAPPENENING EACH WEEK/MONTH OF PREGNANCY. SKIPPED THIS WHEN MAKING CARDS. SLIDES 16-23 OF SELF STUDY PREGNANCY POWERPOINT. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Expected changes in pregnancy: |  | Definition 
 
        | Weight Skin/Connective Tissue
 Breast
 Cardiovascular
 Gastrointestinal
 G/U
 Other
 |  | 
        |  | 
        
        | Term 
 
        | Weight changes with pregnancy: |  | Definition 
 
        | Additional pregnancy energy demands an estimated extra 300 kcal/day Increase in weight attributable to:
 the uterus
 uterine contents (fetus and placenta account for approx. 9 lbs)
 increase in blood volume
 extracellular fluid
 (lesser so to cellular water and deposition of fat and protein)
 Average amt of extra water retained is about 6.5L
 3.5L in uterus
 3.0L in blood volume and breasts
 Average weight gain 27.5 lbs
 Recommended weight gain 25-35 lbs
 |  | 
        |  | 
        
        | Term 
 
        | Cardiovascular changes with the heart include increased ___ __ by __ to __ weeks (40-45% increase). Systemic vascular resistance ___. Heart rate __ by ___. This all results in an increased ___. Later in pregnancy, when supine, the large uterus can impede cardiac venous return. |  | Definition 
 
        | - cardiac output by 20-24 weeks - resistance decreases
 - increases by 10 bpm
 - increased preload
 |  | 
        |  | 
        
        | Term 
 
        | A __ murmur is present in 90% of pregnant women. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | During pregnancy it is normal to have increased __ __ size, so that the PMI is ___ displaced. |  | Definition 
 
        | - increased left ventricular size - laterally displaced
 |  | 
        |  | 
        
        | Term 
 
        | During pregnancy there is a 50% blood volume increase. Also all the estrogen stimulates the RAS system which increases ___ causing __ and __ resportion. |  | Definition 
 
        | - aldosterone - sodium and water
 |  | 
        |  | 
        
        | Term 
 
        | Blood Pressure: Affected primarily by posture
 ↓ BP by 6-10 mmHg during pregnancy
 ↑ BP at end of pregnancy
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Rise in venous pressure to pelvis and LE’s leads to: Dependent pedal edema
 Varicose veins in legs and vulva
 Hemorrhoids
 ↑ risk of thrombosis in lower extremities due to said stagnation
 ↑ in venous pressure below level of uterus and ↓ interstitial osmotic pressure often results in pedal edema late in pregnancy
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Blood Red cells increase by 33%
 Increase in plasma volume accounts for anemia of pregnancy
 Increased utilization of iron
 WBC’s increase
 4.5-4.5 prepregnant average
 5-12 in third trimester on average
 Platelets decrease below 150 in 6% of pregnancies
 ↑ in concentrations of all clotting factors
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Kidneys Enlarge ~ 1-2cm in length
 GFR ↑ by 40-65%
 Renal plasma flow also increases
 Renal pelvis dilates
 BUN and Cr levels decrease
 Creatinine clearance increases by 30%
 Proteinuria and hematuria are not normal (except at delivery)
 Protein loss should not exceed 300 grams/24 hours
 Mild glucosuria can be normal but suspicion of GDM should not be ignored
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | during prregnancy BUN and creatinine levels ___ and creatinin clearance ___ by 30%. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Creatinine clearance increases (best test of kidney function in pregnancy) Creatinine clearance increases (best test of kidney function in pregnancy)
 Creatinine clearance increases (best test of kidney function in pregnancy)
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the best test of kidney function in pregnancy? |  | Definition 
 
        | creatinine clearance (increases 30% with pregnancy) |  | 
        |  | 
        
        | Term 
 
        | Urine is checked for __ and __ at every OB visit. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | During pregnancy,what happens to liver size? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Gallbladder contractility is reduced
 results in increased residual volume and stasis
 along with cholesterol increase during pregnancy, this leads to increased prevalence of cholesterol stones
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Colon displaced laterally and superiorly
 hypoperistalsis = constipation
 appendix displaced upward and laterally
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Lower quad. pain Differentiate round ligament pain with UTI, constipation, appendicitis, etc.
 Hemorrhoids are very common due to
 Constipation
 Elevated venous pressure in LE’s
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Chloasma or Melasma – brown patches Diastasis Recti (yes, the picture below left is of a man)
 Striae gravidarum
 Linea nigra (linea alba in nonpregnant state)
 Angiomas
 Palmar erythema (2/3 white women; 1/3 black women)
 Cutis marmorata (mottling)
 Nails become brittle
 Hair thickens (caused by increased number of follicles)
 http://www.gynaeonline.com/images/stria.jpg
 http://bader-gottlieb.net/pregnant/Dec_7a.jpg
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Connective tissue of the reproductive tract remodels Cervix softens
 Progressive lordosis
 Increased joint mobility of:
 Sacroiliac
 Sacrococcygeal
 Pubic
 The mobility not correlated with maternal estradiol, progesterone, or relaxin levels
 Therefore:
 increased back pain
 “waddle” gait
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Breasts enlarge 2-3 x prepregnancy size - hyperplasia of breast tissue
 - tenderness and tingling noticed in early weeks
 - after 2nd month breasts increase in size
 ↑ fullness, tingling, tenderness, nodular
 Tissue softer and looser
 Striae
 ↑ Mammary vascularization
 Colostrum
 accumulates in the alveoli
 colostrum crust on the nipple
 Areolae - ↑diameter, darker, erectile
 Montgomery glands are more prominent (hypertrophic sebaceous glands of areolae)
 Gigantomastia: life threatening breast enlargement
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Uterus: Nonpregnant uterus: 70g (capacity of 10mL)
 Uterus at end of pregnancy: 1100g (capacity of 5L to 20L)
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Cervix: At 1 month, cervix undergoes softening and cyanosis due to increased vascularity and edema
 A major component of the cervix is connective tissue helping
 Cervical glands undergo hypertrophy and hyperplasia
 As a result, cervical secretions increase considerably
 The vagina undergoes changes, too:
 Considerable increase in thickness of the mucosa
 Loosening of connective tissue
 Hypertrophy of smooth muscle
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Endocrine: Pituitary gland enlarges with ensuing hormone fluctuations
 Prolactin (lactation)
 Growth hormone
 Thyroid enlarges
 Increased TBG
 Stimulated by placenta
 Decreased iodine availability
 Hypothyroidism common in pregnancy
 Investigate goiters!!!
 Parathyroid hormone decreases in response to increase in serum calcium
 Adrenal glands undergo little change; hormones slightly increased if anything
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Neuro: Memory decline often reported
 Difficulty going to sleep
 Frequent awakenings
 Fewer hours of sleep
 Reduced sleep efficiency
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Uterine Size (FHR after 8 wks trans-vaginally, after 12 weeks trans-abdominally) |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | READ ABOUT GENETIC DISORDERS IN BOOK |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Fetal heart rate is detectable after 8 weeks ___ or after 12 weeks ___. |  | Definition 
 
        | - transvaginally - transabdominally
 |  | 
        |  | 
        
        | Term 
 
        | The fundal height is measured from the __ __ to the __ __. The fundus should be at the umbilicus at __ weeks (most accurate 20-30 weeks). __ cm/week is expected. |  | Definition 
 
        | - from the symphisis pubis to the superior pubis - at the umbilicus at 20 weeks
 
 Larger = multiple, GDM
 Smaller = IUGR
 - 1 cm/week
 |  | 
        |  | 
        
        | Term 
 
        | Watch for: obesity
 amniotic fluid amount
 myoma (uterine fibroid)
 multiple gestations
 fetal size
 uterine position
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Heart sounds can first be heard with the doppler at __ weeks. Heart sounds are first heard with the fetoscope at __ weeks. Normal is ___ bpm. |  | Definition 
 
        | - 9 weeks with the doppler - 15-16 weeks with the fetoscope
 - 120-160 bmp
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 1. Using two hands and compressing the maternal abdomen, a sense of fetal direction is obtained (vertical or transverse). 2. The sides of the uterus are palpated to determine the position of the fetal back and small parts.
 3. The presenting part (head or butt) is palpated above the symphysis and degree of engagement determined
 4. The fetal occipital prominence is determined.
 |  | 
        |  | 
        
        | Term 
 
        | Do a pelvic exam at ___ weeks to determine pelvic shape. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Early signs of pregnancy detected between 6 and 14 weeks: |  | Definition 
 
        | - Goodell: softening of the cervix at 4-6 weeks (cervix feels like lips instead of nose) - Hegar sign: softening of the uterine isthmus at 6-8 weeks
 - Chadwick sign: vascular congestion and bluish purple  color of vagina/cervix, 8-12 weeks
 - McDonald sign: fundus flexes easily on the cervix, 7-8 weeks
 - Von Fernwald: fullness and softening of the fundus at the implantation site, 7-8 weeks
 |  | 
        |  | 
        
        | Term 
 
        | Initial blood screens in pregnancy: |  | Definition 
 
        | - Blood type (Rh+ or Rh-) - CBC (hemoglobin)
 - Rubella Ab
 - Pap test
 - STDs: G&C, RPR, HIV, Hep B&C)
 - PPD in high risk individuals
 |  | 
        |  | 
        
        | Term 
 
        | Maternal blood type is performed to prevent the potentially fatal disease of the newborn called ___ ___ and ___ __  of the newborn. This results in __ and __ __. |  | Definition 
 
        | - fetal erythroblastosis and hemolytic disease of the newborn (hydrops fatalis, enlarged abdomen and liver) - anemia and heart failure
 |  | 
        |  | 
        
        | Term 
 
        | Rh Negative 15% of the US population is Rh negative
 When to be concerned
 If MOB’s blood type is Rh negative
 Baby's blood type COULD BE Rh positive (inherited from the father)
 MOB may make antibodies (immunoglobulin G [IgG]) that can cross over the placenta into the baby's blood stream and attack the baby's red blood cells.
 Sensitization can occur at any time:
 Spontaneous abortion
 Bleeding during pregnancy
 At delivery
 First pregnancy – no problems
 Subsequent pregnancies are at risk
 Give RhoGAM (Rh immunoblobulin)
 prevents the mother from forming antibodies
 Given at 28 weeks and at delivery
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is RhoGAM and when is it given? |  | Definition 
 
        | - RhoGAM is Rh immunoglobulin that prevents the Rh negative mother from forming antibodies to her baby's Rh positive blood - given at 28 weeks and at delivery
 |  | 
        |  | 
        
        | Term 
 
        | Rubella is aka __ __. Congenital Rubella Syndrome (CRS) can cause: |  | Definition 
 
        | - German measles - growth retardation
 - malformations of the heart, eyes, or brain
 - deafness
 - liver, spleen, and bone marrow problems
 - characteristic blueberry muffin appearance= thrombocytopenia purpura
 |  | 
        |  | 
        
        | Term 
 
        | Rubella causes baby to have __ __. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | At __to __ weeks you do the triple/quad/penta screen. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What 4 things do the quad and penta screens include? |  | Definition 
 
        | - hCG - Unconjugated estriol (uE3)
 - Alpha feto protein (AFP)
 - Dimeric inhibin A (DIA)
 
 (HUAD)
 -
 |  | 
        |  | 
        
        | Term 
 
        | The triple/quad/penta screen is NOT mandatory but should be offered to all pregnant women. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | The triple/quad/penta screen is a screen not ___. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What does the penta screen have that the quad screen does not? |  | Definition 
 
        | Invasive trophoblast Antigen (ITA) |  | 
        |  | 
        
        | Term 
 
        | The results of quad screen are based on __ __. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Elevated AFP may indicate what 3 things? |  | Definition 
 
        | - baby is further along that originally thought - twins
 - neural tube defect
 |  | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | Low estriol indicates what? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | what three things are included in the triple screen |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Chorionic villus sampling is offered at __ to __ weeks. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Chorionic villus sampling (CVS) Performed at 10-12 weeks
 Transabdominal or transcervical
 Complication of rate of <1%
 Essentially a biopsy of the placenta
 After 14 weeks, the amount of amniotic fluid makes procedure difficult
 Can diagnose
 Tay-Sachs Disease
 Hemophilia
 Down’s syndrome
 Cannot diagnose
 Neural tube defects
 Lung maturity
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | chorionic villus sampling should not be done after __ weeks. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Amniocentesis is offered at __ to ___ weeks. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Amniocentesis Offered at 15-20 weeks
 Complication rate <1%
 Amniotic fluid contains fetal skin cells and hormones
 Can detect
 Chromosomal abnormalities
 Neural tube defects
 Fetal lung maturity (3rd trimester)
 Infection
 Cannot detect
 Birth defects like cleft palate, club feet, etc
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | what chance of amniocentesis have of terminating a pregnancy? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Pregnant women should be screened for GDM between __ and __ weeks. Give a __g __ hour glucose tolerance test. If greater than __, do more workup. Check __ __ __ and then do a __ gram __ hour glucose tolerance test where you check bs at __,__, and __hours. If any two of these are positive, __ is diagnosed. |  | Definition 
 
        | - 24 and 28 weeks - 50 gram 1 hour glucose tolerance test
 - 130
 - fasting blood glucose
 - 100 gram 3 hour glucose tolerance test
 - 1,2, and 3 hours
 - GDM
 |  | 
        |  | 
        
        | Term 
 
        | Diet controlled GDM is called: |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | Gestational DM continued: |  | Definition 
 
        | Frequent BS testing Fasting am
 1 hour after meals
 NST/BPP’s
 Twice weekly starting at 32 weeks
 Maternal monitorin (kick counts)
 Risks of:
 Bactiuria
 Thyroid disease
 Edema
 Preeclampsia
 Preterm labor
 LGA
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | - bactiuria - thyroid disease
 - edema
 - preeclampsia
 - preterm labor
 - LGA
 |  | 
        |  | 
        
        | Term 
 
        | Screening for Group B streptococcus occurs at __ to __ weeks. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Group B Streptococcus (GBS) Streptococcus agalactiae (beta-hemolytic streptococci.)
 Tested from cervix, vagina, rectum, or vaginal introitus
 Cause of potentially dangerous maternal and fetal infections
 Neonatal sepsis, pneumonia, meningitis
 Maternal Metritis
 Risks
 premature delivery
 prolonged rupture of membranes
 fever while in labor
 positive cultures for GBS during pregnancy
 Who to treat
 Presentation during preterm labor
 History of positive culture for GBS during pregnancy
 Spontaneous, premature membrane rupture
 Membrane rupture for longer than 18 hours
 Presentation with fever
 History of previous delivery of a newborn with GBS disease
 Treatment is IV PCN or Amp and 48 hours Obs of baby
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Treatment of group B strep is : |  | Definition 
 
        | - IV penicillin or ampicillin - 48 hour observation of baby
 |  | 
        |  | 
        
        | Term 
 
        | Umbilical cord blood storage Collected at delivery
 large number of hematopoietic progenitor cells
 can be used as a source of stem cells for treatment of hematological disorders and malignancies.
 saving cord blood for many years is extremely costly.
 odds of needing a stem cell transplant are low—estimated at between 1 in 1000 and 1 in 200,000 by age 18 years.
 ACOG believes that many questions about this technology remain unanswered and asks that parents should not be sold this service without a realistic assessment of their likely return on the investment.
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | The best counseling is preconception counseling PNV’s
 Maternal age
 Vaccinations
 Smoking/EtOH cessation
 Risk factors
 FHx and Genetic Hx
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | 25-35 pound weight gain Weight loss not recommended
 Average woman (acc to CMDTOG)
 2300 kcal/day
 +300 during pregnancy
 +500 during breastfeeding (800 extra total)
 Protein is essential
 Vitamins and minerals (begin 1-3 months prior to pregnancy)
 Folic acid
 Calcium and iron
 |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | Organism Listeria monocytogenes
 food born or found in veterinary clinics
 loves refrigerator temperatures
 Symptoms
 mild to more moderate gastrointestinal
 illness with nausea, vomiting, and diarrhea
 can cause fetal damage or miscarriage
 |  | 
        |  | 
        
        | Term 
 
        | To avoid listeriosis,  what should a pregnant woman avoid? |  | Definition 
 
        | - unpasteurized milk - soft cheeses (feta, brie, Camembert, Roquefort, blue veined, or mexican style)
 - cold meats, pates, or meat spreads
 - undercooked or raw animal foods like meat, fish, shellfish, or eggs
 - refrigerated smoked seafood (canned versions are okay)
 - wash all fruits and vegetables thoroughly
 - reheat until steaming hot dogs, sausages, and luncheon meats
 |  | 
        |  | 
        
        | Term 
 
        | Cook properly Ground beef should be cooked to at least 160°F, roasts and steaks to 145°F, and whole poultry to 180°F.
 Eggs should have a firm yolk and white after cooking.
 Eggnog and hollandaise sauce have raw or partially cooked eggs and are not considered safe.
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Moderate intake of fish consumption  (exposure to mercury) Tuna, shark, swordfish, king mackerel, and tilefish
 8-12 ounces per week (FDA, EPA)
 Some sources say once per week no matter the fish
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Caffeine during pregnancy: |  | Definition 
 
        | Right now sources say to avoid it Definitely no more than 1-2 servings/day
 Nervous system stimulant that is found in many plants and is present in many foods
 Increases blood pressure and heart rate
 Stimulates urination; may cause dehydration
 Some studies speculate increase the risk of miscarriage
 |  | 
        |  | 
        
        | Term 
 
        | If pregnant woman is smoking what drug can you give her to help her stop? What drug is CONTRAINDICATED for this purpose? |  | Definition 
 
        | - can give her Wellbutrin - CANNOT give her Chantix
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | - Category A: no fetal risk - Category B: Animal studies show no fetal risk, no studies in women
 - Category C: Animal studies show adverse fetal effects, no studies in women
 - Category D: some fetal risk, benefits may outweigh risks
 - Category X: fetal risk not outweighed by benefit, contraindicated
 |  | 
        |  | 
        
        | Term 
 
        | What is the only antihypertensive class of medications that is contraindicated in pregnancy? |  | Definition 
 
        | LOOK THIS UP 
 I think its ACE inhibitors (prils)
 |  | 
        |  | 
        
        | Term 
 
        | Exercise during pregnancy: |  | Definition 
 
        | May reduce complications May affect labor to be shorter, easier, better newborn health and higher IQ of newborn
 Usually low impact exercise (pulse <140bpm)
 If a prepregnant woman already participating in an exercise program, continue with minor alterations.
 Restriction may be necessary if bleeding, premature labor, or have other high-risk concerns.
 Don’t start new exercise programs in pregnancy
 Walking and swimming often considered the best
 Avoid sports where prone to injury
 |  | 
        |  | 
        
        | Term 
 
        | Intercourse during pregnancy: |  | Definition 
 
        | Not considered abortifacient Late in pregnancy, may induce contractions (orgasm)
 “pelvic rest” considered in patients with previous premature delivery and incompetent cervix
 |  | 
        |  | 
        
        | Term 
 
        | Vaccinations during pregnancy must be __, __, or ___. Avoid live attenuated vaccines. |  | Definition 
 
        | - killed, toxoid, or recombinant |  | 
        |  | 
        
        | Term 
 
        | Dental visits Gum hypertrophy normal
 Normal procedures okay
 Periodontal disease associated with preterm birth
 |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | 10 kicks in 2 hours is good |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | - 2 fetal accelerations at least 15 bpm above baseline for at least 15 seconds |  | 
        |  | 
        
        | Term 
 
        | Biophysical Profile (BPP) considers what factors: |  | Definition 
 
        | - NST - fetal breathing movements
 - fetal movement
 - fetal tone
 - Amniotic fluid volume
 
 2 points for each, so possible score of 10
 |  | 
        |  | 
        
        | Term 
 
        | DDx of bleeding in the first trimester: |  | Definition 
 
        | Implantation bleeding Common
 minimal bleeding at about the time of the first missed menstrual period and generally lasts a very short time
 may be present for 1 to 2 days, with a flow similar to that of a menstrual period
 20% to 25% of all pregnant women spot or bleed in the first trimester
 OR:
 threatened, inevitable, complete, or incomplete abortion
 ectopic pregnancy
 molar pregnancy
 |  | 
        |  | 
        
        | Term 
 
        | Risk factors for ectopic pregnancy: |  | Definition 
 
        | - nonwhite race - older age
 - h/o STD/PID
 - infertility treatment
 - IUD
 - BTL or tubal repair
 - previous ectopic pregnancy
 - DES exposure
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | Severe, sharp constant pain at affected side more diffuse abdominal pain with intraperitoneal hemorrhage
 shock may be present (hypovolemia due to hemorrhage)
 +/- cervical motion tenderness
 +/- vaginal bleeding (Ectopic pregnancies cause vaginal bleeding because of the separation of the decidua from the endometrium as the ectopic pregnancy dies )
 Diagnostics:
 bHCG for all women of childbearing ages (10–55)
 U/S, preferably transvaginal (determine intratuterine vs. ectopic)
 Culdocentesis (to determine if in fact it is hemorrhage)
 VERY BAD:
 Intraperitoneal hemorrhage
 infection
 |  | 
        |  | 
        
        | Term 
 
        | A __ __ allows you to see if pregnancy is ectopic or uterine. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | ___ lets you see if there is hemorrhage with ectopic pregnancy. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | 83% of ectopic pregnancies are ampullary |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Threatened Ab bleeding observed and the cervix is closed
 appropriate uterine size
 +/- uterine tenderness
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Complete Ab the uterus has expelled its contents
 cervical os is closed, bleeding is minimal, and the uterus is near normal size
 little or no uterine pain or cramping unless a uterotonic agent is used such as ergonovine maleate (Ergotrate) or methylergonovine maleate (Methergine)
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Incomplete Ab part of the products of conception have been expelled but some remains within the uterus
 cervix is generally dilated, there is usually bleeding (may be profuse)
 uterus is generally enlarged
 uterine cramping and pain
 more common at > 6 wks gestation
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Missed Ab embryo dies but the products of conception are not expelled from the uterus
 uterus involutes so that it is smaller than expected by dates
 dark red or brown vaginal bleeding, often minimal in amount
 pregnancy tests may remain positive for quite some time in the face of a missed abortion
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Septic Ab: Infection occors concurrently with Ab
 Temperature elevation; elevated WBC and ESR
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Most trophoblastic tumors are __ __. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Symptoms of trophoblastic disease: |  | Definition 
 
        | - vaginal bleeding - enlarged uterus beyond the size expected for gestational age
 - may pass grape-like structures
 - hypertension
 - edema
 - proteinuria
 |  | 
        |  | 
        
        | Term 
 
        | Diagnostics for trophoblastic disease: |  | Definition 
 
        | - elevated hcG > 100,000 - ultrasound
 |  | 
        |  | 
        
        | Term 
 
        | Molar pregnancies are suggested by vaginal bleeding, uteri larger than gestational age, and serum hCG levels of 100,000 mIU/ml or greater |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Other causes of abnormal vaginal bleeding coagulopathies
 blood dyscrasias
 endocrinopathies
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | HTN in pregnancy is bp of 140/90. Treatment is indicated at ___, usually ___. ___ are contraindicated. Most __ are NOT recommended. Fetal monitoring at ___ weeks. |  | Definition 
 
        | - 160/100 - Labatolol
 - ACE_I
 - diuretics
 - 34-36 weeks
 |  | 
        |  | 
        
        | Term 
 
        | 2 criteria for preeclampsia: |  | Definition 
 
        | PIH (140/90 or higher) + proteinuria |  | 
        |  | 
        
        | Term 
 
        | Signs and Symptoms of preeclamsia: |  | Definition 
 
        | - Scotomata - Intractable headaches
 - RUQ pain
 - hyperreflexia or clonus
 |  | 
        |  | 
        
        | Term 
 
        | Labs expected with preeclampsia: |  | Definition 
 
        | - elevated uric acid - elevated Hb
 - elevated liver function test
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | - preeclampsia + seizures |  | 
        |  | 
        
        | Term 
 
        | HELLP syndrome is a severe complication of ___. What does  it stand for? |  | Definition 
 
        | - severe complication of preeclampsia - Hemolysis
 - Elevated Liver enzymes
 - Low Platelets
 |  | 
        |  | 
        
        | Term 
 
        | HELLP syndrome occurs in 10% of preeclampsia and 50% of eclampsia. __ may be helpful. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Placenta previa is a complication of the 3rd trimester, but can also occur as early as 20 weeks. There is __ __ blood in the vagina. |  | Definition 
 
        | - bright red blood - Instrumentation, digital examination of the cervix, and speculum examination can provoke severe, exsanguinating hemorrhage
 can occur at 20 weeks' gestation (1/3 of PP cases are <30wks)
 admission and obstetric consultation are indicated
 |  | 
        |  | 
        
        | Term 
 
        | Abruptio Placentae often has __ __ __ and __ in the vagina. This ranges in severity and amount of bleeding does not correlate to severity. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Most common cause of intrapartum fetal death: |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Previa is ___, Abrupto placentae is __ __. |  | Definition 
 
        | - Previa is painless - Abrupto placentae is very painful
 |  | 
        |  | 
        
        | Term 
 
        | Abrupto placentae is associated with __. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Monitoring for abrupto placentae: |  | Definition 
 
        | U/S, fetal monitoring, fibrin and platelet count |  | 
        |  | 
        
        | Term 
 
        | round ligament pain is more common on the __ side. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Round ligament pain Refers to a type of pelvic pain caused by stretching of the round ligaments (more common on the right than the left)
 Etiology
 Two thick ligaments (the round ligaments) hold the uterus in suspension within the pelvis and abdomen; during pregnancy, these ligaments become long and thin like rubber bands
 Ligaments pull on nearby nerve fibers causing pain, usually sharp pain
 Can awaken a patient from sleep after rolling over
 Can be brought on by exercise
 Pain often eases as pregnancy progresses
 Treatment
 Applying heat to the area may relieve pain:
 Hot soaks
 A heating pad
 A hot bath
 Lying on the opposite side
 Moving gradually rather than suddenly
 Tylenol (acetaminophen)
 |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Premature labor is defined as __ __ with __ __ before __ weeks. This is the leading cause of neonatal mortality. Occurs in 8-10% of all pregnancies. |  | Definition 
 
        | - uterine contractions with cervical changes before 37 weeks |  | 
        |  | 
        
        | Term 
 
        | Risk factors for preterm delivery: |  | Definition 
 
        | - Lower SES - Extremes of age
 - tobacco or cocaine use
 - h/o preterm delivery
 - infections (UTI, genital, etc.)
 |  | 
        |  | 
        
        | Term 
 
        | Diagnostics for preterm labor: |  | Definition 
 
        | - fetal monitoring - ultrasound
 - fetal fibronectin (fFN)
 |  | 
        |  | 
        
        | Term 
 
        | ___ like __ __ and __ __ such as __ and __ can prolong gestation if the fetus is viable and the mother is healthy. |  | Definition 
 
        | - Tocolytics like magnesium sulfate - B-mimetics such as Terbutaline and Ritodrine
 |  | 
        |  | 
        
        | Term 
 
        | Criteria for delivery when preterm labor is occuring: |  | Definition 
 
        | - maternal illness: Eclampsia (PIH, proteinuria, grand mal seizures) - fetal demise
 - congenital anomalies
 |  | 
        |  | 
        
        | Term 
 
        | PROM is aka ____. Avoid digital examination of cervix. |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | Nitrazine paper testing reveals a pH of 7.1 to 7.3 typical of amniotic fluid (normal vaginal pH in pregnancy is 3.5 to 6.0) Ferning: when amniotic fluid turns white and crystallizes on a slide after heating
 Vaginal secretions caramelizes and turns brown after heating on a slide
 Cultures for group B streptococci, Chlamydia, and gonorrhea should be obtained.
 |  | 
        |  | 
        
        | Term 
 
        | Third trimester bleeding Placenta previa
 Placental abruption
 Uterine rupture
 |  | Definition 
 | 
        |  |