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Neoplasia 4
Pathogenesis of Neoplasia
10
Veterinary Medicine
Not Applicable
03/15/2017

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Cards

Term
What does p53 do?
Definition
tumor suppressor gene that promotes apoptosis in cells with DNA damage
Term
What does PTEN do?
Definition
neutralizes the effects of receptor kinases
Term
Feline leukemia virus is associated with (B cell / T cell) lymphopmas
Definition
T cell
Term
Feline sarcoma virus (FeSV) is....
Definition
mutant form of FeLV carrying fos (a proto-oncogene)

-virus transforms rapidly
Term
Why is inflammation a risk factor for neoplasms?
Definition
-tissue repair = chronically replicating cells, and lots of leukocytes present which produce free radicals that are mutagenic
Term
What is the difference between mutagenic & non-mutagenic carinogens?
Definition
mutagen: clearly generates the precursor for carcinogenesis

non-mutagenic: increase cell proliferation in some way (e.g. inflammation, cause necrosis etc)
Term
Characteristics of cancer stem cells
Definition
-low proliferation rate
-low uptake of drugs
-can self-renew & produce daughtere cells
-express stem cell markers
Term
What role does telomerase play in cancer cell survival?
Definition
expression of telomerase allows the cells to add back missing bits of telomeric DNA, to maintain telomere length

(short telomere = short lifespan)
Term
Most cancer mortality is due to ____
Definition
metastasis
Term
Avian leukosis virus (ALV) increaes expression of ______ which leads to bursal lymphoma
Definition
c-myc
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