Term
| Causes gingivostomatitis, keratoconjunctivitis, temporal lobe encephalitis |
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Definition
HSV-1
Can also cause genital herpes, but mostly around the lips
Lies dormant in sensory neurons, in trigeminal neurons |
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Term
| When immune system lets down gaurd, usually causes painful vesicles in genital regions. |
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Definition
HSV-2
Transmission via genital/mucosal contact. All it takes is some intimate contact.
Babies can be at risk when born through infected vaginal canal. |
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Term
Primary infection causes chicken pox
Secondary infection leads to shingles |
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Definition
Human Herpes virus 3:
Varicella Zoster Virus (VZV)
Transmitted through respiratory secretions
Becomes latent in the Dorsal Root Ganglion. Group vesicles correspond into a single dermatone |
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Term
Herpes vesicle tissue spread on slide, applied stain with tzanck test. What is seen?
Infected cells are seen with? |
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Definition
Multinucleated giant cells
intranuclear Cowdry A inclusions |
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Term
| Causes infectious mononucleosis. Infects B cells and causes posterior cervical lymphadenopathy |
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Definition
Epstein Barr virus
Causes atypical lymphocytosis (Downey cells) which are T cells that look weird and have foamy appearance |
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Term
| EBV monospot detects what? |
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Definition
heterophile antibodies detected by agglutination of sheep RBC. (cold agglutins)
(Produces antibodies that for some reason like to agglutinate sheet blood) |
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Term
| EBV associated with what neoplasms? |
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Definition
Hodgkin and Burkitt lymphomas
and nasopharyngeal carcinoma!
Remains latent inside body after acute infection |
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Term
| Commonly spread congenitally, infected bodily fluids (saliva and breast milk). A part of the TORCH infections |
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Definition
Human Herpes virus 5:
Cytomegalovirus |
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Term
| Owls eye inclusions in histology |
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Definition
Cytomegalovirus
Can cause blindness in HIV patients |
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Term
| Children with 3-5 days of high fever. Fever breaks and then child gets head to toe rash. |
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Definition
Human Herpes virus 6:
Roseola (erythema infectiosum) |
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Term
Associated with HIV and more common in homosexual men
Highly vascular tumor of spindle cells (purplish appearance) |
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Definition
Human Herpes Virus 8:
Kaposi sarcoma
Can experience hemoptysis because
can also see a nodule on Xray.
These tumors can be aggressive and lethal |
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Term
| Guanosine analog. First monophosphorylated by viral thymidine kinase. Phosphorylated to triphosphate active form that is incorporated into viral DNA |
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Definition
Acyclovir
Used for:
HSV
VZV
EBV
Start as soon as possible |
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Term
CMV does not use the same thymidase kinase as
Inhibits viral DNA polymerase |
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Definition
Ganciclovir
Used for CMV infections
Toxicity:
Bone marrow suppression, renal toxicity (inc BUN) |
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Term
Inhibits viral DNA pol II and binds to pyrophosphate binding site.
Does not require activation by viral kinase. |
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Definition
Foscarnet
Especially good for viruses that have HSV or CMV is not responding due to mutation in the gene for viral Thymidine kinase
Does NOT cause bond marrow suppression |
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Term
| Uses reverse transcriptase to make DNA from RNA intermediate |
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Definition
HBV
Spread perenteral and sexual route |
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Term
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Definition
Acute: Malase, anorexia, nausea vomiting and RUQ pain. Appear jaundiced
Chronic: Can spread disease to other people, and can lead to cirrhosis and Hepatocellular carcinoma (Carrier, cirrhosis, HCC) |
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Term
| Single stranded RNA virus, transmitted via blood transfusions |
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Definition
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Term
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Definition
Interferon alpha
ribiviron |
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Term
| Uses HBV surface antigen for surface envelope. Use the same route of transmission |
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Definition
HDV
Usually infects simutaneously or superinfection of HBV |
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Term
Fecal-oral transmission
Picorna RNA virus |
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Definition
HAV
Asymptomatic in young children, more symptomatic in older individuals
Does not cause chronic infection, and resolves. |
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Term
Fecal-oral transmission
Transmitted enterically and causes water-borne epidemics |
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Definition
HEV
High mortality rate when it infects pregnent women. Causes fulminant hepatitis |
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Term
| Double stranded DNA virus causing conjunctivitis |
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Definition
Adenovirus
Febrile pharyngitis
Acute hemorrhagic cystitis
Pneumonia
Diarrhea |
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Term
| Single stranded DNA virus. Small virus that causes transient aplastic episode in sickle cell patients |
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Definition
Parvovirus B19
Also causes fifth's disease which causes "slapped cheek disease". Can also cause hydrops fetalis if its transmitted in utero
In adults, it resembles arthritis that resembles rheumatoid arthritis |
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Term
Types 1 and 2 cause
Types 6 and 11 cause genital warts
Types 16 and 18 cause cancer |
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Definition
HPV
16-18 cause cervical, vulvular, penile squamous cell carcinoma |
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Term
| Progressive multifocal leukoencephalopathy in HIV patients |
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Definition
Polyomavirus family:
- JC Virus |
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Term
| Enveloped virus eradicated from earth. but concerned about |
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Definition
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Term
| Flesh colored dome lesion with central umbilication |
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Definition
Molluscum contagiosum: Pox virus
Will go away in about 1 year.
Vaccinia- cowpox ("milkmaid's blisters") |
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