parasympathetic nerve, the wanderer

stimulated by distension/irritionation of the pharynx, stomach, gall bladder, peritoneum, duodeum, uterus, kidney

block dopamine receptors in the CRTZ and vomiting center also block histamine

causes hypertension

acepromazine chlorpromazine prochlorperazine (sedation may lower siezure threshold)

released by basophils and mast cells during inlfammation or an allergic reaction

H1- skin respi. tract vasc. tissue smooth muscle brain

H2- stomach parietal cells (release of HCL into the GI tract) others

used for motion sickness

decreases imput from vestibular apparatus to the vomiting center by blocking H receptors in the CRTZ

diphenhydramine

dimenhydrinate

meclizine

systemic antacids

competitive inhibitionof h2 receptors block secretion of HCL

cimetidine

ranitidine

famotidine

stagger doses with other drugs that rely on acidity

metabolized by the liver

iv im sq po