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Lymphatic System
Lymphatic System
33
Anatomy
Undergraduate 3
05/25/2011

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Cards

Term
What are the two types of lymph tissue?
Definition
Diffuse and Dense
Term
What are the structural units of lymphoid tissues?
Definition
lymph nodules
Term
What is the difference between dense and diffuse lymphatic tissue?
Definition

Dense has capsule around nodules

Diffuse is non-capsulated

Term
What is the role of the lymphatic system?
Definition

Drain interstitial fluid

Immune defense

Transport lipid/lipid-solubles from GI tract to vascular sys

Term
Where is lymph filtered?
Definition
Lymphatic nodes
Term
A lymphoid organ is comprised of what kind of lymphatic tissue?
Definition
Dense LT
Term
What are the types of diffuse LT?
Definition

MALT-Mucus

GALT-Gut

BALT-Bronchus

 

Term
True/False: Lymph nodes are lymphoid organs
Definition
True: they are capsulated
Term
What types of cells predominate in the cortex of a lymph node?
Definition
B- Cell
Term
What types of cells predominate in para-cortex of lymph nodes?
Definition
Macrophage and T cell
Term
What types of cells predominate in  the medulla of a lymph node?
Definition
T-cell and macrophages
Term
How does an activated lymph node differ from that of a non-activated one?
Definition
activated lymph node has Germinal Center (zone of proliferation)
Term
What is a primary nodule?
Definition
A non-activated lymph node (no germinal center)
Term
What is a secondary nodule?
Definition

an activated lymph nodule

Has Germinal center

Term
Describe the path of lymph through a lymph node
Definition

Afferent lymph vessel->Subcapsular sinus->

trabecular sinus-> Medullary sinus->Efferent lymph vessel

Term
Describe maturation of T cell in lymph nodes
Definition
  • APC's are activated by cytokenes
  • APC's migrate from Mucosal membranes to lymphnodes
  • Immature T cells produced in bone marrow migrate to nodes
  • T cell scan peptide carried by APC, and will proliferate, mature if recognized
Term
Describe how B cells fight against pathogens
Definition
Divide into memory or plasma cells that produce antibodies
Term
How do antibodies destroy pathogen molecules?
Definition
  1. Neutralization Cover toxic active site
  2. Agglutination forming clumps of pathogens
  3. Precipitation Clumping of anitigen molecules
  4. Activating complement proteins which create pores in cell-->lysis
Term
Which ebryonic germ layer does thymus arise from?
Definition
endoderm
Term
The lobule is a structural unit of which lymphatic organ?
Definition
Thymus
Term
Describe the cortex of a thymus lobule
Definition

No lymph nodule or plasma cells

ONLY reticular and macrophage cells

Term
Which types of ERC found in cortex?
Definition
ERC 1-3
Term
What is the role of ERC I?
Definition
surround blood vessels
Term
what is the role of ERC II?
Definition
separate T-cell to T-cell transmission
Term
What is the role of ERC II?
Definition
separates cortex from medulla (cortical side)
Term
What separates the cortex from medulla of the thymus?
Definition

ERC III and ERC IV

 

Term
What is the role of ERC V?
Definition

negative elimination

Surrounds T cells and removes those with wrong antibody

Term
What is the role of ERC VI?
Definition
These are dead ERC's or dying ERC's
Term
What is the Hassell's Corpsucle?
Definition
Aggregation of dead ERC's in the medulla
Term
What are regulatory T-cells
Definition
Complete negative selection of cells that get rid of faulty T-cells that have escaped thymic censorship
Term
Define white pulp
Definition

The lymphoid tissue of the spleen that surroudns vessels holding T cell

or lymphatic nodules that house B cells

 

Term
Red pulp define
Definition
Regions of the spleen taht house the chords of cells, reticular, plasma, macrophage and blood sinus
Term
Describe the path of blood through the spleen
Definition
  • Blood enters through central artery
  • Central artery surroudned by T cell LT (PALS)
  • Central artery branches and forms into sinusoids near nodule periphery
  • Macrophages located just outside lymph node destroy old RBC
  • Healthy RBC's collect in another sinusoid and return back to venous
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