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Lecture 13 & 14
Genetics of Cancer
9
Veterinary Medicine
Not Applicable
02/26/2017

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Cards

Term
What are the 3 main 'questions' to answer when diagnosing cancer?
Definition
What is it
Where is it
How bad is it (staging)
Term
Which has a better prognosis, B cell or T cell lymphosarcoma?
Definition
B cell
Term
Characteristics of benign tumours
Definition
-localized
-non invasive
-often encapsulated
Term
What are some immnotherapeutic agents used to treat non-hodgkins lymphoma? How does this work?
Definition
AT-004 & AT-005

monoclonal antibodies which will target B cells or T cells which express CD20 (95% of malignant cells express this)
Term
What are some agents used to treat cancer using gene therapy?
Definition
tyrosinase
s100
gp100
Melan-A
Term
What are the checkpoints in place that normally regulate cell proliferation?
Definition
-if genome is damaged, won't enter S phase or DNA replication stops in 'S' until it is repaired

-if replication isn't completed, during G2, cell arrests

-cell arrested in M if chromatids don't attach to spindle properly
Term
What is 'kit' and what does it do?
Definition
kit is an oncogene which is upregulated by protein kinase in the plasma membrane, stimulating accelerated proliferation
Term
What is a mast cell tumour? How might you treat this?
Definition
constitutive phosphorylation of KIT due to duplications in exons 11 & 12

can use tyrosine kinase inhibitors
Term
What is the importance of p53 in cancer?
Definition
this gene is abnormal in >50 of human cancers, and many canine and feline cancers as well
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