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| American Association for Laboratory Animal Science |
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| Assistant Laboratory Animal Technician |
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| Laboratory Animal Technician |
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| Laboratory Animal Technologist |
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| American College of Laboratory Animal Medicine |
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| Institutional Animal Care and Use Committee |
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| National Institutes of Health |
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| Food and Drug Administration |
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| United States Department of Agriculture |
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| Institute for Laboratory Animal Research |
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| American Society for Laboratory Animal Practitioners |
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| National Association for Biomedical Research |
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| National Research Council |
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| Certified Manager Animal Resources |
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| Foundation for Biomedical Research |
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| American Veterinary Medical Association |
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| Laboratory animal medicine |
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Definition
| the specialty field within veterinary medicine that is concerned with the diagnostics, treatment, and prevention of diseases in animals used in research, testing, and teaching. |
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| Laboratory animal veterinarian jobs: |
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Definition
| Production of quality animals, provision of adequate veterinary care, management of animal care and use facilities, education of individuals who care for and use laboratory animals, assisting biomedical scientists in the selection of and humane use of animals, and assurance of compliance with all regulations and policies that affect research animals |
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| Area of science that investigates the biological process and cause of disease |
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| Replace animals with other models whenever possible |
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| Reduce the number of animals |
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| Refine our techniques in order to reduce stress |
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| Regulates the use of many vertebrates, requires research facilities to register with the USDA, IACUC, APHIS |
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| Administers, inspects, and enforces the AWA in USDA registered facilites |
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| Requires ALL new drug, medical devices, chemical compounds be tested on animals before being tested on humans |
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| In charge of the protocols to treat animals covered by the USDA. Makes all decisions of how animals will be handled. |
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| Require institutions to adhere to USDA AWA regulations and The Guide. Simplifies the AWA, covers more species than those protected by the AWA, is considered an international standard. |
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Definition
| The Guide for the Care and Use of Laboratory Animals |
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| USDA License A facilities |
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Definition
| Dedicated to the production of animals |
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| USDA License B facilities |
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Definition
| Committed to other purposes but may sell to research institutions |
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Term
| Laboratory Animal Medicine |
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Definition
| Specialty area of veterinary medicine that focuses on the diagnosis, treatment, and prevention of diseased in animals used for teaching, testing, and research. |
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| Laboratory Animal Science |
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Definition
| Scientific, technical, and medical information and techniques applying to lab animal care and use (only recognized in the 1950s) |
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Definition
| NIH, NSF, local government, private organizations |
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| IACUC Committee Composition |
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Definition
| 1 DVM, 1 outside representative, and 1 more person. NIH requires 5 members. |
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| Research Team Composition |
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Definition
| Laboratory Veterinarian, Primary Investigator, Laboratory Technician |
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| First law to protect non-farm animals |
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| Species covered by the AWA |
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Definition
| Cats, Dogs, Non-human primates, Guinea pigs, Rabbits, Marine Animals, Birds, wild-caught animals, any other warm-blooded animal in research, testing, exhibition, and pet services (alive or dead) |
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| Species not covered by the AWA |
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Definition
| Reptiles, Fish, Amphibians, Rats, Mice, large animals not used for research |
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| Veterinary Medical Officer, must visit annually, but may come as frequently as they like |
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| APHIS points of inspection |
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| Standards of care- food, water and sanitation, lighting, ventilation, animal shelter, separation of species, adequate veterinary care |
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| Must be kept for 1 year after an animal's death or adoption (AWA), 3 years (NIH), or 5 years (FDA) |
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| Enforced development of IACUCs, training for lab animal technicians, and set standards for exercise and well-being of dogs and non-human primates |
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| Office of Laboratory Animal Welfare (part of NIH) |
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| Reports made by the PI to justify animal research and use to the IACUC |
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| Good Laboratory Practice Regulations, adopted and enforced by the FDA and EPA |
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Definition
| Must be in a separate room, in a dry, cool, clean area, off of floor and away from the wall, stored in a lined canister with a lid, pest control policies, food may be frozen for freshness |
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Definition
Commercial- up to 6 months
Vitamin C- 90 days |
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Definition
| Must be dry and clean. NO MOLD. |
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| __% of lab animal diets should be in pelleted form |
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Definition
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| 2 reasons why it is important to be quiet in labs |
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Definition
| The noise stresses the animals (BITE) and if it is quiet, we can hear animal down |
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| Can you participate in lab without a lab coat? |
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Definition
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| If a bite breaks the skin |
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Definition
| 1. Put the animal down 2. Wash your hands 3. If needed, use a Band-Aid 4. Seek medical attention if necessary |
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Definition
| 1. Say "{species} down" 2. Everyone freezes |
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| 5 ways to be signed off on a task |
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Definition
| 1. In lab 2. During the TA-run Animal Handling Clinics 3. With a TA during tutoring time 4. With the primary instructor during tutoring time 5. In future labs |
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| What must you do before grabbing the animals? |
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Definition
| Wash hands and clear cage of objects |
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Term
| How do you get a mouse out of the cage? |
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Definition
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| What fingers should you scruff a mouse with? |
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Definition
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| Can mouse restraint be with both hands? |
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Definition
| The distance between the urinary opening and the anus |
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| Who has a greater anogenital distance? |
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Definition
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| Clear base, "v" top for feeding and watering |
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| Quality animal care = quality research |
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Definition
| Used to monitor colony health, exposed to same conditions as the research animals, if disease found- reflects disease in colony |
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| Benefits of suspended cages |
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Definition
| Automatic watering, HEPA filtration, reduced animal maintenance, mobile |
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Definition
| Collect urine and feces, not permanent, no bedding |
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Definition
| Cardboard, must include an extra day's worth of food & water, short-term |
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Definition
| May be a shoebox with a running wheel, may be a large enclosure for animals to interact in (gang/colony), may be a run for a dog or a pen |
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Definition
| Designed to restrain the animal. Non-human primates. |
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Definition
| Shoebox with filter on top to prevent outside pollutants and diseases from coming inside. Must be worked with under a laminar flow hood (for immunocompromised animals) |
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| Which two species can be restrained one-handed? |
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Definition
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| Number 1 rule of hamster restraint |
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Definition
| Make sure the hamster is aware of you |
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| How to we get a gerbil out of the cage? |
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Definition
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| Which animal is prone to seizures? |
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Definition
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| How do you sex a mouse, hamster, or gerbil? |
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Definition
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| Where are SQ injections given? |
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Definition
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| What species can receive IM injections? |
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Definition
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| Where is the retro-orbital sinus located? |
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Definition
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| Which species cannot be injected IM? |
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Definition
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Term
| Where else can we draw blood from rats? |
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Definition
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| Where else can we draw blood from mice? |
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Definition
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| How do we restrain a rat? |
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Definition
| Whole hand scruff and hold tail with other hand |
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| How do we restrain a gerbil? |
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Definition
| Scruff and hold tail with other hand |
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| How do we restrain a hamster? |
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Definition
| Whole hand scruff all the way down the back |
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| How do we restrain a mouse? |
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Definition
| With one hand scruff and hold tail |
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| Which species is prone to seizures, jumping, and tail degloving? |
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Definition
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| Which species will make lots of noise to be let go? |
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Definition
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| Which species tend to bite? |
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| Bald patch on ventral thorax |
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