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LA toxicology
Toxins - pesticides, metals and plants
11
Veterinary Medicine
Undergraduate 3
05/21/2012

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
Paraquat
Definition
-a herbicide
-skin and MM ulceration and necrosis
-irritation and corrosion of GIT w. D and ab. pain
-hyperexcitability
-bruxism
-pul. oedema, death
Term
Organophosphates
Definition
-muscarinic and nicotinic clinical signs w. death in hrs - days
NB: may be delayed signs in ruminants but still generally results in death
Term
Aluminium
Definition
Ingestion of soil containing insoluble aluminium salts
-clin. signs not ve specific:
-dec. food intake, wt loss, hypophosphataemia, haemolysis (w. pale MM), weakness, seizures
Term
Copper
Definition
Copper sulphate = fungicide
Over-supplementation of feed is possible
-acute poisoning - facial oedema, jaundice, epistaxis, anaemia, anorexia, seizures
-death in hours
Term
Ammonium nitrate
Definition
Ingestion from over enriched food / fertiliser - death can be rapid and w/o clinical signs
-hyperexcitability, bruxism, trembling, coma
Term
Plant toxins
Definition
-Alflatoxin (produced by Aspergillus flavus)
-Yew
-Ragwort
-Rhododendron
-Deadly nightshade
Term
Aflatoxin
Definition
A mycotoxin produced by Aspergillus flavus - grows esp. when warm and humid, grows on oats, barley, soya
-hepatotoxic, carcinogenic, teratogenic, immunosuppressant
Term
Yew
Definition
cardiotoxic - inhibits Na+/Ca2+ channels and so prevent normal excitability needed for normal cardiac rhythms
-lethargy, V+D, ptyalism, mydriasis, trembling, ataxia
-hypotension, bradycardia, resp. depression
Term
Ragwort
Definition
Hepatotoxic - generally fatal
-anorexia, wt loss, constipation, jaundice, blindness, ataxia, trembling, weakness
-dermal photosensitivity in horses
Term
Rhododendron spp.
Definition
Cardiac toxins
-V+D, ptyalism, ab. pain, weakness
-hypotension, dysponea, arrhythmias
Term
Deadly nightshade
Definition
-produce atropine! i.e. parasympatholytic
-tachhycardia, mydriasis, visual disturbances
-disorientation, ataxia at higher conc.
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