Term
| What 5 things is corneal clarity based on? |
|
Definition
1) presence of highly organized collagen fibrils,
2) proper proteoglycan chemistry
3) state of deturgesence
4) absence of blood vessels
5) absence of pigmentatation |
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|
Term
| What causes loss of corneal clarity? |
|
Definition
loss of deturgesence
influx of water
vascularization |
|
|
Term
What is corneal vascularization an indicator of?
In what animals does this occur without pathogenic association? |
|
Definition
disease/abnormality
manatee and some lab mice |
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|
Term
| What does extensive epithelial corneal repair involve? |
|
Definition
|
|
Term
| How is stromal corneal repair carried out? |
|
Definition
re-establish normal cell population
re-establish normal ECM |
|
|
Term
| Can corneal endothelium be repaired? |
|
Definition
poor in most species
adjacent cells spread out to areas of cell loss, resulting in decompensation |
|
|
Term
| What does unsuccessful corneal repair lead to? |
|
Definition
loss of fiber organization
loss of transparency |
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|
Term
|
Definition
| the corneoscleral interface |
|
|
Term
| What does the limbus contain? |
|
Definition
vasculature
can contain pigment |
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|
Term
| T/F: limbal epithelium is thicker than corneal epithelium. |
|
Definition
|
|
Term
| How does the limbal epithelium contribute to the corneal epithelium? |
|
Definition
| the limbal epithelium is a site of regeneration for major loss of corneal epithelium |
|
|
Term
| Where do limbal vessels originate from? |
|
Definition
| branches of the anterior ciliary arteries |
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|
Term
| What is a common surgical site of the eye? |
|
Definition
|
|
Term
| How much of the fibrous tunic does the sclera make up? |
|
Definition
|
|
Term
| What is the sclera similar to in composition? |
|
Definition
|
|
Term
| What is the sclera made up of? |
|
Definition
| dense irregular connective tissue |
|
|
Term
| is the sclera vascularized? |
|
Definition
|
|
Term
| Is the sclera inntervated? |
|
Definition
|
|
Term
| Does the sclera have an epithelium? |
|
Definition
|
|
Term
| What makes up scleral ECM? |
|
Definition
irregular fibrillar sze (type 1)
dermatan sulfate ladened PGs |
|
|
Term
| What are the regions of the sclera? |
|
Definition
lamina fusca (innermost)
sclera proper
episclera |
|
|
Term
| What is the sclera proper composed of? |
|
Definition
| dense irregular connective tissue with variably sized collagen fibrils |
|
|
Term
| What is the episclera composed of and where is it located? |
|
Definition
loose connective tissue
blends posteriorly with serosal lining (tenons capsule)
anteriorly with bulbar conjunctive |
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|
Term
What do non-mammalian sclera have?
What does it extend to? |
|
Definition
cartilaginous cup
extends to limbus in amphibia and fish
extends to ring of ossicles in reptiles, birds, some fish |
|
|
Term
| What is the role of ossicles? |
|
Definition
| provide additional ocular rigidity to enhance refraction |
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