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Insecticides
Drugs and definitions
13
Veterinary Medicine
Undergraduate 3
05/14/2012

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Term
Organophosphates
Definition
insecticides which irreversibly inhibit acetylcholinesterase, so ACh accumlates - results in spastic paralysis
-low TI - now banned
Term
Carbamates
Definition
insecticides which reversibly inhibit acetylcholinesterase, so ACh accumlates - results in spastic paralysis
Term
Imidaocloprid
Definition
Insecticides which inhibit AChR in insect CNS, resulting in flaccid paralysis and death
Term
Pyrethoids
Definition
Insecticides which cause prolonged opening of voltage-dependent Na+ channels and so prolonged depolarised after potential - hypersensitive so whole system locks up
e.g. permethrin, cypermethrin
Term
Permethrin
Definition
A pyrethoid insecticides - cause prolonged opening of voltage-dependent Na+ channels and so prolonged depolarised after potential - hypersensitive so whole system locks up
Term
Amidines
Definition
Insecticide which blocks octopamin R (the vertebrae equivalent of noradrenaline) - results in CNS hypersensitivity
-contraindicated in horses
e.g. amitraz
Term
Amitraz
Definition
An amidine insecticide which blocks octopamin R (the vertebrae equivalent of noradrenaline) - results in CNS hypersensitivity
-contraindicated in horses
Term
Fibronil
Definition
An insecticide - GABA-R antagonists i.e. inhibits neuronal inhibition and hyperpolarises cell membrane - hyperexcitation in CNS and PNS resulting in convulsions and death
NB: fibronil = frontline
Term
Avermectins
Definition
Macrocyclic lactone anthelmintic,can be used an insecticide - GABA-A-R agonists- inhibit neurotransmission.
Term
Juvenile Hormone Analogues
Definition
A class of insect growth regulator / insecticide - analogues cause development of abnormal pupae ad prevent emergence of viable adults (normal hormones prevent metamorphosis until larve is fully grown)
e.g. Methoprene
Term
Methoprene
Definition
A juvenile hormone analogue insecticide
- cause development of abnormal pupae ad prevent emergence of viable adults (normal hormones prevent metamorphosis until larve is fully grown)
Term
Chitin synthesis inhibitors
Definition
Class of insect growth regulator / insecticide - drugs inhibit the enzymes which synthesise chitin (forms support elements in exoskeleton) - affects developing offspring rather than adults
Benzyl ureas e.g. lufenuron (Program)
Term
Lufenuron
Definition
a chitin synthesis inhibitor insecticide - drugs inhibit the enzymes which synthesise chitin (forms support elements in exoskeleton) - affects developing offspring rather than adults
NB: = Program
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