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immune2
immune2
54
Anatomy
Undergraduate 4
02/20/2012

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Term
antibody-mediated defense
Definition
defends against FREE viruses and bacteria in bodily fluids
Term
cell-mediated defense
Definition
defends against abnormal cells-cancer transformed cells, viral cells, foreign cells
Term
what are the 3 stages of both defense types
Definition
1.antigen encounter and recognition by lymphocytes
2.lymphocyte activation and clonal expansion
3.attack
Term
what both humoral and cell mediated responses require?
Definition
activation of helper T-cells
Term
type of immunity when antibodies are transferred to from a person to another person
Definition
passive immunity
Term
natural acquired passive immunity
Definition
transfer of antibodies in breastmilks or placenta
Term
induced passive immunity
Definition
administration of anitboooodies to combat infection, like a vaccine
Term
type of immunity when antibodies were produced in response to antigens
Definition
active immunity
Term
type of immunity when antibodies that develop in response to antigens
Definition
active immunity
Term
induced active immunity
Definition
develops after administration of antigen to prevent disease.
Term
type of immunity the develops after exposure to antigens in environment
Definition
naturally acquired ACTIVE immunity
Term
4 properties of acquires (specific_ immunity) SVMT
Definition
specificity, versatility, memory, tolerance.
Term
what are the 2 types of lymphocytes?
Definition
T and B
Term
T lymphocytes:where do they mature, and what are the three types
Definition
cytoxic T cells, helper T cells, suppressor T cells
Term
B lymphocytes-where do they mature, and what cells do they give rise to
Definition
Bone marrow, antibody secreting plasma cells
Term
cytotoxic T cells
1.effectors for cells mediated or humoral response?
2.what type of cells do they attack?
3. type of receptor?
Definition
1. cell mediated
2.infected/transformed cells
3.CD8
Term
helper T cells
1.regulatory function in cellbody mediated, humoral, or both?
2.type of receptor
Definition
1.both
2. CD4(t4) receptor
Term
suppressor T cells-function?
Definition
inhibit B and t Cells
Term
B cells-carry out cell mediated or humoral immunity
Definition
humoral aka antibody mediated
Term
T cell receptors
1.how many chained protein
2.what does this receptor need on the antigen to bind to it
Definition
1.2 chains
2.the antigen must be complexed to an MHC "self" protein
Term
B cell receptors
1. what is attached to the cell
2.what is Ig a copy of that the cell can produce?
Definition
1.Immunoglobulin-Ig
2.Ig is a copy of an antibody
Term
what is immunocompetence
Definition
maturation of immune cells to do WORK son!
Term
when do lymphocytes acquire the ability to "recognize" antigens? how is this process determined. ALso, what two traits does this give to the immune system
Definition
when lymphocytes acquire receptors specific to THAT antigen.

it is determined by genetics

it makes the immune system versatile, and specific
Term
another name for antigenic determinants
Definition
epitopes
Term
what are antigenic determinants/epitopes
Definition
sites where antibodies bind to on the antigen..and "active site" if you will...
Term
what type of lymphocytes secrete Antibodies
Definition
B lymphocytes
Term
on antibodies, what region is involved in the effector mechanism
Definition
the constant ends (bottom of the Y)
Term
on antiboooooodies, which end binds antigens
Definition
variable regions
Term
the typical antibody, it can cross placentas, Ab (80%)
Definition
IgG
Term
antibody involved in alergic responses
Definition
IgE
Term
antibody that we don't have a fucking clue about
Definition
IgD
Term
antibody that is 1st to appear after Ag
Definition
IgM
Term
antibody in saliva, tears,l colostrum, breasteseses milkss
Definition
IgA
Term
what do histocompatibility proteins identify
Definition
"self"
Term
MHC class 1
1. on what cells
2.recognized by what immune cell
2. what type of receptor does that immune cell have
Definition
1. on all cells
2.cytotoxic T cells
3. CD8 receptors
Term
MHC class II
1. on what cells
2. what are those^ cells called?
3. the other 1 cell that recognizes it
Definition
1. macrophages, B cells, dendritic cells
2. APCs:Antigen presenting cells
3. Helper T cells (CD4 Receptors)
Term
infected cells present their antigen to which cells?
Definition
cyto-toxic T cells
Term
APCs present their antigen to whom?
Definition
helper Tcells
Term
3 events required for activating Tcells
Definition
1.presentation of antigen bound to class II MHC protein to the APC
2.costimulation, binding of non antigenic proteins on APC and helper T-cell
3.APC secretes cytokines that help helper tcell
Term
two cytokines released by helper Tcell after antigen presentation
Definition
1.IL-1
2.TNF
Term
IL-1 function
Definition
promotes inflammation, fever, and sepsis
Term
TNF function
Definition
-it stands for "tumor necrosis factor"
-promotes apoptosis
Term
write out the antibody mediated immune response mechanism
Definition
just do it
Term
for humoral response are the effector mechanisms specific or non specific.
Definition
non specific-like the MAC mech
Term
what cells produce a more rapid and amplified response if the same antigen is encountered again?
Definition
memory cells
Term
giardia is attacked by which response system?
Definition
cell mediated, since it is a virus that attacks other cells that have become infected.
Term
what cells carry out the cell mediated response mainly? which receptor does this cell have?
Definition
cytoxic Tcells, CD8+
Term
what is the ONLY thing that cytoxic T cells respond to
Definition
antibooooodies on OUR OWN infected cells. aka antigenic determinant
Term
infected cells present the antigenic determinant on which MHC class receptor?
Definition
MHC CLASS 1. fucking remember it.
Term
a macrophage well present an antigen to Helper T cells with which MHC class protein
Definition
MHC class 2
Term
once a macrophage activates a helper T cell, what does the T(h) cell do to the cytotoxic t cell
Definition
it activates the cytoxic t Cell with cytokines (like IL-2) for clonal expansion
Term
write the cell mediated response mechanism
Definition
don't fucking bitch JUST DO IT
Term
what protein is used by cytotoxic T cells to destroy other cells
Definition
perforin
Term
for the cell mediated response, what cells "roam" the tissues and destroy any mutant cells that display a processed antigen
Definition
cytoxic tCells
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