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Immune System
Hamster!!
28
Anatomy
Undergraduate 4
12/14/2010

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Cards

Term
What is the function of the Immune System?
Definition
Protection
Term
Define antigen
Definition
Proteins on the surfaces of bacteria/viruses that are recognized as foreign
Term
Which cell types attack antigens nonspecifically?
Definition
macrophages, neutrophils through phagocytosis
Term
Which cell types attack antigens specifically?
Definition
lymphocytes (B and T)
Term
Granulocytes
Definition
neutrophil, eosinophil, basophil
Term
agranulocytes
Definition
monocyte, lymphocyte
Term
neutrophil function
Definition
phagocytosis and destruction of damaged cells, bacteria, etc.
Term
eosinophil
Definition
exocytosis of enzymes to destroy parasites, secreted during allergic reactions
Term
basophil
Definition
anticoagluant, promotes leakiness of the vessels
Term
monocyte
Definition
form macrophages for phagocytosis of antigens
Term
lymphocytes
Definition
Immune response against antigens
Term
Where do lymphocytes get educated to recognize self vs. nonself?
Definition

B cells-bone marrow

T cells-thymus

Term
Where does lymphocyte development take place?
Definition
bone marrow
Term
immunocompetent
Definition
The B and T lymphocytes have learned which antigens they each respond to and have surface receptors able to recognize one unique type of antigen
Term
Where are educated lymphocytes found?
Definition
lymphatic organs and connective tissues throughout the body
Term
What kinds of antigens stimulate T cells?
Definition

intracellular antigens (viruses)

Cell Mediated Immunity

Term
What kinds of antigens stimulate B cells?
Definition

extracellular antigens (bacteria)

Antibody Mediated Immunity(AMI)

Term
Helper T cell activation
Definition

1)A macrophage ingests an antigen, degrades it and presents a portion on its surface

2)The inactive helper T cell binds to it

3)The macrophage secretes chemicals that activate the helper cell

Term
B cell activation
Definition

1)B cell binds, ingests, degrades and presents another copy of the antigen

2)Activated helper cell specific for that same antigen recognizes the presented antigen

3)Helper cell secretes chemicals that activate the B cell

4)B cell divides

Term
B cells divide into what?
Definition

1) Plasma cells-secrete antibodies for current infection(effector cells)

2) Memory cells for next exposure

Term
Antibody Mediated Immunity(AMI)
Definition

1)Plasma cells secrete antibodies that bind to additional copies of the antigen(bacteria)

2)The anti-body coated antigen is more attractive to macrophages that will engulf and destroy them

Term
T cell(CD8) activation
Definition

1)A macrophage presents the antigen

2)CD8 T cell binds to it

3)An activated helper cell specific for the same antigen recognizes the macrophage/CD8 cell complex

4)It secretes chemicals to activate the CD8 cell

5)The CD8 cell divides

Term
T cell(CD8) divides into what?
Definition

1) Memory cells

2) Active CD8 cells that kill other infected cells

Term
T Lymphocytes do what?
Definition
Activated T cells(CD8) cells secrete proteins that lyse the cell's membrane and signals the cells to die, which they do
Term
Memory cells
Definition
1)Formed from activated B and T cells that do not respond during a current infection, but can respond quickly if the same antigen ever enters the body
Term
Vaccinations
Definition

1)Intentional exposure to weakened or inactive versions of common disease causing organisms

2)Stimulates the immune system to respond and to form memory cells

3)usually receive multiple

Term
Autoimmunity
Definition

The immune system recognizes its own tissue as foreign

ex. diabetes mellitus and lupus 

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