Term
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Definition
•Autoimmune disorders
•Immunodeficiency disease
•Allergies |
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Term
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Definition
| malfunction of immune system that recognizes and ignores “normal” antigens |
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Term
| in Autoimmune Disorders Activated B cells make |
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Definition
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Term
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Definition
| antibodies made against the body’s own antigens/cells |
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Term
| 3 ex of autominmmune disorders in which B cell makes autoanitbodies |
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Definition
Thyroiditis
•Rheumatoid arthritis
•Insulin-dependent diabetes mellitus (IDDM) |
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Term
| Immunodeficiency Diseases can Result from |
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Definition
embryological development of lymphoid tissues
HIV/AIDS
Immunosuppressive drugs or radiation treatments |
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Term
| Problems with embryological development of lymphoid tissues can result in |
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Definition
| severe combined immunodeficiency disease (SCID) |
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Term
| Viral infections such as HIV (human immunodeficiency virus Selectively infect _______ &Can result in ______ |
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Definition
| helper T (CD4) cells, AIDS |
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Term
| Immunosuppressive drugs or radiation treatments Can lead to |
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Definition
| complete immunological failure |
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Term
| Example of a immunosuppressive drug that is given after an organ transplant |
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Definition
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Term
| cyclosporin a (an immunosuppressive drug) does |
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Definition
| suppresses helper t cells |
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Term
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Definition
| Inappropriate or excessive immune responses to antigens |
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Term
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Definition
| Antigens that trigger allergic reactions |
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Term
| Four Categories of Allergic Reactions |
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Definition
1. Immediate hypersensitivity Type I
2. Cytotoxic reactions Type II
3. Immune complex disorders Type III
4. Delayed hypersensitivity Type IV |
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Term
| Type I Allergic Reactions |
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Definition
Immediate hypersensitivity
(aka you are immedialty experience symptoms e.g. rash, fever) |
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Term
| Type II Allergic Reactions |
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Definition
Cytotoxic reactions
(you t cell are responding) |
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Term
| Type III Allergic Reactions |
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Definition
Immune complex disorders
(aka antigen-antibody complex formed) |
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Term
| Type IV Allergic Reactions |
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Definition
Delayed hypersensitivity
(opposite of type 1 not easily triggered) |
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Term
| Type I Allergic Reactions:Immediate hypersensitivity |
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Definition
| A rapid and severe response to the presence of an antigen |
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Term
| Most commonly recognized type of allergy is |
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Definition
| type 1: immediate hypersenstivity |
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Term
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Definition
| allergic rhinitis (environmental allergies) |
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Term
Type I Allergy Sensitization leads to
(aka the person has already encountered the antigen ONCE) |
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Definition
| Production of large quantities of IgE antibodies distributed throughout the body |
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Term
| Type I Allergy:Second exposure leads to |
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Definition
| Massive inflammation of affected tissues |
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Term
Type I Allergy
•Severity of reaction depends on: |
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Definition
•Individual sensitivity
•Locations involved |
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Term
| Allergens (antigens that trigger reaction) in bloodstream may cause |
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Definition
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Term
| Anaphylaxis Can be ______ and usually affects cells _______ |
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Definition
| fatal,throughout the body |
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Term
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Definition
Changes capillary permeability
Smooth muscles of respiratory system contract
Peripheral vasodilatation |
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Term
Changes capillary permeability
•Produces |
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Definition
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Term
| Smooth muscles of respiratory system contract cause |
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Definition
| breathing to be more difficult |
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Term
Peripheral vasodilatation
•Can cause |
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Definition
| circulatory collapse (anaphylactic shock |
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Term
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Definition
Drugs that block histamine released by mast cells
•Can relieve mild symptoms of immediate hypersensitivity
•Benadryl |
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Term
| in periods of stress what is Secreted to limit immune response |
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Definition
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Term
| Long-term secretion (chronic stress) has what 2 effects on body? |
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Definition
Inhibits immune response
•Lowers resistance to disease |
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Term
| Functions of Glucocorticoids |
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Definition
Decrease of the inflammatory response
•Reduce: # & activity of phagocytes
•Inhibition of interleukin secretion |
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Term
| Immune System Diminishes with |
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Definition
Age
=
Increasing vulnerability to infections and cancer |
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Term
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Definition
1. Thymic hormone production is greatly reduced
2. T cells become less responsive to antigens
3. Fewer cytotoxic T cells responding to infections
4. Decreased numbers of helper T cells
*thymus involutes |
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Term
| Nervous and Endocrine Systems Interact with _______ in order to |
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Definition
| Adjust sensitivity of immune response |
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