Term
| Graft from same individual |
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Definition
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Term
| Graft where donor & recipient are genetically identical |
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Definition
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Term
| Graft from same species, different genome |
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Definition
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Term
| Graft from different species |
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Definition
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Term
| 3 triggers of allograft rejection |
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Definition
Blood antigen mismatches
Histocompatibility (MHC) mismatches
Foreign antigens presented by MHC |
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Term
| 4 stages of graft rejection & their primary effector |
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Definition
1. Hyperacute - hours - pre existing Abs
2. Accelerated - days - memory cells
3. Acute - weeks - T cells
4. Chronic - months- Abs |
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Term
| Why do skin allografts take so long to be rejected |
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Definition
| bc blood supply isn't directly connected to tissue at time of surgery |
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Term
| Why is dog liver graft rejection slow |
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Definition
| canine hepatocytes produce lots of IDO which catabolizes tryptophan, preventing Th1 cells from mounting an immune response |
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Term
| 3 steps for transplanting allogeneic bone marrow |
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Definition
1. Kill host bone marrow
2. IV infusion of donor bone marrow
3. Prophylactic antibiotics for up to 200 days |
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Term
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Definition
| happens if the donor immune cells recognize the host as foreign, resulting from bone marrow transplant |
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Term
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Definition
concordant = similar species
discordant = very different species |
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Term
| Why dont sperm get rejected |
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Definition
| they have immunosuppresive seminal plasma, so they are not immunogenic |
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Term
| If a recipient had a graft, rejected it, nd then the subsequent graft is rejected, what is this called? What causes it? |
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Definition
accelerated rejection
T cells |
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Term
| Chronic rejection of grafts (months later) is often due to... |
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Definition
| antibodies / b cells (b cells are hard to tolerize) |
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