Shared Flashcard Set

Details

Immune 13 & 14 & 15
Viruses
21
Veterinary Medicine
Not Applicable
04/11/2017

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
What is a virome?
Definition
non-pathogenic virus
Term
What is the difference between Type I vs Type II IFNs
Definition
Type I - innate antiviral response induced by PAMPs

Type II - associated with Th1 adaptive immune response
Term
Retroviral double stranded RNA is recognized by what TLR?
Definition
TLR 3
Term
Single stranded RNA is recognized by what TLR?
Definition
TLR7/8
Term
Viral DNA is recognized by what TLR?
Definition
9
Term
What cells produce the most Type I IFN?
Definition
plasmacytoid DCs
Term
The key effector cell in antiviral immune responses
Definition
CD8 cytotoxic T cells
Term
Which is associated with a sudden change, antigenic drift or shift?
Definition
shift
Term
Which type of vaccine involves replication inside cells, attenuated or inactivated vaccines?
Definition
attenuated (live)
Term
What do adjuvants do?
Definition
enhances the immune response to a vaccine, or influences the type of response that is induced
Term
4 types of vaccines
Definition
Recombinant proteins
Attenuation
Live recombinant
Polynucleotide (functional DNA)
Term
Seroconverstion
Definition
when pathogen-specific antibodies can be detected in serum
Term
How do vaccines complicate serology
Definition
Can make it difficult to tell whether the animal seroconverted due to disease, or due to vaccine exposure.

-get around this by using vaccines that omits an antigen, so if you see antiobodies for that antigen you know it's bc the animal was diseased
Term
3 reasons vaccines need to be readminstered
Definition
1. competing with passive immunity;
2. to boost immunity;
3. to account for antigenic variation of pathogens over time)
Term
Duration of immunity & when to give boosters
Definition
Distemper is <1 year
Rabies > 3 years
All others > 7 years
Term
Ring vs predictive vaccination during an outbreak
Definition
Ring - create a barrier of vaccinated animals around an outbreak

Predictive - vaccinate the ones that are most likely to get sick (shipped animals, young etc)
Term
Why vaccines fail
Definition
-incorrect administration
-failure to respond
-
Term
Animal size & adverse effect of vaccines
Definition
more likely to occur in small dogs. but it is NOT recommended to reduce dosage for small dogs, not enough research behind how much is reqd for effective protection
Term
Vaccine induced anaphylactic shock - treatment
Definition
epinephrine
Term
Why give killed vaccines to weims
Definition
prone to osteodystrophy as a reaction to live distemper vaccines
Term
True or False

Ring vaccination and predictive vaccination are examples of prophylactic strategies
Definition
false
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