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Hormonal, endocrine, reproductive drugs
Pharmacology
110
Veterinary Medicine
Not Applicable
06/28/2020

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Cards

Term
links nervous and endocrine systems
Definition
hypothalamus
Term
6 endocrine glands
Definition
pituitary

adrenal

thyroid

ovaries/ testes

pancreas

kidneys
Term
hypothalamus is influenced by what triggers?
Definition
odors

sounds

sights

stress

temperature

photoperiod

hormonal feedback
Term
indirect acting hormones. they target organ to secrete hormone
Definition
tropic hormone
Term
tropic hormones secreted from the_______
Definition
anterior pituitary
Term
direct acting hormones secreted from ______
Definition
posterior pituitary
Term
examples of tropic hormones
Definition
thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (LTH), and growth hormone (GH or somatotropin).
Term
example of direct acting hormones
Definition
oxytocin

vasopressin (antidiuretic hormone)
Term
uses for hormone therapy
Definition
obtain desired effect

correct deficiency
Term
administered to animal
Definition
exogenous
Term
animal makes the hormone
Definition
endogenous
Term
low hormones trigger hypothalamus to trigger more
Definition
Positive feedback
Term
high hormones trigger hypothalamus to stop secretions
Definition
negative feedback
Term
4 stages of reproductive cycle
Definition
proestrus

estrus

diestrus

anestrus
Term
cause release of or activity like LH and FSH
Definition
gonadotropins
Term
mimics LH in makes and females. treats cystic ovaries in dairy cattle and low testosterone in make animals
Definition
chorionic gonadotropin (hCG)
Term
cases growth/ maturation if follicle. induces super ovulation. for out of season breeding.
Definition
fsh
Term
treats endocrinopathy in ferrets, egg laying in birds
Definition
lupron (luprolide)
Term
secreted from pineal gland. treats alopecia, sleep disorders. improve early breeding/ ovulation in goats and sheep.
Definition
melatonin
Term
name for anterior lobe of pituitary gland
Definition
(adenohypophysis)
Term
name for posterior lobe of pituitary gland
Definition
(neurohypophysis)
Term
reflex applies to the release of oxytocin by the posterior pituitary
Definition
neurohormonal reflex
Term
effects of neurohormonal reflex
Definition
1) stimulation of the udder by a nursing calf or by preparation of the udder for milking, (2) stimulation of the uterus and vagina in parturition, or (3) stimulation of the cerebral cortex by sensory stimuli associated with nursing or milking.
Term
arises from the embryologic pharynx
Definition
anterior lobe of pituitary gland
Term
which arises from the brain.
Definition
posterior pituitary
Term
used to treat cystic (follicular) ovaries in dairy cattle. It has also been used in cats and horses (with limited success) to induce estrus.
Definition
gonadorelin
Term
mimics the effects of LH, although it has limited FSH activity. In males, it stimulates the production of male hormones by the testicles and may facilitate descent of the testicles. is used to treat cystic ovaries (nymphomania) in dairy cattle. In males, it has been used to treat cryptorchidism and infertility caused by low testosterone levels.
Definition
hCG (Chorionic gonadotropin )
Term
induce superovulation and for out-of-season breeding.
Definition
FSH
Term
causes growth and maturation of the ovarian follicle.
Definition
FSH
Term
secreted by the uterus and obtained from the urine of pregnant women. It mimics the effects of LH, although it has limited FSH activity
Definition
hCG (Chorionic gonadotropin
Term
produced endogenously by the hypothalamus. causes the release of FSH and LH by the anterior pituitary.
Definition
Gonadorelin
Term
group of hormones synthesized by the ovaries and—to a lesser extent—by the testicles, adrenal cortex, and placenta
Definition
estrogens
Term
used to treat persistent corpus luteum, to expel purulent material from the uterus, to expel retained placentas and mummified fetuses, and to promote weight gain. In dogs, may be used to control urinary incontinence. In horses, they may be used for induction of estrus in the nonbreeding season.
Definition
estrogens
Term
male sex hormones produced in the testicles, the ovaries, and the adrenal cortex.
Definition
androgens
Term
used to treat urinary incontinence in male dogs

treat anorexia, weight loss, overwork, as nemia, and debilitation.

and to increase libido and fertility in domestic animals (with generally poor results).
Definition
androgens
Term
androgen used for prevention of estrus in dogs.
Definition
mibolerone
Term
produced by the corpus luteum.
Definition
progestins
Term
used clinically to suppress estrus and to treat false pregnancy, behavioral disorders, and progestin-responsive dermatitis.
Definition
progestins
Term
dogs to control estrus, treat false pregnancy, prevent vagi­nal hyperplasia, treat severe galactorrhea, and control unacceptable male behavior. has been used in cats for various dermatologic and behavioral problems and for suppression of estrus.
Definition
Megestrol acetate
Term
used for (1) treatment of behavioral problems, such as aggression, roaming, spraying, or mounting in males, and (2) treatment of certain dermatologic conditions.
human label
Definition
Medroxyprogesterone acetate (MPA
Term
oral progestin labeled for use in horses and swine. This drug is used to suppress estrus in mares and sexually mature gilts.
used to suppress estrus for synchronization, to suppress estrus for long periods, or to maintain pregnancy in mares with low levels of progesterone.
Definition
altrenogest
Term
synthetic progestin that is used in combination with an estrogen (estradiol valerate) for synchronization of estrus in beef cows and nonlactating dairy cows. A treatment consists of one implant and an injection at the time of implantation. Norgestomet is used for synchronization of estrus in cattle.
Definition
norgestomet
Term
progestin used in implants that promotes weight gain
Definition
Melengestrol acetate
Term
used to augment the force of uterine contractions during delivery, aid in delivery of the placenta, facilitate involution of the uterus (for reduction of bleeding or replacement of a prolapse), induce milk letdown, and assist in the treatment of agalactia in sows.
Definition
oxytocin
Term
produces uterine contractions similarly to oxytocin; however, it results in very little vasoconstrictive action. This product is not commonly used.
Definition
ergonovine maleate
Term
treat cysts, mummified fetuses, sync estrus, induce abortion, pyometra
Definition
prostaglandins
Term
can cause induction of parturition in the last trimester of pregnancy. Induction of parturition or abortion is not a labeled use
Definition
corticosteroids
Term
odors released by animals that influence the behavior of other animals of the same species
Definition
pheromones
Term
examples of pheromones
Definition
Feliway, Comfort Zone-Feline are analogues of the feline facial pheromone

boar odor aerosol pheromone that causes the typical boar odor and is used for heat detection in sows and gilts.

dog-appeasing hormone (D.A.P. and Comfort Zone-Canine) mimics the appeasement pheromones, which female dogs secrete to comfort and reassure their nursing puppies
Term
made up of two lobes (one on each side of the trachea) and is located near the cartilage of the larynx.
Definition
thyroid
Term
produced by thyroid
Definition
T3 and T4. T3 is considered to be the active form at the cellular level. Although both T3 and T4 are released from the thyroid gland, some of the T4 is converted to T3 after release. T4, also called thyroxine
Term
drugs for hypothyroidism
Definition
Levothyroxine

Liothyronine sodium (T3

Thyrotropin alpha
Term
synthetic levo isomer of T4. It is the compound of choice for the treatment of hypothyroidism in all species.
Definition
levothyroxine
Term
used for the treatment of hypothyroidism in cases that respond poorly to T4.
synthetic salt of endogenous T3.
Definition
Liothyronine sodium
Term
recombinant TSH. It is used as an aid in the diagnosis of hypothyroidism.used for diagnosis of primary hypothyroidism in the TSH stimulation test.
Definition
Thyrotropin alpha
Term
compound that interferes with incorporation of iodine into the precursor molecules of T3 and T4. It does not alter thyroid hormones already released into the bloodstream.used for the treatment of feline hyperthyroidism.
Definition
methimazole
Term
Most of this drug is converted to methimazole after administration to the cat. It inhibits the synthesis of thyroid hormones. is used for the treatment of feline hyperthyroidism.
Definition
Carbimazole
Term
orally administered, radiopaque, organic iodine compound that is thought to inhibit the conversion of T4 to T3. may be helpful in the treatment of hyperthyroidism in cats that cannot tolerate methimazole or carbimazole.
Definition
ipodate
Term
an antithyroid drug but is considered dangerous for use in cats because of potential hematologic complications
Definition
Propylthiouracil
Term
may be given intravenously to destroy overproductive thyroid tissue. concentrates in the thyroid, where it remains and destroys thyroid tissue.
Definition
I-131 radioactive iodine
Term
may be used preoperatively to treat the tachycardia associated with hyperthyroidism in cats.
Definition
propranolol
Term
2 types of Cushing's
Definition
pituitary dependent

adrenal dependent
Term
benign tumor of the pituitary gland. This tumor causes the pituitary to produce large amounts of ACTH, which stimulates the adrenal to make large amounts of cortisol.
Definition
pituitary dependent hyperadrenocorticism
Term
less common form of the spontaneous disease. It occurs due to a tumor of one or both of the adrenal glands and results in the production of a large amount of cortisol independent of ACTH.
Definition
adrenal dependent hyperadrenocorticism
Term
drugs for Cushing's
Definition
ketoconazole

Metyrapone

Mitotane

Selegiline

trilostane
Term
antifungal agent that can be used in the treatment of hyperadrenocorticism
Definition
ketoconazole
Term
agent used to treat cats with hyperadrenocorticism, especially for stabilization of patients before adrenalectomy.
Definition
metyrapone
Term
used for the treatment of PDH. This agent is an adrenal cytotoxic agent that inhibits or destroys the cortisol-producing layers of the adrenal gland.
Definition
mitotane
Term
monoamine oxidase-B (MAO-B) inhibitor that is used for cognitive dysfunction and PDH in dogs. Its use for Cushing's syndrome is controversial because of disappointing clinical studies
Definition
selegiline
Term
adrenal steroid synthesis inhibitor that may be used to treat PDH or hyperadrenocorticism due to adrenal tumors in dogs
Definition
trilostane
Term
causes decrease in blood glucose level
Definition
insulin
Term
made in beta cells of pancreas
Definition
insulin
Term
causes increase in blood glucose
Definition
glucagon
Term
produced by alpha cells
Definition
glucagon
Term
facilitates cellular uptake of glucose and its storage in the form of glycogen and fat. It inhibits the breakdown of fat, protein, and glycogen into forms that may be used as energy sources. Further, it promotes synthesis of protein, fatty acids, and glycogen.
Definition
insulin
Term
types on insulin
Definition
Short-Acting Insulin - Regular insulin/lispro/aspart

Intermediate-Acting Insulin - NPH/PZI/Lente.

Long-Acting Insulin
Term
fast-acting insulin that is made from zinc insulin crystals; it is a clear solution that may be administered intravenously, intramuscularly, or subcutaneously. It is used mainly to treat diabetic ketoacidosis until blood glucose levels are reduced and the animal is metabolically stable
Definition
short acting insulin
Term
insulin is a cloudy suspension of zinc insulin crystals and protamine zinc. Protamine (a fish protein) and zinc prolong the absorption and activity of the product. They are commonly used for the control of uncomplicated diabetes in dogs and cats.
Definition
intermediate acting insulin
Term
peakless insulin. clear
Definition
long acting insulin
Term
The mechanisms by which estradiol promotes weight gain
Definition
1) increased water retention, (2) increased protein synthesis, (3) increased fat deposition, and (4) possible increased release of growth hormone (bovine somatotropin).
Term
how testosterone promotes growth
Definition
anabolic agent in itself and because a second component in the compound slows down the release of estradiol and prolongs its effective life span.
Term
how progesterone use promotes growth
Definition
slow the release of estradiol. It apparently has little anabolic effect of its own.
Term
synthetic anabolic agent that improves feed efficiency and promotes weight gain in steers. It is used as the sole agent in some growth-promoting preparations.
Definition
trenbolone
Term
how zeranol promotes growth
Definition
analogue of a naturally occurring plant estrogen that increases feed efficiency, protein synthesis, and growth rate.
Term
uses for anabolic steroids
Definition
use in dogs, cats, and horses for anorexia, weight loss, and debilitation.

In working animals, they may be used in cases of overwork or overtraining.

promote red blood cell formation and are used to treat some forms of anemia.
Term
The constructive phase of metabolism in which body cells repair and replace tissue.
Definition
anabolism
Term
chemical compound having a structure similar to another but differing from it in some way.
Definition
analogue
Term
Hyperadrenocorticism; a disease or syndrome characterized by an overabundance of corticosteroid hormones.
Definition
Cushing's syndrome
Term
Difficult birth.
Definition
dystocia
Term
The mucous membrane lining of the uterus.
Definition
endometrium
Term
normal thyroid gland.
Definition
euthroid
Term
The rate at which animals convert feed into tissue. It is expressed as the number of pounds or kilograms of feed needed to produce 1 lb or 1 kg of animal.
Definition
feed efficiency
Term
The return of some of the output product of a process as input in a way that controls the process.
Definition
feedback
Term
A hormone that stimulates the ovaries or testes.
Definition
gonadotropin
Term
This is the portal system of the pituitary gland in which venules from the hypothalamus connect with capillaries of the anterior pituitary.
Definition
hypophyseal portal system
Term
Caused by the physician (veterinarian).
Definition
iatrogenic
Term
The return of a reproductive organ to normal size after delivery.
Definition
Involution
Term
Left-sided arrangement of a molecule that may exist in a left- or a right-sided configuration. Levo and dextro isomers have the same molecular formula.
Definition
levo-isomer
Term
muscle fibril composed of numerous myofilaments.
Definition
myofibril
Term
The condition of the body as it relates to protein intake and use. Positive nitrogen balance implies a net gain in body protein.
Definition
nitrogen balance
Term
Hypothyroidism resulting from a pathologic condition in the thyroid.
Definition
primary hypothyroidism
Term
hormone produced by the hypothalamus and transported to the anterior pituitary to stimulate the release of trophic hormones.
Definition
releasing factor (releasing hormone)
Term
A hormone that results in production of a second hormone in a target gland.
Definition
trophic hormone
Term
promote tissue anabolism, rbc formation, weight gain
Definition
androgens
Term
must be primed with estrogen as progesterone
Definition
oxytocin
Term
signs of hyperthyroidism
Definition
weight loss

hyperexcitability

tachycardia

increased appetite
Term
signs of hypothyroidism
Definition
weight gain

lethargy

dry skin

poor hair coat

bradycardia
Term
things to educate clients on regarding insulin
Definition
feed 30 minutes before

roll insulin

inject sq (flank, side of chest or abdomen)

rotate injection sites

recognize hypoglycemia signs

don't give in thigh, belly or neck
Term
hypoglycemic drugs that lower blood sugar
Definition
metformin

glipizide
Term
increased milk production, lowers growth rate
Definition
bovine somatotropin (bst)
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