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HLTH331 - FINAL UP IN DIS DUN NOE
WORDS ON DA PAPER
205
Gardening
Kindergarten
04/25/2013

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Cards

Term
Lactation
Definition
Production and secretion of breast milk by mammary glands
Term
What hormone controls milk production vs. milk let down?
Definition
PROLACTIN = milk production

OXYTOCIN = milk let down
Term
In the first few days after pregnancy, produce __________; immature mik rich in ______ and _______ for infant
Definition
Produce COLOSTRUM

Rich in PROTEINS and IMMUNE FACTORS
Term
How much milk is produced per day?
Definition
About 25 oz (> 700 mL)
Term
How much energy is produced in milk during lactation?
Definition
25 oz = 750 mL = 3 cups --> 500 kcal of energy
Term
Additional energy intake by lactating mothers in first 6 months vs. after that?
Definition
1st 6 months = 330 kcal/day

after that = 400 kcal/day
Term
AI for total water in lactating mothers?
Definition
3.8 L (need 3.1 L of that to be from liquid sources)
Term
Nutritional inadequacy impacts the ___________ of milk produced more than the ___________
Definition
Greater impact on QUANTITY, NOT QUALITY
Term
Canada guide to breast feeding:
How long for exclusive feeding?
How long for feeding w/ complementary food?
Definition
EXCLUSIVE = 6 months

Complementary food = 1 year
Term
When lactating/breastfeeding CANNOT:
Definition
Drink EtOH (if so, wait at least 2 h)
Smoke
Some medications
Consume Hg
Caffeine (no more than 2 cups/day)
Term
Infants need ___________________ kcal/kg of weight per day
Definition
Need 100 kcal/kg of weight per day
Term
Rate of weight and height increases in infants in the first year?
Definition
Birth weight has tripled after 1st year
Usually length has increased by 50%
Term
Main protein present in breast milk?
Definition
Alpha-lactalbumin
Term
Main fat content in breast milk?
Definition
Linoleic, linolenic, arachidonic acids, DHA
Term
Composition of BREAST MILK (% of each macromoc)?
Definition
40% CARBS
54% FAT
6% PROTEIN
Term
Composition of Infant Formula?
Definition
42% CARBS
49% FAT
9% PROTEIN
Term
Compared to breast milk, formula contains more _______ and less ______
Definition
Formula has a greater % - PROTEIN & CARBS

Formula has a lower % - FAT
Term
Breastfed infants may be at risk for deficiencies in ....
Definition
Vit D
Vit K
Fe
Term
Vit D supplementation in breast feeding infants?
Definition
10 ug/day

20ug/day if north of Edmonton in winter
Term
Vit K deficiency risk in breastfeeding infants?
Definition
SHOULD get single intramuscular injection (0.5-1 mg) within first 6 hours
Term
Fe AI in breastfeeding infants?
Definition
First 6 months = 0.27 mg/day
Afterwards = 11 mg/day

May need Fe fortified foods to meet needs
Term
Water needs in infants (AI)
Definition
0-6 mos = 0.7 L/day

7-12 mos = 0.8 L/day
Term
Compounds present in COLOSTRUM
Definition
Oligosaccharides
Bifidus factors (probiotic growth)
Lactoferrin - aid Fe absorption
Lactadherin - inhibit viral replication
Term
_____________ is present in colostrum and inhibits replication of viruses causing infant diarrhea
Definition
LACTADHERIN
Term
In experiment w/ breastfed vs. probiotic formula vs. control formula, what did results show?
Definition
BF was best - increased # of bifidobacteria (good); decreased # of enterobacteria & clostridia (bad bacteria)
Term
When should honey be fed to infants?
Definition
NOT before 1 year (avoid in case of unpasteurized honey)
Term
Fluid milk introduced to infant at __________ because of __________
Definition
Intro'd at 1 YEAR

Because of low Fe and digestive problems
Term
Difference between allergy & intolerance?
Definition
Allergy - hypersensitivity reaction from immune system

Intolerance - digestive problem
Term
Prevalence of food allergies?
Definition
3.5% prevalence in US

Peanut allergy prev = 1%
Term
Steps involved in IgE hypersensitivity rxn cascade...
Definition
B & T cells mobilize
T cells - differentiate to Th2 cells; stimulate B cells to make antibodies
Antibodies prime mast cells - if antigen binds to primed mast cells, degranulates to release prostaglandins, leukotrienes, histamine
Term
Immune factors released by primed mast cells?
Definition
Leukotrienes, Prostaglandins, Histamine
Term
_______ = specific peptide domain with a protein responsible for allergic potential; binds IgE and causes degranulation
Definition
EPITOPE
Term
How does the AMDR for FATS change with age?
Definition
0-12 mos = 40-55%
1-3 yrs = 30-40%
4-18 yrs = 25-35%
Term
What AMDR for a macronutrient is the same in ALL age groups (1-3, 4-18, >18)?
Definition
CARBS = 45-65%
Term
Vit D assists in bone development because it increases ______________
Definition
Increases INTESTINAL Ca ABSORPTION
Term
How does Vit D increase intestinal Ca absorption?
Definition
Upregulates synthesis of intestinal Ca transport proteins
Term
If Ca levels are high _________ is released from __________
Definition
Calcitonin is released from THYROID

DECREASES [Ca]
Term
If Ca levels are low ____________ is released from _________
Definition
PTH is released from PT glands

PTH increases [Ca]
Term
Peak bone mass is achieved by about _____________ yrs of age
Definition
Around 16-20 yrs of age
Term
Why are women at a greater risk for osteoporosis?
Definition
Have a LOWER PEAK BONE MASS

Have ACCELERATED decline of BMD after menopause
Term
Key risk factors for bone fracture?
Definition
Low BMD (primary)
Prior fracture/family history of osteoporotic fracture
Long term use of glucocorticoids (prednisone; NSAIDs)
Age
Term
Long term use of _____________ can increase risk of osteoporosis?
Definition
GLUCOCORTICOIDS (e.g. prednisone)
Term
Osteopenia/osteoporosis prevalence in women vs. men > 50?
Definition
Much higher in women

Almost similar ranges of osteopenia incidence
Much higher incidence of osteoporosis in women > 50
Term
Hemiarthroplasty
Definition
Surgery for femoral neck fracture; replace part of the neck of the femur
Term
Direct medical costs of treating osteoporotic fractures.....
Definition
Estimated at 13.8 billion $
Term
Which spine fractures are the most symptomatic and disabling?
Definition
THORACIC SPINE (much worse than those in lumbar spine)
Term
Nutrient density is important in feeding in children because?
Definition
Small energy needs/Large nutrient needs
Small appetite
Term
Breakfast study w/ attention & memory?
Definition
Shreddies, Cheerios, Glucose, NONE (each had 30-40 g of carbs)

BEST = Shreddies & Cheerios - need complex carbs in morning
In ALL conditions, see decreased performance in memory and attention over time from meal (glucose and no meal were worst)
Term
Lead toxicity is particularly common in children because....
Definition
Pb absorption is more efficient in children
Term
How can Pb absorption be enhanced?
Definition
Pb absorption enhanced if child is MALNOURISHED (empty stomach, Ca, Zn, Fe deficiency upregulate Pb absorption)
Term
Pb interferes with ____________
Definition
Interferes with NEUROTRANSMITTER FUNCTION (learning disabilities, behavioral issues)
Term
Highest Pb levels in ________ children

Lowest Pb levels in _________ children
Definition
Highest = black, non-Hispanic

Lowest = white, non-Hispanic

Have generally been on decline since 1991 though
Term
A _________________ program is a school based health promotion framework going beyond the classroom and has a more integrated approach; involves ________________
Definition
A COMPREHENSIVE-SCHOOL HEALTH program

Includes = education & whole-school environment
Term
APPLE Schools = ?
Definition
Part of the comprehensive-school health program
Alberta Project Promoting active Living and healthy Eating
Term
Effects on students going to APPLE SCHOOLS:
Definition
Eat more fruits & veggies
Eat fewer calories
More physically active
Less likely to be obese
Term
When was the APPLE project launched?
Definition
In 2008 by School of Public Health at U of A (3 yr intervention)

LIMITATIONS - self-report (biases)
Term
____% of all Canadian girls do not meet requirements for Fe
Definition
12%
Term
More girls than boys do not meet requirements for the mineral _____
Definition
Ca

70% of girls vs. 30% of boys
Term
What is aging?
Definition
The inevitable accumulation of changes that are associated with and responsible for increasing susceptibility to disease + death; loss in cell # and function
Term
Young Old vs. Old Old vs. Oldest Old?
Definition
Young Old = 65-74
Old Old = 75-84
Oldest Old = 85 and older
Term
Physiological vs. Chronological Age?
Definition
Physiological = age expected from body health & life expectancy
Chronological = age in years from birth
Term
Life Expectancy vs. Life Span
Definition
Expectancy = AVERAGE length of life for population

Span = MAX # of yrs of life attainable by member of species; currently at 122 yrs for humans
Term
What is "compression of morbidity"?
Definition
Want to age well and not have significant morbidity over last 10-15 yrs of life
Compression of morbidity indicates you can maintain good health and die SUDDENLY (don't have long period with disability)
Term
Life expectancy of women vs. men?
Definition
Women = 82 yrs

Men = 77 yrs
Term
Life expectancy of women vs. men?
Definition
Women = 82 yrs

Men = 77 yrs
Term
Kcal Restriction
Definition
Experimental treatment used to increase lifespans in a # of mammalian species
Usually reduce kcal intake to 70% of normal amount which appears to slow aging-related processes
Term
Two different beliefs to what causes aging?
Definition
Programmed cell death - death triggered when genes that disrupt cell function are activated; support = lab cells only grow certain # of times

Wear & tear - aging due to accumulation of cellular damage from errors in DNA handling, free radicals, etc.
Term
Increase in longevity from kcal restriction in mammals may be due to ________
Definition
Reduction in oxidative stress (reduced O2 consumption, less oxidative stress)
Term
Caloric restriction delays disease onset in rhesus monkeys....what up with dat.
Definition
Reduced kcal content by 10% each month over 3 months (30% total reduction)
Lower body weight in CR, but same lean muscle mass
Decreased atrophy in CR brains in motor and exec f areas
Better survival, less chronic disease incidence, more animals without age related disease
Term
Benefits of kcal restriction in rhesus monkeys:
Definition
Less body weight, same lean mass
Decreased atrophy in motor and exec function areas
Less chronic disease, less age-related disease
Better survival = longer expectancy
Term
Okinawans have the longest life expectancy in the world at _____ yrs of age
Definition
81 yrs
Term
How to calculate HHR?
Definition
HHR = heart rate reserve = max HR - resting HR
Term
Results - effects of exercise on cognitive function in elderly?
Definition
Improved VO2 max by 11%
Improved insulin sensitivity (WOMEN only)
Improved exec function (ESPECIALLY IN WOMEN)

Gender differences may be due to differences in glucose metabolism
Term
Calculate 85% of HHR for 80 yr old; resting HR = 75
Definition
HHR = max - resting
Max = 140; HHR = 65
0.85 x 65 = 55, so 55 + 75 = 130 (85% HHR)
Term
Effects of exercise on fall risk in elderly?
Definition
In AGILITY and RESISTANCE groups - had significantly lower fall risk score; NO improvement in stretching (sham) condition
Term
Teenagers eat __________ healthily compared to elderly
Definition
LESS
Term
Teenagers eat __________ healthily compared to elderly
Definition
LESS
Term
Energy needs are decreased in the elderly because of lower...
Definition
BMR and TEF
Term
Estimating daily energy requirements for WOMEN vs. MEN of older age; take daily requirement of 30 yr old...
Definition
WOMEN - subtract 7 kcal for each year over 30

MEN - subtract 10 kcal for each year over 30
Term
Changes in fibre AI with age?
Definition
Men; less than 70 = 38 g; more than 70 = 30 g

Women; less than 70 = 25 g; more than 70 = 21 g
Term
In elder age need increased intake of...
Definition
B6, B12, Mg, Ca
Term
Why is there reduced absorption of Vit B12 with age?
Definition
Atrophic gastritis - inflammation of stomach reduces stomach acid, in severe cases reduces IF release
Term
Neurological symptoms in B12 deficiency are caused by _______
Definition
Myelin degeneration

B12 required to synthesize methionine derivative, part of myelin sheath
Term
B12 is needed to synthesize a methionine derivative, a component of __________
Definition
The myelin sheath

B12 deficiency = myelin degeneration
Term
Prevalence of atrophic gastritis in the population
Definition
10-30% of population over 50 yrs of age

40% of population over 80 yrs
Term
How does atrophic gastritis lead to B12 deficiency?
Definition
Decreased production of stomach acid and IF

Microbe growth competes for B12 binding with IF
Term
Supplementation of Vit D in those over 50?
Definition
Supplement with 10 ug/day
Term
Increased RDA of Ca in elderly?
Definition
Increased to 1200 mg
Term
Fe needs in post-menopausal women?
Definition
DECREASED - due to decreased Fe loss after menopause (don't lose as much because no more menses)
Term
2 causes of Fe deficiency?
Definition
Blood loss
Poor absorption from low stomach acid (atrophic gastritis, antacid use)
Term
Change in hunger related hormones with age...
Definition
INCREASED - CCK and LEPTIN

DECREASED - GHRELIN, GI MOTILITY


NET EFFECT - decrease in hunger & appetite
Term
Aerodigestive Tract
Definition
40 muscles bilaterally activated by 6 cranial nerves
Term
Swallowing reflex is initiated by.....
Definition
Pressure on the pharynx

Afferent signals to medulla; medulla sends efferent signals to pharynx, esophageal, and respiratory muscles
Term
Presbyphagia
Definition
Healthy, age-related changes in swallowing; characteristic age-related changes in swallowing
Term
Events occurring in presbyphagia:
Definition
REDUCED functional reserve
Decreased lingual pressure generation; slowed initiation of automatic swallowing
Xerostomia - decreased salivary reserve
Sensory changes - reflex may not be triggered by same pharyngeal pressure, may need more
Sarcopenia of upper GI tract
Term
Xerostomia
Definition
Decreased salivary reserve; seen in presbyphagia as # of salivary cells decreases in mouth
Term
Sarcopenia
Definition
Degeneration of skeletal muscle with age
Term
Believed cause of cataracts?
Definition
Oxidative stress
Term
In the aging brain see...
Definition
Decreased cerebral perfusion (reduced blood flow)
Decreased # of neurons

Consume fish to maintain executive function (get EPA and DHA intake to preserve functional reserve)
Term
Prevalence of food insecurity in Canadians > 65?
Definition
2.5%
Term
Effect of amphetamines vs. corticosteroids on appetite?
Definition
Amphetamines = SUPPRESS appetite

Corticosteroids = STIMULATE appetite
Term
Nausea can be caused by 2 types of drugs...
Definition
Digoxin
Codeine
Term
__________ are known to cause mucosal damage to GI tract
Definition
NSAIDs
Term
Tetracycline may impair absorption of ______
Definition
CALCIUM
Term
Isoniazid requires ________ supplementation when taking
Definition
B6 supplementation

Isoniazid is similar to B6 in structure and interferes with conversion to active form
Term
Food Safety
Definition
Degree of risk of becoming ill due to food consumption; all hazards (chronic & acute) that can make food injurious to consumer
Term
Food Quality
Definition
All other NON-safety attributes that influence product's value - taste, appearance, etc.
Term
Internal T of a cooked hamburger should reach...
Definition
71 degrees C
Term
Protocols in place for Hazard Analysis Critical Control Point (HACCP) principles...
Definition
Used by CFIA

Hazard analysis
ID critical control points
Establish control limits
Monitoring procedures & corrective actions
Verification procedures; documentation & record keeping procedures
Term
Critical control point of egg production?
Definition
Pasteurization - get rid of Salmonella
Term
Best before date / use by date must be on foods that are fresh for less than...
Definition
90 days
Term
Types of food safety technology...
Definition
Pasteurization
Irradiation
Packaging
Term
If milk is not pasteurized, can get________
Definition
bovine Tb
Term
Irradiation is used to control _________
Definition
Mould in grain
Sterilize spices and teas
Delay ripening
Destroy bacteria in meats
Term
Does food irradiation make food radioactive?
Definition
NAH SON. DAS SILLY.
Term
Most common sources of Salmonella?
Definition
Chicken and eggs

Use refrigeration to slow growth; present from contamination from animal feces
Term
To destroy E. coli cook to internal temp of?
Definition
71 degrees C (160 degrees F)
Term
Most deadly foodborne toxin ?
Definition
Botulism (Clostridium botulinum)
Term
Sources of botulism?
Definition
Improper canned foods (discard cans if bulging)
Term
Sources of infant botulism?
Definition
Unpasteurized honey - dont give before 1 yr old!
Term
Infection timeline of norovirus/gastroenteritis?
Definition
Virus attaches to intestinal cells, injects nucleic acids in which use host transcription/translation machinery to make new viruses
Cells rupture and cycle repeats


CAN kill noroviruses through cooking
Term
Garidia lamblia is the common cause of ....
Definition
Traveler's diarrhea
Term
Trichinella spiralis is a _________ present in __________
Definition
PARASITE present in raw/undercooked pork and game meats
Term
Mycotoxins
Definition
Toxins produced by moulds
Term
Effect of cooking/freezing on mycotoxins (from moulds)?
Definition
STOP GROWTH, but do not remove

E.g. Ergot mycotoxins are hallucinogens found in contaminated rye
Term
How do prions cause pathogenesis?
Definition
Prions = misfolded proteins; cause misfolding of adjacent proteins, aggregate and form plaques which lead to pathology
Term
Can only evaluate presence of prions....
Definition
POST-MORTEM
Term
Disease progression from scrapie to vCJD
Definition
Scrapie in sheep, cattle fed with sheep containing prion from scrapie - caused BSE
Humans ate beef contaminated with prion and caused vCJD
Term
What is the DANGER ZONE?
Definition
the set of ARCHER

BUT ACTUALLY, its 4-60 deg C y'all
Term
Freezer should be kept at a T of ?
Definition
-18 deg C
Term
Main concern with food safety & allergies?
Definition
LABELING

Large heterogeneity in risk associated with food; have new labeling procedures that require all ingredients listed, even if at smaller quantities than previously needed
Term
Bioaccumulation
Definition
Accumulation of toxins within organisms increases with each successive step of being passed on

E.g. water contaminants exist in higher concentrations in large fish compared to algae or smaller fish
Term
Max Residue Limit
Definition
Applies to pesticides; max amount of pesticide residues that may legally remain on a food (set by Health Canada)
Term
Amount of pesticide residue on domestic vs. imported foods?
Definition
IMPORTED - more residue that would exceed max limit

DOMESTIC - more proportion of residue overall, but at levels below tolerance/max limit
Term
FAT TOM acronym for preservatives
Definition
Fat
Acidity
Temperature
Time
Oxygen
Moisture
Term
1/100 Margin of Safety
Definition
For food additives; additive is allowed at levels 100x below that found to cause harmful effects
Term
Examples of antimicrobial preservatives
Definition
Salt, sugar
Bacteriophages (can destroy Listeria)
Term
MSG symptom complex
Definition
Flushing of face & chest; pain in face & chest; headache
Term
Aspartame structure
Definition
Phe + Aspartic Acid + Me group

BE WARY of those with PKU (can't eat things with Phe)
Term
Acceptably daily intake of aspartame?
Definition
40 mg/kg of body weight

97 packs of sweetener, or 16 cans of soda in 90 kg adult
Term
What is acrylamide?
Definition
Indirect food additive - forms when carb rich foods and asparagine are cooked; high doses = cancer + nerve damage
Term
What polycarbonate is banned from plastic baby bottles?
Definition
Bisphenol A
Term
# of GM crops in 2008? Predicted # by 2015?
Definition
2008 = 30 GM crops in 25 countries

>120 by 2015
Term
Corn and cotton are engineered to express proteins from _______________ to kill insects
Definition
Bacillus thurigiensis (Bt)

Little or no harm to non-target animals
8% reduction in insecticide use
Term
Glycophosphate
Definition
Used to block ENZ required for plant production of Trp; no effect on animals
Engineered plants to become Glycophosphate-Resistant
Allows for low till/no till agriculture
Term
What are the criteria needed for the ORGANIC label?
Definition
Contains single/multi ingredient food with organic content AT LEAST 95%
Term
x% organic ingredients - criteria?
Definition
Need % to be between 70 and 94%; don't get organic logo
Term
Goals of genetic modification?
Definition
Increase shelf life
Increase nutrients (biofortification)
Decrease herbicide/pesticide use
Term
Golden rice - GM crop
Definition
have modified to contain beta-carotene - rice should have a higher Vit A content; BIOFORTIFICATION with B-carotene (GM example)
Term
Superbugs
Definition
Bugs that are resistant to pesticide (made from GM plant or sprayed); will be more successful than non-resistant bugs
Term
Superweeds
Definition
Weeds that have cross bred with GM plants that have certain growth advantages
Term
Biodiversity
Definition
Preferred crops; crops preferred, whether GM or not, can limit biodiversity
Term
GLOBAL SEED VAULT
Definition
Located in Svalbard (Norway); halfway up a mountain

Contains the meaning of life and the fossil recording of the 1967 stanley cup victory
Term
Need to increase agricultural production by _______ by 2030 to meet demands
Definition
50%
Term
Problems with attempting to increase agriculture production?
Definition
Have limited land available - no extra
Fresh water availability is decreasing


Need to produce more on the same amount of land with less H2O
Term
How does irrigation cause environmental damage?
Definition
Salinization increases salt content of soil; makes soil less productive
Term
In industrialized countries, how much of energy use is due to food production?
Definition
17%
Term
How far is food (on avg) transported before it is eaten?
Definition
2414 km (approx distance from Winnipeg to Kingston)
Term
Farming is responsible for _______% of pollution of US water
Definition
70%
Term
How large is the global livestock herd?
Definition
> 3 billion
Term
Extensive vs. Intensive land for livestock
Definition
Extensive - RANGELANDS

Intensive - FEEDLOT
Term
Frontier Economics
Definition
Progress understood simply as boundless economic growth and prosperity; based on exploitation of natural resources perceived as equally limitless
Term
What is responsible for 80% of rainforest deforestation?
Definition
Cattle grazing fields - majority of deforestation occurs for this reason
Term
Sustainable/Sustainability
Definition
Able to continue indefinitely
Using resources at a rate at the Earth can continually replenish
Polluting air at a rate = or less than rate that environment/us can clean up
Term
Sustainable Agriculture
Definition
Ability to produce food INDEFINITELY with little/no harm to environment
Term
What is eco-efficiency?
Definition
Related to both ecology and economy; needs to be resource efficient and sustainable for the environment
Term
What is considered to be an "increase in eco-efficiency"?
Definition
Production level achieved with fewer resources, less losses to environment without sacrificing productive potential of land or economic success
Term
Crop Rotation
Definition
Farming different plants each year, or different plants in different parts of year; improves health of soil and decreases erosion
Term
Areas involved in sustainable farming
Definition
Crop rotation/soil quality
Soil erosion management (terracing)
Minimal pesticide use with BM crops
Livestock
Term
Problem with planting the exact same crop every year?
Definition
Depletes soil of nutrients and increases # of soil borne pathogens
Term
What are the reasons for low use of mixed crop + livestock?
Definition
Price of moving manure may be more than buying fertilizer
Increased management complexity
Potential for poor financial return
Increased fertilizer cost
Term
Sustainable Animal Farming
Definition
Perennial forage crops decrease erosion (make sure NOT overgrazed)
Dense root systems = filters to remove H2O contaminants
Deep root systems = improve water & air movement
Term
Benefits of dense vs. deep root systems?
Definition
Dense - remove contaminants from water

Deep - increase water and air movement
Term
Food Insecurity
Definition
Situation in which people lack adequate physical, social, or economic access to sufficient, safe, and nutritious food that meets dietary needs for active and healthy lives
Term
Food insecurity is experienced by....
Definition
3 million Canadians

33% of Aboriginal households
Term
In 2003 data, what % of Canada was food insecure?
Definition
9.2% (mostly moderate, 2.9% severely)

Due to INADEQUATE RESOURCES to purchase food
Term
Food insecurity is due mainly to..
Definition
INADEQUATE RESOURCES TO PURCHASE FOOD, not that food is not present
Term
What has dependence shifted towards in isolated Northern communities?
Definition
Store bought food, shifted away from locally produced food

Lack of year round access increases cost and necessitates air transport; decreases quality of food
(Same meal in BC = $16, northern = $35)
Term
Households that are more food insecure are more likely to have children who are _________________ in the morning
Definition
NOT EATING BREAKFAST
Term
Demands on food banks are ________
Definition
INCREASING
Term
Field Gleaning
Definition
Harvest food left behind after automated harvesting
Term
Kingston Food Bank Facts
Definition
789 new clients in 2009
Almost 6000 individuals served each year; almost 1/2 are children under 18
30% of users are single parents
22000 lbs of food donated on regular basis
Term
Approximately how many people worldwide are chronically undernourished?
Definition
1 billion

6 million children die each year due to undernutrition
Term
Causes of world hunger...
Definition
Unrest - destabilize food supplies
Over population for resources
Poverty

and most importantly...BENJI
Term
_______ people have Fe deficiency anemia
Definition
2 billion; can lead to maternal death, premie birth, low birth weight
Term
Diagnosis for Fe deficiency anemia requires...
Definition
Low serum FERRITIN
High TRANSFERRIN, low saturation
Low [Hb], Hct
Term
__________ people globally have insufficient IODINE intake?
Definition
1.9 billion
Term
Thyroid hormones?
Definition
T4 = thyroxine

T3 = triiodothyronine (active)
Term
What converts T4 to T3?
Definition
Se-containing ENZ within thyroid cells
Term
How do T3 hormones exert effect?
Definition
Bind to protein complexes and act on DNA in nucleus to alter transcription and protein levels
Term
Vit A deficiency present in > _________ million children
Definition
250 million
Term
Preformed vit A = ?
Examples = ?
Definition
RETINOIDS

Retinol, retinal, retinoic acid
Term
Provitamin A = ?
Examples?
Definition
CAROTENOIDS
B-carotene, a-carotene, B-cryptoxanthin
Term
________ vit A is absorbed more easily than __________ vit A
Definition
PREFORMED VIT A is more easily absorbed than PROVITAMIN A
Term
Vit A is transported in _______ in the body
Definition
CHYLOMICRONS
Term
Vit A and vision in the retina
Definition
Retinol bound to opsin = rhodopsin; in cis conformation

When light strikes, retinol changes to trans formation, dissociates with opsin
If Vit A levels are inadequate, get night blindness b/c not enough retinol
Term
How does Vit A regulate gene expression?
Definition
Binds to protein complex and controls transcription and translation processes
Term
Xerophthalmia = ?
Definition
NIGHT BLINDNESS
Term
Vit A & epithelial tissue...
Definition
In deficiency - epithelial cells differentiate abnormally (mucus secreting epithelium die and replaced by improper keratin secreting cells = keratinization)
Term
Marasmus vs. Kawarshiorkor?
Definition
Marasmus = chronic PEM

Kawarshiorkor = acute PEM
Term
differences in body composition in acute vs. chronic PEM?
Definition
Acute - underweight for height; kwarshiorkor

Chronic - short for age (stunted growth); marasmus
Term
Origin of word Kwarshiorkor?
Definition
Ghanian word; describes illness child develops when next child is born

Occurs at 18-24 months, during transition from breastfeeding to low-protein cereal diet
Term
Symptoms of Kwarshiorkor?
Definition
Fatty liver, decreased liver ENZ - not enough protein transporters to transport fat
Edema in limbs and abdomen
Impaired immunity
Term
Ugandan school children study?
Definition
Those in MOST poor group consumed fewest meals; those in MOST poor group performed academically worse than other groups
Achievement significantly associated with consumption of breakfast & midday meal
Term
Difference in rural traditional diets vs affluent western diets?
Definition
Rural - low fat & sugar; high fibre; CHO staples; lead to undernourishment
Western - high fat & sugar; low fibre; high in animal protein; lead to overnourishment, chronic disease later in life
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