Term
| Interfere with cell cylce activated by lymphoid cells. In monocytes, they inhibit IL-1 production, which inhibits IL-2 and INF gamma |
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Definition
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Term
| Immunosuppressive drug used in Al disorders: ITP, SLE, AIHA, GN, and IBD |
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Definition
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Term
| Used in cancer with pulse regimen with high doses. Immunosuppressive at low doses. |
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Definition
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Term
| Adverse effects increase with high dosage which include osteoporosis (elderly) and peptic ulcers |
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Definition
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Term
| Transformed into hydroxylated intermediates phosphoramid mustard and aerolein. PM alkylates the DNA |
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Definition
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Term
| USe: Al disorders such as SLE, factor 13 Ab, AIHA. Does not prevent graft vs. host. |
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Definition
| Cyclophosphamide (compared to Antilymphocyte/antithymocyte Abs which are used for GvH) |
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Term
| Causes Hemorrhagic cystitis and pancytopenia |
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Definition
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Term
| Decreases phosphatase enzyme for T cell activation. Binds to cyclophilin, complex binds to CALCINEURIN, dephosylates NFATC, decreasing IL-2 |
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Definition
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Term
| Kidney, liver, and cardiac transplants |
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Definition
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Term
| P-glycoprotein efflux and CYP3A$ metabolism decrease cyclosporine absorption. Grapefruit lowers Cyp34A |
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Definition
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Term
| Nephrotoxic, hepatotoxic, osteoporosis. Gingivial hyperplasia and hirsutism |
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Definition
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Term
| Inhibits calcineurin by binding to FKBP-12 instead of Cyclophilin (cyclosporin). Also more potent |
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Definition
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Term
| Only drug required in hepatic transplant, also used along with glucocorticoids for liver and kidney rejections |
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Definition
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Term
| Nephrotoxic and neurotoxic, no Hirsutism or ginbival hyperplasia |
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Definition
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Term
| Inhibits purine synthesis. Inhibits IMP dehydrogenase, blocks GMP (Both B and T depressio) |
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Definition
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Term
| Used in combo with prednisone for Kindney and liver transplants |
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Definition
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Term
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Definition
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Term
| Inhibits purine synthesis, cytotoxic drug that kills stimulated T cells. |
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Definition
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Term
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Definition
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Term
| Prolonged half life from ALLOPURINOL |
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Definition
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Term
| USED in RA chrons, MS, renal SLE |
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Definition
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Term
| pyrimidine synthesis inhibitor, M1 metabolite inhibits DHODH, an mytochondrial enzyme that catalyzes key step in pyrimidine synthesis |
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Definition
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Term
| BIg use in RA, also renal and organ transplants |
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Definition
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Term
| Blocks IL-2 stimulated cell proliferation, T-cell Immunosuppressor |
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Definition
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Term
| Marolid from streptomyces |
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Definition
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Term
| Used in Kidney and heart allografts, psoriasis, uveitis |
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Definition
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Term
| Blocks IL-2 stimulated cell proliferation. Forms complex with FKBP-12 which blocks mTOR(mammilian target of rapamycin) |
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Definition
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Term
| Renal transplants with cyclosporine and corticosteroids |
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Definition
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Term
| Destroys t lymphocytes and works on all Tcells |
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Definition
| Antilymphocytes and antithymocyte Abs |
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Term
| Excellent for Graft vs. Host, also useful as a prophylactic in pre-sensitzed patients in treatment of steroid-resistant acute rejections. |
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Definition
| Antilymphocytes and antithymocyte Abs |
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Term
| Sides include abs against proteins causing FVs, chills, leukopenia, thrombocytopenia, and a rash |
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Definition
| Antilymphocytes and antithymocyte Abs |
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Term
| Murine mab against CD3 on all lymphocytes |
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Definition
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Term
| Reverses the renal allograft rejection crisis |
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Definition
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Term
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Definition
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Term
| Useful in combo with Sirolimus in patients who cannot used steroids |
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Definition
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Term
| Blocks IL-2Ralpha, (CD25) competitively inhibiting IL-2 |
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Definition
| Basiliximab and Daclizumab |
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Term
| More humanized version (Basiliximab or Daclizumab) |
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Definition
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Term
| Is comparable to placebo in myelosuppression and drug interactions |
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Definition
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Term
| Similar to Tacrolimis and more effective. Used to prevent atopic dermatitis |
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Definition
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Term
| Decoy for autoantibodies that attack myelin sheaths in MS |
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Definition
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Term
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Definition
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Term
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Definition
| Etanercept and Infliximab |
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Term
| Severe Psoriasis, Chrons, and RA. Sides include CNS and seizures. |
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Definition
| Etanercept and Infliximab |
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Term
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Definition
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Term
| Treatment of mod-severe chronic plaque psoriasis |
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Definition
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Term
| Antibody against D antigen of RBCs, prevents erythroblastosis fetalis, and hymolytic disease of the newborn |
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Definition
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Term
| Intercalates between G-C. Blocks RNA/DNA polymerase |
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Definition
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Term
| P-glycoprotein efflux of the drug out of cells |
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Definition
Dactinomycin
Doxorubicin
Duanorubicin |
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Term
| ABVD regiment (A). Intercalates in DNA, blocking synthesis, also chelates |
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Definition
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Term
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Definition
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Term
| G2 phase, Intercalates DNA, Inhibits Tropiosomerase II, chelates iron |
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Definition
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Term
| Causes pulmonary toxicity leading to hypoxia and death |
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Definition
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Term
| Chelator used as a cardioprotector, administered with anti-cancer Antibiotics |
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Definition
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Term
| MOPP, used for solid tumors and leukemia. Side effect of GI distress |
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Definition
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Term
| Crosslinks DNA at guanine N-7, activated by hepatic oxidase enzyme turning into phospharamide mustard and acrolein |
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Definition
| Cyclophosphamide and Ifosfamide |
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Term
| Causes Hemorrhagic Cystitis |
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Definition
| Cyclophosphamide and Ifosfamide |
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Term
| Lipophilic and crosses BBB used in brain tumors...Alkalates DNA |
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Definition
| Nitrosoureas (carmustine and Lomustine) |
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Term
| Leukopenia, dizzy/ataxia, and myelosupression |
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Definition
| Nitrosoureas (carmustine and lomustine) |
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Term
| Alkylation at guanine N-7, selective suppression of granulocytopoiesis |
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Definition
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Term
| Causes Pulmonary Fibrosis, decrease BM depression |
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Definition
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Term
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Definition
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Term
| Interferes with folate synthesis by binding to DHFR. Decreases thymidine and purine synthesis |
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Definition
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Term
| Leucovorin Recovery, myelosuppression, alopecia, abortion, ectopic pregnancy, psoriasis |
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Definition
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Term
| Purine linked to sulfur base analogue. Activates HGPRT, incorporated into DNA/RNA |
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Definition
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Term
| Used for ALL, causes myelosuppression and focal central necrosis. ALLOPURINAL increases half life |
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Definition
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Term
| Pyrimidine base analogue of DNA/RNA. Prematurely disrupts. decreases dTMP |
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Definition
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Term
| Slow growing solid tumors, treats colorectal, breast, pancreatic, gastric. Sides include photosensitivity and myelosuppression |
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Definition
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Term
| Cytosine analogue inhibiting DNAP/RNAP |
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Definition
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Term
| Used in Leukemia-ALL, AML, CML. SIDES include ataxia, cerebellar disorders |
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Definition
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Term
| M phase arresting, Blocks tubulin polymerization of spindles. Part of ABVD |
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Definition
| Vincristine/Vinblastine/Vinorelbine |
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Term
| Causes peripheral neurotoxicity |
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Definition
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Term
| Polimerization and Stabalization of microtubules but inhibits disassembly |
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Definition
| Taxanes (paclitoxel and Docetoxel) |
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Term
| Used in metastic breast cancer, advanced enometrial cancer, small cell lung, squamous cell of head and neck. |
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Definition
| Taxanes (paclitoxel and Docetoxel) |
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Term
| Inhibits Tropoisomerase II and Mitochondrial ETC |
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Definition
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Term
| Used in combo treatment for small cell carcinoma, prostate, and testicular cancer. Sides include alopecia and myelosuppression |
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Definition
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Term
| inhibits ribonucleotide reductase preventing DNA synthesis |
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Definition
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Term
| Used for sickle cell, melanoma, refractory CML |
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Definition
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Term
| Inhibits Tropoisomerase I, disrupting topographic structure of DNA |
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Definition
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Term
| Used in Lung and Ovarian, colorectal, solid tumor cancers |
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Definition
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Term
| Dual action in suppressing cell proliferation and is anti-emetic. MOPP |
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Definition
| Adrenocorticosteroids (Prednisone/Dexamthasone) |
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Term
| Sides include cushing like disease, hypertension, immunosuppression, hyperglycemia, psychosis, osteoporosis, cataracts, acne, peptic ulcer |
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Definition
| Adrenocorticosteroids (prednison/Dexamthasone) |
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Term
| Estrogen antagonist as well as partial agonist, structurally related to synthetic estrogen. Breast cancer, and homone dependent endometrial carcinoma |
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Definition
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Term
| Estrogen like effect on bone and lipid metabolism. Antagonizing estrogen on mammary tissue. Used in Osteoporosis |
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Definition
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Term
| Estradiol analogue of a PURE estrogen receptor antagonist that works by degrading the receptor |
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Definition
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Term
| Aramatase inhibitor used in metastic breast cancer |
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Definition
| Aminoglutethimide Letrozole |
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Term
| A non steroidal aromatase suppressing estradiol. A competative inhibitor |
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Definition
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Term
| Oral steroidal aromatase inhibitor used in adjuvant treatment of estrogen receptor. For breast cancer in post menopausal women |
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Definition
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Term
| Inhibits Bcr-Abl tyrosine portein kinase. Used in CML for philadelphia chromosome |
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Definition
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Term
| Selective epidermal growth factor receptor-Tyrosine kinase inhibitor |
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Definition
| Gefitinib (also Sumitinib, somfenib) |
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Term
| Inorganic metal complex that acts as a powerful alkylating agent. Solid tumors, including bladder,ovarian, testicular |
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Definition
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Term
| Causes Ototoxicity, renal toxicity, and severe vomiting |
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Definition
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Term
| MOPP regimine and is an Alkalating agent |
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Definition
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Term
| Hydrolyzes blood asparagine, thus depriving the tumor cells of asparagine required for protein synthesis |
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Definition
| L-Asparaginae/Pegaspargase |
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Term
| Used for acute childhood leukemia, spares the BM while hitting proliferating cells |
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Definition
| L-Asparaginase/Pegasparagase |
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Term
| IL-2 recombinant formulation |
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Definition
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Term
| ab against HER2 protein in combo with 1st line chemo. For breast cancer. Causes cardiomyopathy |
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Definition
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Term
| ab against CD20 on B's, used in B cell leukemia |
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Definition
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Term
| A retinoid, increases cell differentiation, decreasing proliferation. Increases like expectancy |
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Definition
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Term
| ab against VEGF or VPF, 1st line metastic colorectal, HER2 breast, small cell lung, glioblastoma, renal cell, and used in combo with iNF-alpha |
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Definition
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Term
| Alkylating agents used in Indolent NHL lymphoma |
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Definition
| chlorambucil, cyclophosphamide, bendamustine |
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Term
| Anthracyclines used in indolent NHL chemo |
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Definition
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Term
| Purine analogue used in indolent NHL chemo |
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Definition
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Term
| Chimeric antibody with anti-cd20 activity. new agent with mild toxicity. response is only 10.2 months. |
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Definition
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Term
| Radio conjugated ab administered alone to prolong remission for NHL |
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Definition
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Term
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Definition
Mustargen
Oncovin
procarazine
prednisone |
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Term
| ABVD-non alkylating regimen |
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Definition
Adriamycin
Bleomycin
Vinblastine
Dacarbazine |
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Term
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Definition
| Cyclophosphamide, carmustine, etoposide |
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Term
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Definition
| Carmustine, etoposide, cytarabine, melphalan |
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Term
| A new antibody drug conjugate showing great promise in HL and anaplastic large cell lymphoma. Combines a CD-30 antibody with a potent toxin (Auristatin) |
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Definition
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