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GIT pharmacology
Gastric ulceration, emesis, anti emesis, tx of diarrhoea and constipation, bloat and colic
16
Veterinary Medicine
Undergraduate 3
05/29/2012

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Term
H2R antagonists
Definition
-used to control acid secretion in the control of gastric ulceration
-block H2R on parietal cells, so block histamine stimulation of parietal cells and decr H+ release from parietal cell
(decr. basal and food stimulation H+ secretion)
e.g. cimetidine, ranitidine
Term
Cimitidine
Definition
-used to control acid secretion in the control of gastric ulceration
-block H2R on parietal cells, so block histamine stimulation of parietal cells and decr H+ release from parietal cell
(decr. basal and food stimulation H+ secretion)
Term
Pirenzipine
Definition
Muscarinic antagonist - blocks muscarinic R on parietal cell so block H+ secretion directly
- blocks muscarinic R on ECL cell, which decr. histamine release and so decr. stimulation of parietal cell by hist. and decr H+
Term
Proton pump inhibitors
Definition
Block H+/K+ pump of parital cell so decr. H+ secretion - accumulates in areas of low pH so can effective for 2-3 days e.g. omeprazole
Term
Antacids
Definition
Neutralising drugs used in the tx. of gastric ulcers
e.g. sodium bicarbonate, aluminium salts
Term
Sodium biacrobonate (NaHCO3-)
Definition
NaHCO3- + HCL --> NaCl+ H2CO3 --> H2O + CO2
i.e. HCl is diluted - soluble and fast acting but needs to be taken several times a day
Term
Aluminium salts
Definition
Used to neutralise the stomach in prevention / treatment of gastric ulcers.
Al. hydroxide gel + HCl --> AlCl2
i.e. HCl neutralised
Gel is also protective
Can cause constipation and so combo w. magnesium salts (s. effects diarrhoe) and can cancel out
Term
Sucralfate
Definition
protect the mucosa in gastric ulceration - a complex of sulphated sucrose and aluminium hydroxide - form complex gel w. mucus and coat the mucosa
Term
Bismuth chelate
Definition
used to protect the mucosa in gastric ulceration
-coats ulcer base
-absorbs pepsin
-enhances PG synthesis and so stimulates HCO3- secretion
-kills Helicobacter pylori
Term
Misoprostol
Definition
A PGE1 synthetic analogue - used to protect the mucosa in gastric ulceration - acts directly on paritel cells to decr. acid secretion
-maintains / incr mucosal blood supply
-incr. mucus and HCO3- secretion
-highly useful if ulcers associated w. NSAIDs
Term
Phenothiazines e.g. ACP
Definition
-anti-emetic D2R antagonist
-good at preventing vomiting caused by agents which directly stimulate the Chemical Trigger Zone
NB: also sedative
Term
Metoclopramide
Definition
-anti-emetic D2R antagonist (and 5HT3)
-good at preventing vomiting caused by agents which directly stimulate the Chemical Trigger Zone
-also peripheral cholinergic actions - promote gastric emptying by inhibiting D2R in gut which would normally inhibit motility
Term
Diphenhydramine
Definition
anti emetic w. H1R antagonist action - highlu effective against motion sickness and against stimuli acting locally in the stomach
Term
Hycosine
Definition
Anti-emetic - ACh-M antagonists - effective in motion sickness
Term
Onclansetron
Definition
Anti-emetic - 5HT3 antagonists - acts on chemical trigger zone
-extremely potent
-main effect possibly due to peripheral 5HT3 in gut
-esp. useful in cytotoxic induced vom
Term
Bethanechol
Definition
pro-kinetic drug used as anti-emetic
-stimulates M3R in gastric sm. muscle
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