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GI drugs
Pharmacology
49
Veterinary Medicine
Not Applicable
06/27/2020

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Cards

Term
types of emetics
Definition
local acting

central acting
Term
types of antiemetics
Definition
phenothiazine derivatives (chlorpromazine, acepromazine, Prochlorperazine)

antihistamine (Benadryl, dramamine, meclizine)

procainamide derivatives (metoclopramide)

anticholinergics (atropine)

serotonin receptor antagonist (ondansetron)

NK-1 receptor antagonist (cerenia)
Term
antidiarrheals
Definition
narcotics (loperimide in Imodium)

anticholinergics (Propantheline, Aminopentamide)

protectants (kaolin and pectin, activated charcoal)

adsorbents (bisthmuth)
Term
centrally acting emetics
Definition
apomorphine

xylazine (cats)
Term
locally acting emetics
Definition
hydrogen peroxide

ipecac
Term
med classes for gastric ulcers
Definition
(1) H2 receptor antagonists (famotidone), (2) proton pump inhibitors, (3) antacids, (4) gastromucosal protectants, and (5) prostaglandin E1 analogues.
Term
h2 receptor antagonists
Definition
cimetidine, ranitidine, famotidine, and nizatidine
Term
proton pump inhibitors
Definition
Omeprazole, pantoprazole,
Term
antacids
Definition
aluminum/ magnesium hydroxyzide
Term
gastromucosal protectant
Definition
sucralfate
Term
prostaglandin E1 analogs
Definition
misoprostol
Term
laxative categories
Definition
saline/hyperosmotic agents (lactulose, magnesium, phosphate)

bulking agents (psyllium)

lubricants (mineral oil, petrolatum)

stool softener (Docusate sodium)

irritants (Bisacodyl (Dulcolax) castor oil)
Term
causes of diarrhea
Definition
hypersecretion, increased permeability, osmotic overload, and altered intestinal motility. Parasitism
Term
two basic categories of GI prokinetics and stimulants
Definition
Dopaminergic antagonists and serotonergic
Term
dopaminergic antagonist
Definition
metoclopramide
Term
serotonergic prokinetics
Definition
cisapride
Term
anti-inflammatory agents for inflammatory bowel issues
Definition
prednisone, azathioprine, sulfasalazine, and olsalazine.
Term
oral product categories
Definition
Dentrifice and cleansing products
Fluoride Products
Perioceutic agents
Tissue regeneration agents
Polishing paste
Disclosing solution
Term
drug that inhibits gastrointestinal absorption of drugs, toxins, or chemicals by attracting and holding them to its surface.
Definition
adsorbent
Term
Blocking nerve impulse transmission through the parasympathetic nervous system; also called parasympatholytic. drugs may be used for the treatment of diarrhea or vomiting
Definition
anticholinergic
Term
An area in the brain that activates the vomiting center when stimulated by toxic substances in the blood.
Definition
chemoreceptor trigger zone
Term
Activated by or transmitted through acetylcholine; also called parasympathomimetic. Cholinergic drugs increase activity in the gastrointestinal tract.
Definition
cholinergic
Term
preparation for cleansing teeth that is available in a powder, paste, or liquid.
Definition
dentrifice
Term
The act of vomiting.
Definition
emesis
Term
Vomiting of blood (the vomitus often resembles coffee grounds).
Definition
hematemesis
Term
Dark or black stools that result from blood staining. Bleeding has occurred in the anterior part of the gastrointestinal tract.
Definition
melena
Term
hormone secreted by cells in the duodenal mucosa that causes contraction of intestinal smooth muscle.
Definition
motilin
Term
A cell located in the gastric mucosa that secretes hydrochloric acid
Definition
parietal cell
Term
wave of smooth muscle contraction that passes along a tubular structure (gastrointestinal or other) and moves the contents of that structure forward.
Definition
peristalsis
Term
Casting up of undigested or semidigested (ruminant) foodstuff from the esophagus or rumen.
Definition
regurgitation
Term
Periodic constriction of segments of the intestine without movement backward or forward; a mixing rather than a propulsive movement.
Definition
segmentation
Term
An area in the medulla that may be stimulated by the chemoreceptor trigger zone, the cerebrum, or peripheral receptors to induce vomiting.
Definition
vomiting center
Term
functions if the GI tract
Definition
Takes food and fluid into the body
Absorbs nutrients and fluid
Excretes waste products
Term
contains enzymes that begin the digestion of
Definition
starches
Term
Sodium bicarbonate is excreted by
Definition
pancreas
Term
names of 2 bird stomachs
Definition
proventriculus (stomach) and ventriculus (gizzard)
Term
3 functions of the colon
Definition
removes water from the material,

forms certain vitamins in hind-gut fermenters (a part of the colon in rabbits and horses)

stores waste products
Term
parasympathetic stimulation if GI tract causes
Definition
increases intestinal motility (movement), increases intestinal secretions (release of fluid), and opens sphincters (muscles that open and close bodily openings) to allow food to move through the system.
Term
sympathetic stimulation if the GI tract causes
Definition
decreases motility and secretions, and closes sphincters.
Term
emetic center is connected to what areas? Impulses from any of these areas can trigger vomiting.
Definition
chemoreceptor trigger zone (CRTZ), the cortex, the pharynx, gastrointestinal tract, urinary system, and heart.
Term
triggers for vomiting
Definition
Pain, excitement, or fear
Disturbances of the inner ear
Drugs—apomorphine, digoxin
Metabolic conditions (uremia and ketonemia (blood abnormalities], endotoxemia [sickness caused by internal toxins])
Irritation of peripheral receptors
Term
don't give emetics to animals with these conditions
Definition
Are comatose or are actively having seizures
Have depressed pharyngeal (swallowing) reflexes due to heavy sedation or otherwise
Are in shock or are dyspneic (having difficulty breathing)
Have ingested strong acids, alkali agents, or other caustic agents that will cause more damage on the way back out
Term
central and peripheral antiemetic activities of metoclopramide.
Definition
Centrally, it blocks the CRTZ and peripherally, it increases stomach contractions and emptying, and strengthens cardiac (upper stomach) sphincter tone.
Term
how antihistamines control vomiting in animals suffering from motion sickness or ear problems
Definition
antihistamines act by blocking the CRTZ impulses to the emetic center and may cause sedation in some patients.
Term
aminopentamide (Centrine), anticholinergics help with vomiting how?
Definition
block the parasympathetic innervation and result in decreased gastrointestinal spasms, movements, and secretions. The drug aminopentamide helps block the CRTZ and acts through the peripheral nervous system (the system that connects muscles, glands, and receptors to the central nervous system [brain and spinal cord]) to stop vomiting. Gastric emptying is actually slowed, so this drug may actually increase the tendency to vomit. Anticholinergics can cause dry mucous membranes and urinary retention.
Term
signs of gastric ulcers
Definition
Hematemesis (vomiting of blood)
Lack of appetite
Pain
Melena (dark, tarry stools in their bowel movements)
Term
causes of gastric ulcers
Definition
Stress
Metabolic disease
Increased stomach acid secretion
Drug therapy (steroids or NSAIDS)
Term
reacts indirectly with a large number of livermetabolized drugs, because it inhibits an enzyme found in the liver (the cytochrome p450 enzyme
Definition
cimetidine
Term
causes of diarrhea
Definition
Parasites
Hypersecretion
Increased permeability
Osmotic overload (too much movement of fluid through a semipermeable membrane)
Altered intestinal motility
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