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Final
LAst lecture- therapuetics of osteoporosis
54
Anatomy
2nd Grade
12/06/2012

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Cards

Term
impact of fractures affects?
Definition
morbidity and mortality
Term
is osteoporosis preventable?
Definition
yes!
Term
2 broad non-pharm ways to prevent osteoporosis
Definition
increase bone mass
social and diet changes
Term
when does bone mass peak?
when would be best to try to increase this mass?
Definition
25-30
early age
Term
what age is social/diet change msot important?
what are 3 points to this change?
Definition
any age
smoking cessation, only 2 drinks/day, decrease caffeine
Term
what are 2 fall prevention techniques
Definition
strength exercises
safe home env
Term
what is a surrogate marker?
Definition
BMD
Term
evidence of benefits of men comes from?
Definition
studies on women
Term
adequate_ and _ intake is absolute
Definition
vit D and calcium
Term
what dose of Ca is needed to see benefit
what is neede in combo to decrease fractures?
Definition
1000 mg
Vit D
Term
what does NOF reccomend for Ca intake?
Definition
1200 mg/day
Term
what elemental Ca has the most %?
which has the least?
Definition
Calcium carbonate
calcium gluconate
Term
insoluble/soluble Ca is favored in most?
do you take it with meals?
what pH is needed?
Definition
insoluble
no
acidic
Term
soluble/insoluble Ca is preferred in acholhydria?
Definition
soluble (doesnt need acidic pH)
Term
Calcium carbonate:
dose?
cost?
meal?
Definition
1 tab per dose
cheap
needs meals
Term
clacium citrate
dose?
cost?
meals?
Definition
2 tabs per dose
expensive
doesnt need meals
Term
which Ca is better for acholhydria or older patients?
Definition
Ca citrate
Term
_ needs to be replete prior to osteoporosis therapy?
what shows this?
Definition
Vit D
25-Oh greater than 30
Term
risk factors for Vit D deficiency-6
Definition
limited sun
malabsorption
meds
dark skin
obese
CKD
Term
NOF reccomneds Vit D intake of-
Definition
800-1000 i.u/day
Term
repletion doses for Vit D2
for D3
how long do you treat for?
Definition
ergocalciferol
cholecaliferol
8-12 weeks
Term
> _ mg of vit D or Ca wont be absorbed per meal
Definition
500
Term
what is the most common ADE of Ca or Vit D
Definition
constipation
Term
BPs approved by FDA to prevent and AND treat osteoporosis?
Definition
yes
Term
BPS shown to decrease what fractures?
which specific one decreases mortality
Definition
hip, verrtebral
zoledronic
Term
which Ca meds are insoluble
Definition
carbonate, phosphate
Term
do you not take BPs?
what do you take?
Definition
Food! low orlal bioavailability
full glass of water
Term
what intake must be adequiate to use BPs
Definition
Ca
Term
what patients should BP be avoided-2
Definition
renal decrease
GI issues
Term
rare ADEs of BPs-4
Definition
osteonecrosis of jaw
atrial fib
muscoskel pain
femur fractures
Term
what is the 1st line therapy for OP
Definition
bisphosphonates
Term
which med is approved for ppl at high risk of future fracture?
Definition
teriparatide
Term
how is teriparatide dosed and admin?
max yrs of use?
Definition
Sub Q daily
2
Term
teriparatide is best if used?
Definition
before BPs
Term
Denosumab is approved for? -4
Definition
post menopausal OP
OP in men
adrogen bone loss in men w/ prost cancer
aromatse bone loss in women w/ breat cancer
Term
what med supresses bone turnover?
Definition
denosumab
Term
what med is FDA approved for prevention of post menopausal OP?
Definition
estrogen
Term
what is the dose for estrogen?
need to utilize _ if have intact uterus
Definition
.625 or lower of CEE
progestin
Term
estrogen/ non estorgen for 1st line prevention?
Definition
non estrogen
Term
if use estrogen need to emphasize need for _
Definition
regular exams
Term
which med is a estrogen receptor modulator
Definition
raloxifene
Term
what is raloxifene approved for?
what is the dose
Definition
prevention and treatment
60 mg 1x daily
Term
what is ADE of raloxifene
Definition
hot flashes
thromboembo events (clot)
Term
if immobility is planned need to stop raloxifene _ days before
Definition
3
Term
calcitonin is admin 2 ways-
which is cheaper and better tolerated?
Definition
Subq
intranasal
intranasal
Term
_ adequate intake is needed to take calcitonin
Definition
Vit D and Ca
Term
calcitonin is primarily used in ppl with _ associated wiht OP
Definition
pain
Term
men comprise _/5 hip fracture
Definition
1
Term
do men or women have hgiher mortality with hip fracture?
Definition
men
Term
what hormone plays role in men's OP
Definition
testosterone
Term
whcih med needs perosn to be upright 30 min
Definition
risondrenate
Term
admin of denosumab?
Definition
SubQ ev 6 months
Term
what two meds arent for treatment in OP for men?
Definition
estorgen
raloxifene
Term
how often should DXA be done
-what can pay for this?
Definition
Q2 yrs
medicare
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