Term
| What is a common form of pancreatitis in dogs? |
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Definition
| Acute pancreatic necrosis, the necrosis starts at the periphery of the lobule |
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Term
| How do you diagnose pancreatatitis in dogs? |
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Definition
Clinical signs, lab findings and imaging
There isn't really a highly specific/sensitive test |
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Term
| What CBC findings do you get in canine pancreatitis? |
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Definition
| Polycythaemia, anaemia, leucocytois, lymphopaenia, eosinopaeina, monocytosis, low platlets |
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Term
| What biochem findings come with canine pancreatitis? |
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Definition
| Fasting hyperlipidemia, hyperprotienarmia, azotaemia,increased ALI and ALP, hyperglycaemis (stress, DM) |
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Term
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Definition
| MAS= maldigestion or maladorbtion |
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Term
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Definition
| Nutrients are not being digested, usualy due to exocrine pancreatic insufficency (EPI) |
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Term
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Definition
| Nutrients are digested, but cannot b absrobed by the GIT wall, due to diffuse small intestine disesae |
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Term
| What are the MAS clinical signs? |
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Definition
| diarrhoea, weight loss, steatorrhea, always hungry |
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Term
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Definition
| When 85% of the pancreas is no longer functioning. EPI is the main cause of maldigestion |
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Term
| What can cause the loss of the pancreas? |
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Definition
| Genetics, autoimmune disease, secondary to chronic pancreatitis, neoplasia |
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Term
| What is the gold standard test for EPI? |
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Definition
| Serum Trypsin Like Immunorectivity (Serum TLI) |
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Term
| What are the advantges of TLI? |
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Definition
Stable, not affected by concurrent disease
The test is currently only available for cats and dogs |
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Term
| What are some inportant considerations for the TLI test? |
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Definition
Do not run at a human lab - species specific
May be false neg with renal Dx
Requires 12hr fast
Increased TLI post dex treatment (wait 7 days) |
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Term
| What can cause malabsorbtion? |
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Definition
SI bacterial overgrowth
Lympangectasia
Villous atrophy and loss
Mucosal necrosis
Diffuse SI disease |
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Term
| What vitamins/mineral levels can be examined to localise the site of the lesion? |
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Definition
Folate and B12
Folate is abs proximal SI (jejunum), while B12 is abs in the illium |
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Term
| What would you expect to find regarding folate and B12 with an overgrowth of bacteria? |
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Definition
| The bacteria eat the B12 and produce folate, so and decrease in B12 and increase in folate |
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Term
| WHat do you see in EPI regarding folate and cobalamin (B12) |
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Definition
Same as SIBO
Increase folate
Decrease B12 |
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Term
| Are B12 and folate sensitive test for EPI and SIBO? |
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Definition
| No, these signs will be seen in any severe, diffuse SI disease |
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