Term
| the sedatives/hypnotics-4 |
|
Definition
propofol
etomidate
ketamine
fentanyl |
|
|
Term
|
Definition
depolarizing
non-depolar
spasticity control |
|
|
Term
| rapid induction of anesthesia done by- |
|
Definition
|
|
Term
|
Definition
|
|
Term
| maintenance of anesthesia done by-3 |
|
Definition
|
|
Term
| prevention of post surgicla N/V done by |
|
Definition
|
|
Term
| prevention of secretion of fluids done by |
|
Definition
|
|
Term
| the use of IV anesthetics are good for-2 |
|
Definition
procedures of short duration
induciton of inhalent anesthesia |
|
|
Term
| _ DOA is invaluable for outpatient anesthesia |
|
Definition
|
|
Term
|
Definition
|
|
Term
| combo sedatives can lead to-2 |
|
Definition
resp depression
CNS depression |
|
|
Term
|
Definition
|
|
Term
| GABA A recpt is a _ channel |
|
Definition
|
|
Term
the GABA A recpt is made of
_ alpha
_beta
_gamma |
|
Definition
|
|
Term
| BDZs bind where on the GABA |
|
Definition
| btwn alpa and beta subunit |
|
|
Term
| where do barbs bind on GABA |
|
Definition
|
|
Term
what is the most used barb?
what is its DOA |
|
Definition
thiopental
really short acting (onset 10-30 sec) |
|
|
Term
|
Definition
enhance GABA binding
prolong Cl opening
depress glutamate actions |
|
|
Term
| bc of their lipophilicity the barbs do what fast? |
|
Definition
| blood - brain distribution |
|
|
Term
|
Definition
hypotension, resp/CNS depression
decrease cerebral metab |
|
|
Term
| BDZs don't have what effect? |
|
Definition
|
|
Term
| BDZ are used for what kind of sedaiton? |
|
Definition
|
|
Term
what is the MOA of BDZs?
-specifically 3 things |
|
Definition
allosteric modulators of the GABA A recpt
increase bdining, increase Cl opening, increase Cl influx |
|
|
Term
| BDZs first go to the brain why? -2 |
|
Definition
| bc lipophillic na dhighly perfused |
|
|
Term
|
Definition
|
|
Term
|
Definition
| resp depress, hypotension |
|
|
Term
|
Definition
| competitive antagonist of GABA A |
|
|
Term
| what med antagonizes the action of BDZs can can be used for overdose? |
|
Definition
|
|
Term
| propofol is the most common what? |
|
Definition
|
|
Term
| uses for propofol in diagnostic proceudre-2 |
|
Definition
|
|
Term
| propofol can be used for induciton and maint of anesthesia when- |
|
Definition
| in- and out-pateint surgeries |
|
|
Term
| propofol can be used how in the ICU |
|
Definition
| agitation with the ventilator |
|
|
Term
what is the MOA of propofol?
can also do? |
|
Definition
potentiates the GABA A recpt action on B2 subunit
inhibit Glu NMDA recpt |
|
|
Term
|
Definition
|
|
Term
|
Definition
| hypotension, rep depress, propofol infusion syndrome |
|
|
Term
|
Definition
induction/maint of genral anesthesia
sedation |
|
|
Term
|
Definition
| allosteric modulator of GABA A recpt |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
no severe cardio/resp side effects
use with ppl with CAD, hypovolemia, cerebral vasc disease |
|
|
Term
| what is the big side effect of ketamine |
|
Definition
| dissociative anesthesia (eyes open and involuntary mvoenet, but unresponsive to commands) |
|
|
Term
|
Definition
|
|
Term
|
Definition
sedation/analgesia
induction/maint anesthesia |
|
|
Term
| use ketamine for anaesthesia for ppl at risk for-2 |
|
Definition
|
|
Term
| ketamine 2 less major ADEs |
|
Definition
|
|
Term
|
Definition
|
|
Term
post-anesthetic emergence reactions to ketamine?
these are less pronounced in? |
|
Definition
|
|
Term
|
Definition
bronchodilation
little resp depression |
|
|
Term
|
Definition
| agonist of opioid mu recpt |
|
|
Term
| what is the anesthetic adjuvant med |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what is the reversal agent for fentanyl |
|
Definition
|
|
Term
| spasmolutics are used for? |
|
Definition
|
|
Term
|
Definition
| activate nicotinic recpt for prolonged time |
|
|
Term
| non-depoalrizing NMBAs MOA |
|
Definition
| anatag ACH at nicotinic recpt |
|
|
Term
nondepolar or depolarizing agetns can be reversed?
how? |
|
Definition
|
|
Term
short acting nondepolar NMBA;
elimination |
|
Definition
|
|
Term
| intermediate acting nondepolar NMBA |
|
Definition
|
|
Term
| long acting NMBA; elimination? |
|
Definition
|
|
Term
the steroid type nondepolar NMBAs have _ DOA
they are also eliminated how? |
|
Definition
|
|
Term
| what are some steroid type NMBAs |
|
Definition
|
|
Term
|
Definition
| succinylcholine (60-90 sec onset) |
|
|
Term
| what is the short onset, short duration NMBA |
|
Definition
|
|
Term
| ADEs of succinylcholine-3 |
|
Definition
| bradycardia, muscle pain, K for prolonged depolar |
|
|
Term
| use of succinyl choline with anesthetic increase incidence of- |
|
Definition
|
|
Term
|
Definition
baclofen
tizanidine
dantrolene
diazepam/BDZs |
|
|
Term
MOA of baclofen?
-2 specific things |
|
Definition
binds to GABA b recpt
reduced glut, aspartate
inhibit mono or polysynapt spinal reflexes |
|
|
Term
|
Definition
|
|
Term
MOA of tizanidine
-this drug canbe used acute/chronic |
|
Definition
|
|
Term
|
Definition
| reduces skeletal muscle strength |
|
|
Term
| antispasm drugs act on what relxes-2 |
|
Definition
|
|
Term
| what is an antispasm agent for physical therapy |
|
Definition
|
|
Term
| ADEs of antispasm agents-2 |
|
Definition
|
|
Term
|
Definition
| prevent ACh release leading to paralysis of muscles |
|
|
Term
|
Definition
| 3 months of flaccid paralysis |
|
|
Term
| botilism is approved for-3 |
|
Definition
muscle disorder of eye
cosmetic procedures
chronic spasticity |
|
|
Term
|
Definition
| influenza like symtpoms, gallbladder infeciton |
|
|
Term
| look on slide 37 for overview of lecture! |
|
Definition
|
|
