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Exam 2
Hypothyroidism
26
Veterinary Medicine
Professional
10/14/2016

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Cards

Term
Where is thyroglobulin stored?
Definition
-follicles
Term
How does Thyroxing (T4) become Triiodothyronine (T3) in hte thyroid?
Definition
-doiodonation
Term
Is T3 or T4 usually bound to protein?
Definition
-T3
Term
Does T3 or T4 have more biologic activity?
Definition
-Fre T3
Term
What do thyroid hormones do?
Definition
-fetal development
-calorigenesis
-protein & enzyme synthesis
-carb and lipid metabolism
-chronotropic and ionotropic effects
-erythropoiesis
Term
What is a tertieary thyroid hormone issue? Is it common or rare?
Definition
-hypothalamus
-very rare
Term
What is a secondary thyroid hormone issue? Is it common or rare?
Definition
-pituitary
-rare
Term
What is a primary thyroid hormone issue? Is it common or rare?
Definition
-thyroid gland
-common
Term
What is the typical signalment of a hypothyroid dog?
Definition
-mean age 7y
-no sex predilaection
-pure breeds
-Breeds: Dobies, Goldens
Term
What are the clinical signs of hypothyroidism?
Definition
-lethargy
-unwillingness to exercise
-mental dullness
-weight gain
-sold intolerance aka heat-seeking
-repro issues
-bacterial infections
Term
What are the neuro signs of hypothyroidism?
Definition
-peripheral neuropathy
-CNS sign may be multifocal
-CN deficits: peripheral vestibular disease, facial nerve paralysis
-central vestibular dz
-cerebral dz: seizures, disorientation, circling
Term
What are the other clinical signs associated with hypothyroidism?
Definition
-laryngeal paralysis
-megaesophagus
-myasthenia gravis
Term
Are derm signs common with hypothyroidsim?
Definition
-up to 80%
Term
What are the derm signs seen with hypothyroidism?
Definition
-bilateral truncal alopecia (non-pruritic_
-poor hair regrowth
-dry scaly skin
-hyperpigmentation
-comedones
-bruising
-poor wound haling
-bacterial pyoderma
Term
What do we see on physical exam with hypothyroidism?
Definition
-all the clinical signs
-hypothermia
-bradycardia
-myxedema
Term
What do we see on a CBC with hypothyroidism?
Definition
-non-regen anemia
-platelet count is normal
-WBC variable
Term
What do we see on biochem panel of hypothyroidism?
Definition
-hypercholinesterasterolemia
-hypertriglyceridemia
-inc ALP >> ALT
Term
Can we diagnose hypothyroidism based on low TT4?
Definition
-no any illnes can cause low TT4
Term
How do we diagnose hypothyroidism?
Definition
-total T4
-free T4
-TSH
Term
Which drugs are known for causing false hypothyroidism?
Definition
-glucocorticoids
-phenobarbital
-sulfonamides
-carprofen
-aspirin
Term
In addition to hormone levels, how do you diagnose hypothyroidsim?
Definition
-TRH or TSH stimulation
-thyroid US
-thyroid biopsy
Term
What are anti-thyroglobulin Ab indicative of? Is it diagnotic for hypothyroidism?
Definition
-thyroiditis
-NO
Term
What is the treatment of choice for canine hypothyroidism?
Definition
-Levothyroxine
Term
How do we monitor Levothyroxine?
Definition
-TT4 should be upper half of RI or slightly above RI
Term
With proper treatment,when should the signs of hypothyroidism resolve?
Definition
-inc activity: 1-2 weeks
-weight loss: 8 week
-normal hair coat: several months
-neuro deficits: variable
Term
If Levothyroxine treatment fails for hypothyroidism, what do we do? What is our major concern?
Definition
-T3 (liothyronine) supllementation
-overtreatment much more likely as compared with T4 supplementation
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