Term
| Where is thyroglobulin stored? |
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Definition
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Term
| How does Thyroxing (T4) become Triiodothyronine (T3) in hte thyroid? |
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Definition
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Term
| Is T3 or T4 usually bound to protein? |
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Definition
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Term
| Does T3 or T4 have more biologic activity? |
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Definition
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Term
| What do thyroid hormones do? |
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Definition
-fetal development
-calorigenesis
-protein & enzyme synthesis
-carb and lipid metabolism
-chronotropic and ionotropic effects
-erythropoiesis |
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Term
| What is a tertieary thyroid hormone issue? Is it common or rare? |
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Definition
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Term
| What is a secondary thyroid hormone issue? Is it common or rare? |
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Definition
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Term
| What is a primary thyroid hormone issue? Is it common or rare? |
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Definition
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Term
| What is the typical signalment of a hypothyroid dog? |
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Definition
-mean age 7y
-no sex predilaection
-pure breeds
-Breeds: Dobies, Goldens |
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Term
| What are the clinical signs of hypothyroidism? |
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Definition
-lethargy
-unwillingness to exercise
-mental dullness
-weight gain
-sold intolerance aka heat-seeking
-repro issues
-bacterial infections |
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Term
| What are the neuro signs of hypothyroidism? |
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Definition
-peripheral neuropathy
-CNS sign may be multifocal
-CN deficits: peripheral vestibular disease, facial nerve paralysis
-central vestibular dz
-cerebral dz: seizures, disorientation, circling |
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Term
| What are the other clinical signs associated with hypothyroidism? |
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Definition
-laryngeal paralysis
-megaesophagus
-myasthenia gravis |
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Term
| Are derm signs common with hypothyroidsim? |
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Definition
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Term
| What are the derm signs seen with hypothyroidism? |
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Definition
-bilateral truncal alopecia (non-pruritic_
-poor hair regrowth
-dry scaly skin
-hyperpigmentation
-comedones
-bruising
-poor wound haling
-bacterial pyoderma |
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Term
| What do we see on physical exam with hypothyroidism? |
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Definition
-all the clinical signs
-hypothermia
-bradycardia
-myxedema |
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Term
| What do we see on a CBC with hypothyroidism? |
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Definition
-non-regen anemia
-platelet count is normal
-WBC variable |
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Term
| What do we see on biochem panel of hypothyroidism? |
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Definition
-hypercholinesterasterolemia
-hypertriglyceridemia
-inc ALP >> ALT |
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Term
| Can we diagnose hypothyroidism based on low TT4? |
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Definition
| -no any illnes can cause low TT4 |
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Term
| How do we diagnose hypothyroidism? |
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Definition
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Term
| Which drugs are known for causing false hypothyroidism? |
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Definition
-glucocorticoids
-phenobarbital
-sulfonamides
-carprofen
-aspirin |
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Term
| In addition to hormone levels, how do you diagnose hypothyroidsim? |
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Definition
-TRH or TSH stimulation
-thyroid US
-thyroid biopsy |
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Term
| What are anti-thyroglobulin Ab indicative of? Is it diagnotic for hypothyroidism? |
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Definition
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Term
| What is the treatment of choice for canine hypothyroidism? |
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Definition
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Term
| How do we monitor Levothyroxine? |
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Definition
| -TT4 should be upper half of RI or slightly above RI |
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Term
| With proper treatment,when should the signs of hypothyroidism resolve? |
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Definition
-inc activity: 1-2 weeks
-weight loss: 8 week
-normal hair coat: several months
-neuro deficits: variable |
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Term
| If Levothyroxine treatment fails for hypothyroidism, what do we do? What is our major concern? |
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Definition
-T3 (liothyronine) supllementation
-overtreatment much more likely as compared with T4 supplementation |
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