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Exam 1
Glomerular Dz
25
Veterinary Medicine
Professional
02/09/2017

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Cards

Term
What is the common familial glomerulopathies in dogs?
Definition
=Canine Juvenile Hereditary Nephropathy: FAmilial Renal Dz
Term
What is the major immune-mediated glomerulonephritis?
Definition
-immun-complex GN
Term
What is suppurative glomerulitis (aka embolic nephritis)?
Definition
-acute septicemia dz w/ bacteria in glomeruli & interstitial capillaries
-abcesses can occur
Term
What is the most common form of embolic nepritis/suppurative glomerulitis?
Definition
-Actinobacillosi in neonatal foals: A. equuli
Term
Which animals are affected by actinobacillosis septicemia?
Definition
-neonatal foals
Term
What are Protein-losing nephropathies?
Definition
-protenuria => leaky glomeruli => amyloidosis or glomerulonephritits
Term
What is nephrotic syndrome?
Definition
-protein-losing nephropathies that are characterized by high protein in urine, low body albumin levels, high cholesterol levels, high triglyceride levels, sub! edema dn hydrothroax/peritoneum
Term
What is anti-BM glomerulonephritis?
Definition
-autoimmune dz w/ Ab directly againt BM of glomerulie
-complement activated
-glomerulonephritis
Term
What is immune-complex glomerulonephritis? Caused by?
Definition
-soluble circ immune complexes deposited in glomerular BM inciting somplement fixation and inflamatory response
=chronic infectious dz causing persistent antigenemia
Term
What are the most comon immunoglobulins involved in immune-complex glomerulonephritis?
Definition
-IgM and IgG
Term
What causes immune-med glomerulonephritis in horses?
Definition
-Strep
-EIA
Term
What causes immune-med glomerulonephritis in cattle?
Definition
-BVDV
-Trypanososma
Term
What causes immune-med glomerulonephritis in cats?
Definition
-FIV
-FeLV
Term
What causes immune-med glomerulonephritis in pigs?
Definition
-hog cholera
-african swine fever
Term
What causes immune-med glomerulonephritis in sheep?-
Definition
-hereditary hypocomplementemia in Finnish Landrace lambs
Term
What does acute GN look like on necropsy?
Definition
-capsular surface slightly graular
-glomeruli visible as red to gray pin dots on cut surface (this is normal in a hrose)
Term
What are the three microscopic forms of GN?
Definition
-proliferative CH: inc # of cells in glomeruli
-membranous GN: thickened glomerular BM
-membranoproliferative GN: inc cellularity & thick BM
Term
What does GN looklike on IHC?
Definition
-flouresces bright green due to deposition of immunoglobulins
Term
What is chronic GN?
Definition
-fibrosis of glomeruli
-secondary to loss of other components of nephrons, hypertension, or DM
Term
What does chronic GN look like?
Definition
-grossly: finely granular scarred kidneys
-microscopicallly: uniformly shrunken, hypocellular, inc type I collagen, capillaries collapsed and dec
-aka obsolecent
Term
What causes nodular glomerulosclerosis? What does it look like?
Definition
-DM
-nodular thickened areas of mesangial matrix
Term
What is amyloid? What is amyloidosis?
Definition
-insoluble fibrillar glycoprotein
-depositied in glomeruli normally gut can ge deposited inmedullary interstitium
Term
Which animals are predisposed to amyloidosis?
Definition
-Shar-Pei dogs
-Beagles
-Siamese cats
-Abyssinian cats
Term
What does amyloidosis look like?
Definition
-Grossly: enlarged, pale granular kidneys w/ pinpoint tan dots in cortex
Term
How do we diagnose amyloidosis on necropsy?
Definition
-stain deep purple w/ Lugol's sln
-Microscopically, stain w/ Congo red and amyloid will be orange
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