Term
| What is the common familial glomerulopathies in dogs? |
|
Definition
| =Canine Juvenile Hereditary Nephropathy: FAmilial Renal Dz |
|
|
Term
| What is the major immune-mediated glomerulonephritis? |
|
Definition
|
|
Term
| What is suppurative glomerulitis (aka embolic nephritis)? |
|
Definition
-acute septicemia dz w/ bacteria in glomeruli & interstitial capillaries
-abcesses can occur |
|
|
Term
| What is the most common form of embolic nepritis/suppurative glomerulitis? |
|
Definition
| -Actinobacillosi in neonatal foals: A. equuli |
|
|
Term
| Which animals are affected by actinobacillosis septicemia? |
|
Definition
|
|
Term
| What are Protein-losing nephropathies? |
|
Definition
| -protenuria => leaky glomeruli => amyloidosis or glomerulonephritits |
|
|
Term
| What is nephrotic syndrome? |
|
Definition
| -protein-losing nephropathies that are characterized by high protein in urine, low body albumin levels, high cholesterol levels, high triglyceride levels, sub! edema dn hydrothroax/peritoneum |
|
|
Term
| What is anti-BM glomerulonephritis? |
|
Definition
-autoimmune dz w/ Ab directly againt BM of glomerulie
-complement activated
-glomerulonephritis |
|
|
Term
| What is immune-complex glomerulonephritis? Caused by? |
|
Definition
-soluble circ immune complexes deposited in glomerular BM inciting somplement fixation and inflamatory response
=chronic infectious dz causing persistent antigenemia |
|
|
Term
| What are the most comon immunoglobulins involved in immune-complex glomerulonephritis? |
|
Definition
|
|
Term
| What causes immune-med glomerulonephritis in horses? |
|
Definition
|
|
Term
| What causes immune-med glomerulonephritis in cattle? |
|
Definition
|
|
Term
| What causes immune-med glomerulonephritis in cats? |
|
Definition
|
|
Term
| What causes immune-med glomerulonephritis in pigs? |
|
Definition
-hog cholera
-african swine fever |
|
|
Term
| What causes immune-med glomerulonephritis in sheep?- |
|
Definition
| -hereditary hypocomplementemia in Finnish Landrace lambs |
|
|
Term
| What does acute GN look like on necropsy? |
|
Definition
-capsular surface slightly graular
-glomeruli visible as red to gray pin dots on cut surface (this is normal in a hrose) |
|
|
Term
| What are the three microscopic forms of GN? |
|
Definition
-proliferative CH: inc # of cells in glomeruli
-membranous GN: thickened glomerular BM
-membranoproliferative GN: inc cellularity & thick BM |
|
|
Term
| What does GN looklike on IHC? |
|
Definition
| -flouresces bright green due to deposition of immunoglobulins |
|
|
Term
|
Definition
-fibrosis of glomeruli
-secondary to loss of other components of nephrons, hypertension, or DM |
|
|
Term
| What does chronic GN look like? |
|
Definition
-grossly: finely granular scarred kidneys
-microscopicallly: uniformly shrunken, hypocellular, inc type I collagen, capillaries collapsed and dec
-aka obsolecent |
|
|
Term
| What causes nodular glomerulosclerosis? What does it look like? |
|
Definition
-DM
-nodular thickened areas of mesangial matrix |
|
|
Term
| What is amyloid? What is amyloidosis? |
|
Definition
-insoluble fibrillar glycoprotein
-depositied in glomeruli normally gut can ge deposited inmedullary interstitium |
|
|
Term
| Which animals are predisposed to amyloidosis? |
|
Definition
-Shar-Pei dogs
-Beagles
-Siamese cats
-Abyssinian cats |
|
|
Term
| What does amyloidosis look like? |
|
Definition
| -Grossly: enlarged, pale granular kidneys w/ pinpoint tan dots in cortex |
|
|
Term
| How do we diagnose amyloidosis on necropsy? |
|
Definition
-stain deep purple w/ Lugol's sln
-Microscopically, stain w/ Congo red and amyloid will be orange |
|
|
