Term
| What are the selection criteria of antimicrobials for treating BRD? |
|
Definition
-cost
-cnvenience
-appropriateness |
|
|
Term
|
Definition
| -administration of antimicrovial to cattle deemed high risk for BRD based upon group characteristics, not individual diagnosis |
|
|
Term
| True or False: Metaphylaxis is the same as prophylaxis. |
|
Definition
|
|
Term
| Which type of drugs are the standard for BRD treatment? |
|
Definition
|
|
Term
| What are the general considerations for Abx use? |
|
Definition
-don't stack 'cidal and 'static
-limited combinations have true synergism: synergism requires different targets of action
-antimicrobials ASSIST the immune system: allow abx andimmune system to work |
|
|
Term
| How long should I wait to administer another medication? |
|
Definition
| -respect the interval: read the label and at most cut 2 days off label duration |
|
|
Term
| Can we use Ceftiofur off label? MOA? |
|
Definition
-ELDU prohibited but can use for other indications
-MOA: inh cell wal synthesis |
|
|
Term
| Can we use Fluoroquinolones off label? |
|
Definition
|
|
Term
| Why do we always use the high dose of ENrofoxicin (Baytril) for treating BRD? MOA? |
|
Definition
-try to stay above mutant prevention concentration
-MOA: inh DNA gyrase |
|
|
Term
| Is Florfenicol (Nuflor) bacteriocidal or bacteriostatic? MOA? |
|
Definition
-bacteriostatic
-binds to 50S ribosomal subunit to inh bacterial protein synth |
|
|
Term
| True or False: If resistance shows when treating BRD w/ Macrolides, just switch Macrolide. |
|
Definition
| -FALSE, switch drug class |
|
|
Term
| What is the MOA of Erythromycin? Do we use it to treat BRD? |
|
Definition
-inh 50S ribosome
-not really |
|
|
Term
| Which BRD bugs have shown resistance? |
|
Definition
| -M. haem, H. somni, and less commonly P. mult |
|
|
Term
| Which drugs has there been documented resistance in the treatment of BRD? |
|
Definition
| -everything except ceftiofur |
|
|
Term
| What are some factors that contribute to resistance in threatment of BRD? |
|
Definition
-cutting the dose: terrible
-underestimating weight
-inappropriate duration of therapy
-indiscriminant use of the drug |
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