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Exam 1
Lecture 12 part 1- growth factors
42
Anatomy
4th Grade
01/27/2014

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Term
supportive care is defined as maximizing?
there is no specific?
Definition
quality of life
regimen
Term
the two big targets in supportive care is-2
Definition
myelosuppression
N/V
Term
chemo drugs affects rapid dividing cells where-3
Definition
tumor
bone marrow
muscal linig in mouth, GI, etc
Term
complicaitons of chemo-
Definition
anemia
neutropenia
mucositis/stomatitis
Term
look at slide 6 and 7 for overview of hematopoesis
Definition
Term
anemia in men def
in women
Definition
<14 hgb
<12 hgb
Term
grade/toxicity of anemia:
hgb>11
Definition
0/none
Term
grade/toxicity of anemia:
hgb 10ish
Definition
1/mild
Term
grade/toxicity of anemia:
hgb 8-10
Definition
2/moderate
Term
grade/toxicity of anemia:
6.5-7.9
Definition
3/severe
Term
grade/toxicity of anemia:
hbg <6.5
Definition
4/life threatening
Term
what 3 cancers result in the most Hgb loss-
Definition
leukemia
lymphoma
Gyn
Term
causes of anemia-4
Definition
chronic
chemo
mineral def
disease related
Term
effects from anemia-3
Definition
decrease QOL
increase trnasfusion
decrease survival
Term
what chemo predispooses for anemia-2
Definition
platimun meds
combo therapyies
Term
predisposing factors for anemia besides chemo-4
Definition
radiation
chronic renal fail
myelodyplastic
comorbidities: ex- cancer
Term
chemo agnets/combos with omst Grade 3-4 anemias-4
Definition
docetaxel
VIP
cisplatin-etoposide
CHOP
Term
chemo agnets wiht the most Grade1-2 anemias
Definition
paclitexal-dox; paclit-carbo
docetaxel
Term
tx for anemia-4
Definition
trnasfusion
ESA
non ESAs
supplements
Term
beenfit of trnasfusion for anemia-1
Definition
quick enhancement. get 1 dL increase in 1 hr
Term
cons of doing trnasfsuion for anemia-5
Definition
graft vs host
allergy
infections
replase
worse prognossi
Term
use of _ has decrease the use of trnasfusion in anemic cancer pts
Definition
ESAs
Term
MOa of ESA (erythopoietin)
Definition
stimulates red bone marrow->more EPO->RBCs
Term
types of ERAs:
rHuEPOs-3
Definition
epoetin a,b,delta
darpoetin alpha
CERA
Term
longest half life agnet rHuEPO:
Definition
CERA (135 hrs)
Term
leas half life EPOs-
Definition
epoetin beta - 4 hrs
Term
erythoptein vs darpoetin:
which has more chains?
more half life?
Definition
darbopoetin
darbopoetin
Term
Epoetin alpha dosing and admin
150 U-
40,000
10,000
Definition
3 times weekly, Iv/SC
q week IV/SQ
3 times weekly IV/SQ
Term
administraitn for darbopetin
Definition
SQ
Term
dosing frq for dabopoetin
500
300q
200
2.5 mcg/kg
Definition
Q 3wks
Q 3 wks
Q2 wks
Q wk
Term
the biggest event of using EPOs/ERAs is
Definition
thombotic events!
Term
overtime which results in higher hgb- trnasfusion or EPO?
Definition
EPO
Term
safety of ESA/EPOs- increased _ and decreased_
Definition
thombolytic events
overall survival
Term
HR for mortality greater in ESA or non ESA cancer tx?
Definition
ESA tx
Term
* ESA tx in cancer pts decreased survival, if taking chemo it was less pronounced but cant rule it out!
Definition
Term
EPO effects tumor bc there are recpt on the tumor surface** (so increase prolif of cance cell, and metastais of tumor)
Definition
Term
pts can use ESA when-
Definition
chronic kid disease, CKD from T2DM
temporary in chemo-oinduced for solid canc. stop when chemo ends
HIV induced
undergoing replacment surgery
hep, SLe, chron's
Term
NEVER use ESAs when?
Definition
cancer is CURABLE
Term
dont use ESAs in what type of cancers
Definition
hematological bc these ppl are already rpone to anemia
Term
ESAs shouldnt relaly be used for cnacer induced anemia either*
Definition
Term
goal of ESA tx is to-
Definition
reduce trnasfusions
Term
give ESA to certain chemo pts when Hgb< _ and goal is hgb<
Definition
10
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