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Exam 1
Lecture 1- Intro
61
Anatomy
4th Grade
01/26/2014

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Term
is this cell cycel specifc or non specifc:
antimetabolites (methotrexate)
Definition
CCS
Term
is this cell cycle specifc or non specifc:
antibitoics (belomycin)
Definition
CCS
Term
is this cell cycle specifc or non specifc:
txanae (paclitaxel)
Definition
CCS
Term
is this cell cycle specifc or non specifc:
epipodophys
Definition
CCS
Term
is this cell cycle specifc or non specifc:
vinca alkaloids
Definition
is this cell cycle specifc or non specifc:
Term
Cell cycle specifc drugs wokr mainly on what cells
Definition
dividing cells
Term
cell cycle specific drugs work best on what cancers-2
Definition
solid tumors
hematologic
Term
is this cell cycle specifc or non specifc:
alkylating agents
Definition
CCNS (non)
Term
is this cell cycle specifc or non specifc:
anticancer antibitoics
Definition
CCNS
Term
is this cell cycle specifc or non specifc:
camptothecins
Definition
CCNS
Term
is this cell cycle specifc or non specifc:
metals
Definition
CCNS
Term
cell cycle non specific drugs work on what cells?
Definition
dividng AND resting
Term
which drugs work on BOTH high or low growth factor?
which is only for high?
Definition
CCNS
CCS
Term
* CCS only wokr on some cell cycle phases, they are?
Definition
S, G2/M`
Term
what are the 3 targets of anti cancer drugs
Definition
proteins, DNA, RNA
Term
what are cells that are normally fast dividing?-4
*anticancer drugs can attack these too*
Definition
bone marrow, hair follicle,s gut epitheial, sperm forming
Term
Chemo drugs are more potent to high or low growth fraciton?
Definition
high
Term
why are proliferating cells more sensitive to chemo drugs?
Definition
these drugs disprutp mitotis or DNA synth
Term
slide 40 has all the toxicites chemo cna cause ot the body
Definition
Term
damage to what by anticancer drugs is the main cause of marrow toxicity
Definition
hematopoetic stem cell
Term
slide 42 has all the drug resistance pathways
Definition
Term
cancer is a loss of
Definition
growth regulation
Term
*diff genes must be altered in diff tissue to get cancer.
APC=colon for ex.
Definition
Term
tumor supporessor genes code for-
Definition
cell cylce
Term
oncogenes code for
Definition
prloferation
Term
* benging resemble orginal cells and don't recur after surgeyry
Definition
Term
* malignant cancers:
-leukemia, lympha, blastoma,
Definition
Term
what type of malignant cancer makes up 90%
what is its origin
Definition
carncinoma
epithelil (skin, organ, glands)
Term
whcih malignnant cancer is of connective tissue?
Definition
sarcoma
Term
what is the leading cause of deaht in both male aand female pts with cancer?
Definition
lung cancer
Term
poor/well differentiated cancers are more drug resist
why?
Definition
poor differentiated
genetic mutation made it too diff of morphology
Term
Gompertzian growth curve shows that cancer is _ growth
Definition
log
Term
at what size is cancer detectable on gompterzian scale
Definition
1 gm/ 10^9/ 30 doubling
Term
the gompterzian scale shows that with time _ increases and _ decreases
Definition
doubling time
growth fraction
Term
tumor growth fraciton is:
Definition
prloferating: resting cells
Term
tissue in G0 has what kind of growth fraction?
Definition
low
Term
doubling time for a soldi tumor?
(double time is time for tumor to double in size)
Definition
2-3 mo
Term
doubling time for breast cancer
for lymph/leuk
Definition
100 days
1 day
Term
*doubling times diff in subcategoires of specific cancers *look at alide 17
Definition
Term
methods for cancer to spread (metastasis)-4
Definition
lymp, blodd, CSF, local
Term
after removing rpimary tumor, where does recurring cancer normally go?
Definition
distant site. ex: leukemia
Term
metastaic pattern varies with tumor*
Definition
Term
what are common sites fo metastasis-7
Definition
liver, lung, lymph, bone, brain, skin, adrenal
Term
T0 means
T1-3 means?
T4 menas
Definition
carcnimoa insitu
larger size
spread to another organ
Term
N in staging of cancer means?
Definition
spread extenet to lymph nodes
Term
what does an X mean if given in staging of cancer?
Definition
not evaulable
Term
Duke's grading scale is for what cancer?
Definition
colon
Term
Gleason grading scale is for what cancer
Definition
prostate
Term
Epsteien Barr virus causes what cnacers-2
Definition
nasopharyngeal
Burkitt's lymphoma
Term
2 viruses that can cause cancer
Definition
T cell
Hep B and C
Term
Chemo has _ log kill and _ regrowth
Definition
3
1
Term
factros that influence survival rate?-3
Definition
nature of cancer
pt
pharmacology
Term
what terminology only applies to leukemia?
Definition
consolidation
induction
Term
Def:
induce remission in leukemia
Definition
induction therapy
Term
Def:
given after remission to maintain leukemia remission
Definition
consolditation
Term
def :
GIVEN BEFORE PRIMARY THERAPY TO ASSIST (INTENT TO SHRINK CANCEr)
Definition
neoadjuvent
Term
def:
lowest point for hematopoeitc cells
Definition
nadir
Term
majority of cancer chemof ro currative or pallatative pruposes?
Definition
pallatative
Term
is chemo used more on its own or with other meds
Definition
with tohers/combinaiton
Term
what 3 cancers does chemo not work for
Definition
malignant myleoma
pancreatic cancer
renal cancer
Term
what stage is cell division
Definition
M
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