Term
| Of CRH, ACTH and ADH, which use Gs and which use Gq linked receptors? |
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Definition
ADH - Gq (IP3/DAG)
CRH & ACTH - Gs (cAMP) |
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Term
| What limits the rate of steroid hormone production? |
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Definition
| delivery of cholesterol to the mitochondria |
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Term
| What happens to cholesterol once it is delivered to the mitochondria? |
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Definition
1. StAR protein on OUTER membrane and PBR protein on INNER membrane bring cholesterol into the inner mitochondria.
2. P450 side chain enzyme on the INNER mitochondrial membrane converts cholesterol to pregnenolone |
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Term
| What promotes StAR activity? |
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Definition
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Term
| What type of steroid hormone is cortisol? |
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Definition
|
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Term
| Mineralcorticoids are produced by the... |
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Definition
|
|
Term
| Glucocorticoids are produced by the... |
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Definition
|
|
Term
| DHEA/androstenedione are produced by the... |
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Definition
|
|
Term
| Catecholamines are produced by the... |
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Definition
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Term
True or False
The conversion of pregnenolone to progesterone does not take place in the mitochondria |
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Definition
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|
Term
True or False
The conversion of progesterone to deoxycorticosterone or deoxycortisol takes place in the mitochondria |
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Definition
|
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Term
| All steroid hormones are carried around attached to transport proteins except... |
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Definition
| mineralcorticoids e.g. aldosterone |
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Term
|
Definition
promotes gluconeogenesis from fat and protein
regulates inflammatory response
inhibits chemocytokine attraction |
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Term
| What is addison's disease? |
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Definition
| Adrenal cortex does not respond to ACTH (glucocorticoids & mineralcorticoids are not produced) |
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|
Term
| What is congenital drenal hypoplasia? |
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Definition
| impaired secretion of all adrenal steroids |
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Term
| With addison's disease, will you see hyper or hypocglycemia? |
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Definition
| hypo (cortisol not being produced) |
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Term
| Why do you see skin bronzing in patients with Addison's disease? |
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Definition
| ACTH is being produced in high amounts, because the body is trying to stimulate the zona fasiculata to produce cortisol. ACTH also promotes melanin production, which causes the bronzing |
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