Term
| What type of cells in the anterior pituitary produce GH? |
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Definition
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Term
| The ______ nucleus of the hypothalamus produces GHRH which targets somatotropes of the ant pit to release ______. |
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Definition
paraventricular
growth hormone |
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Term
| What hormone family does GH belong to? What type of receptor does it use? |
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Definition
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Term
| What type of receptor does IGF-1 use? |
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Definition
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Term
| What effect does IGF-1 have on GH? |
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Definition
| inhibitory effect on its release from the anterior pituitary (negative feedback) |
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Term
True or False
GH is the most abundant pituitary hormone |
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Definition
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Term
| What is the role of IGF-2? |
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Definition
| important during embryonic/fetal growth |
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Term
| When does GH secretion reach a max? |
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Definition
daily: 1 hour after sleep
lifetime: during pre-pubertal growth spurt |
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Term
| How is GH transported in the blood? IGF-1? |
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Definition
GH: can be free in blood, but mostly bound to carrier protein
IGF-1: bong to transport proteins |
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Term
| Hypoglycemia will (increase/decrease) GH secretion |
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Definition
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Term
| High dietary protein will (increase/decrease) GH secretion |
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Definition
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Term
| Hyperglycemia will (increase/decrease) GH secretion |
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Definition
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Term
| Glucocorticoids will (increase/decrease) GH secretion |
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Definition
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Term
| Exercise will (increase/decrease) GH secretion |
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Definition
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Term
| How do GH & IGF-2 work together during fetal/neonatal growth? |
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Definition
GH promotes growth of cartilage
IGF-2 promotes ossification of cartilage |
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Term
| Which hormone promotes lipolysis, GH or IGF-1? |
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Definition
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Term
| Which hormone increases insulin sensitivity, GH or IGF-1 |
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Definition
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Term
| Which hormone increases blood concentration of glucose, GH or IGF-1? |
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Definition
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Term
| Which hormone promotes protein synthesis & amino acid uptake, GH or IGF-1? |
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Definition
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Term
| Under production of (or reduced sensitivity to) GH in adults will lead to... |
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Definition
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Term
| What is the correlation between cushing's and alopecia? |
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Definition
| cushing's syndrome = high cortisol = inhibits GH production |
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Term
| What causes pygmies / laron-type dwarfism? |
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Definition
| reduced sensitivity to GH & IGF in young animals/people |
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Term
| What is the difference between gigantism & acromegaly? |
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Definition
Gigantism = hypersecretion of GH before puberty
Acromegaly = hypersecretion of GH in adults |
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