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        | Ventricular tachycardia has __ complex QRS. |  | Definition 
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        | Supraventricular tachycardia has __ complex QRS. |  | Definition 
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        | Non-drug option for treatment of Supraventricular Tachycardia (SVT): |  | Definition 
 
        | Vagal maneuvers: hold breath, valsalva maneuver Carotid massage
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        | SVT treatment options when vagal maneuveres do not work: |  | Definition 
 
        | - Short term control: 6 mg IV Adenosine - Calcium Channel Blockers: Verapmil, Diltiazem
 - Beta Blokcers (slower than CCBs): Esmolol, Metroprolol Tartrate
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        | With the treatment of Atrial fibrillation and atrial flutter, the goal is to control ___ __ and prevent __ __. |  | Definition 
 
        | - ventricular rate - emoblic complications
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        | Treatment options for Atrial Flutter and Atrial Fibrillation: |  | Definition 
 
        | - Calcium channel blockers - Digoxin
 - Amiodarone
 
 may have to use electrical cardioversion to restore sinus rhythm
 - Beta blockers
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        | Wide complex tachycardia, aka __ __, in a stable patient should be treated with __ ___, __, or ___. __ should be used in patients with heart failure or structural heart disease. |  | Definition 
 
        | - Ventricular tachycardia (b/c wide complex) - IV procainamide, propafenone, or flecainide
 - Amiodarone
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        | Unstable wide complex VT should be treated with: |  | Definition 
 
        | - Adenosine- to test be careful though - Immediate cardioversion
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        | Common presenting symptoms of paroxysmal supraventricular tachycardia from most common to least common: |  | Definition 
 
        | 1. Palpitations 2. Dizziness
 3. Shortness of Breath
 4. Syncope
 5. Chest pain
 6. Fatigue
 7 Diaphoresis
 8. Nausea
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        | - heart rate greater than 100 bpm - p waves similar to sinus rhythm
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        | Sinus Node Reentrant Tachycardia: |  | Definition 
 
        | - p waves similar to sinus rhythm - abrupt onset and offset
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        | - Heart rate 120-250 bpm - P wave morphology different than sinus rhythm
 - Long RP interval
 - Tachycardia not terminated by AV block
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        | Multifocal Atrial Tachycardia on EKG: |  | Definition 
 
        | - Heart rate 100-200 bpm - 3 or more different P wave morphologies
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        | - Heart rate 200-300 bpm - AV conduction 2:1 or 4:1
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        | Atrial Fibrillation on EKG: |  | Definition 
 
        | - irregularly irregular rhythm - lack of discernable P waves
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        | AV Nodal Reentrant Tachycardia: |  | Definition 
 
        | - Heart rate 150-200 bpm - P wave either within the QRS or shortly after
 - Short RP interval in typical AVNRT, long RP interval in atypcial AVNRT
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        | AV Reentrant Tachycardia on EKG: |  | Definition 
 
        | - Heart rate 150-250 bpm - Narrow QRS in orthodromic conduction
 - Wide QRS in antidromic conduction
 - Dx excluded by AV block during SVT
 - P wave after QRS
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        | How do you exclude dx of AV Reentrant Tachycardia: |  | Definition 
 
        | - if there is an AV block during SVT then it is not AV reentrant tachycardia |  | 
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        | List the different types of Supraventricular Tachycardias (SVTs): |  | Definition 
 
        | - Sinus tachycardia - Inappropriate sinus tachycardia
 - Sinus node reentrant tachycardia
 - Atrial Tachycardia
 - Multifocal Atrial Tachycardia
 - Atrial Flutter
 - Atrial Fibrillation
 - AV Nodal Reentrant Tachycardia
 - AV Reentrant Tachycardia
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        | Paroxysmal SVT can lead to: |  | Definition 
 
        | - Heart Failure - Pulmonary Edema
 - Myocardial Ischemia
 - Myocardial Infarction
 
 Chronic SVT can cause cardiomyopathy
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        | - target end organ damage - systolic > 220 OR
 - diastolic > 125
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        | - greater than 180/110 - symptoms are NOT progressive and there is not end organ damage
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        | Malignant hypertension is usually associated with __ __ and is characterized by ___ and ___ due to __ in ___. |  | Definition 
 
        | - renal disease - hemolysis and thrombocytopenia
 - necrosis in arterioles
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        | End Organ Damage due to HTNsive emergency, from most common to least common: |  | Definition 
 
        | 1. Cerebral Infarction 2. Hypertensive Encephalopathy
 3. Acute Heart Failure Syndrome
 4. Acute Coronary Syndrome
 5. Intracerebral/Subdural Bleed
 6. Aortic Dissection
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        | Under normal circumstances, with an increase in blood pressure, the cerebral arterioles __ and cerebral blood flow stays the same. But during HTNsive emergencies, the elevated BP overwhelms autoregulation causing ___ leakage across capillaries and continued arteriole damage. This leads to __, the sine qua non of malignant HTN. The end result is __ __. |  | Definition 
 
        | - constrict - transudate
 - PAPILLEDMA- sin quo non
 - hypertensive encephalopathy
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        | Signs of HTNsive encephalopathy: |  | Definition 
 
        | - Headaches - Irritability
 - Confusion
 - Somnolence
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        | With HTNsive emergencies the heart is experiencing an increased ___ which leads to increased oxygen demand and __, this eventually can cause __ __, __ __, or __. |  | Definition 
 
        | - workload - ischemia
 - pulmonary edema
 - myocardial ischmia
 - myocardial infarction
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        | With HTNsive emergencies the renal system undergoes ___ and __ __, and an overall impairment of the autoregulation. this can manifest itself as: |  | Definition 
 
        | - arteriosclerosis and fibrinoid necrosis - worsening renal function
 - hematuria
 - RBC cast formation
 - proteinuria
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        | - Papilledema (optic disc swelling) - Cotton whool spots
 - Hemorrhages
 - Macular star
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        | - more common in African Americans - males at greater risk for HTNsive emergencies than females
 - most commonly in middle aged (40s-50s)
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        | Explain Cushing's Reflex: |  | Definition 
 
        | brain hemorrhage> space occupying lesion in the brain> pushes against the brain> decreased blood flow to the brain> ischemia to the brain tells body that brain isn't getting enough blood> increased pressure> increased bleeding etc. etc. |  | 
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        | Work-up in pt with HTNsive emergency: |  | Definition 
 
        | - CBC - Chemistry
 - UA
 - Pregnancy test
 - CXR, Head CT, Chest CT, aortic angiogram
 - EKG, cardiac enzymes
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        | In a HTNsive emergency, the blood pressure should be lowerd by __ of the mean arterial pressure. |  | Definition 
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        | 2 main classes of drugs to lower blood pressure in the ER; |  | Definition 
 
        | - Vasodilators - Anti-Adrenergic Agents
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        | 4 vasodilators that are good to use in ER to lower bp with HTNsive emergencies: |  | Definition 
 
        | - Nitroprusside - Nicardipine
 - Enalapril
 - Fenoldopam
 
 (Don't use nitroglycerin or hydralizine in these cases b/c bp will drop too rapidly)
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        | Nitroprusside is a vasodilator that can be given in HTNsive emergencies. Give the dosage, onset, and adverse effects: |  | Definition 
 
        | Dosage: 0.25-10mcg/kg/min Instant onset 1-2 minutes
 Adverse effects: cyanide poisoning
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        | Nicardipine is a vasodilator that can be used in HTNsive emergencies. Give the dosage, onset, and adverse effects: |  | Definition 
 
        | Dosage: 5-15 mg/hr Onset/duration: 5-10 min/1-4 hours
 Side effects: Tachycardia, flushing
 AVOID WITH HEART FAILURE
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        | Enalapril is an ACE-I vasodilator used in HTNsive emergencies. Dosage, onset/duration, side effects: |  | Definition 
 
        | dosage: 10-40 mg IM, 1.25-5 mgIVq6hours onset: 20-30 min/6 hours
 SE: hypotension, renal failure, hyperkalemia
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        | Fenoldopam is a ___ ___ vasodilator used in HTNsive emergencies. Dosage, onset/duration, side effects: |  | Definition 
 
        | - dopamine 1 agonist - dosage: 0.1-0.3 mcg/kg/min
 - onset/duation: 20-30 min/6 hours
 - SE: flushing, headache, tachycardia
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        | Name 3 adrenergic antagonists that can be used with HTNsive emergencies: |  | Definition 
 
        | - Labetalol (alpha1, beta 1 and 2 blocker), some sympathomimetic effect - Esmolol- beta-1 selective blocker
 - Phentolamine- alpha 1 blocker
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        | Adverse effects of Labetalol: |  | Definition 
 
        | - heart block - orthostatic hypotension
 - avoid in heart failure and asthma
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        | - hypotension - avoid with heart failure and asthma
 
 
 very short acting
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        | - tachycardia - flushing
 - headache
 
 can use this one in asthma b/c only block alpha 1 receptors, no effect on beta receptors
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        | Oral drugs that can be used in HTNsive emergencies: |  | Definition 
 
        | - Captopril- ACE-I - Clonidine- central acting alpha 2 agonist
 - Labetalol
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        | hypotension in high renin states 
 benefit: very short acting
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        | - dry mouth - sedation
 - bradycardia
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        | - heart failure - heart block
 - bronchospasm
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        | How to rapidly reduce bp with acute myocardial ischemia? |  | Definition 
 
        | - IV nitroglycerin, beta blockers, ACE-inhibitors |  | 
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        | How to rapidly reduce bp in pt with CHF with pumonary edema: |  | Definition 
 
        | - IV nitroglycerin, furosemide, morphine |  | 
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        | How to rapidly reduce bp in acute aortic dissection: |  | Definition 
 
        | - IV nitroprusside + beta blocker OR
 - IV trimethaphan + beta blocker
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        | How to rapidly decrease bp with hypertensive encephalopathy or SA hemorrhage: |  | Definition 
 
        | - IV  nitroprusside, labetalol or nimodipine |  | 
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        | How to rapidly reduce bp with MAO tyramine interactions with acute HTN: |  | Definition 
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