Shared Flashcard Set

Details

Drugs
Osteoporosis
10
Anatomy
Graduate
01/10/2015

Additional Anatomy Flashcards

 


 

Cards

Term
Estrogen
Definition

MOA-suppresses cytokines that stimulate osteoclasts and induces expression of Fas ligand in osteoblasts to stimulate osteoclast apoptosis

 

MAF-breast cancer, stroke, CV disease

 

Not used anymore, used for menopause symptoms

Term
Raloxifene
Definition

2nd/3rd line of defense

MAE-VTE

Only helps prevent fractures at vertebral level

Antiresorptive

Term
Calcitonin
Definition

2nd/3rd line of defense

Only prevents fractures at vertebral level, but used for pain of acute vertebral fractures

MAE-rhinitis

Use for postmenopausal osteoporosis treatment

Intranasal/IM injection

Term
Denosumab
Definition

1st line of defense

Prevents vertebral, nonvertebral and hip fractures

Use when patients have renal issues***

MAE: ONJ, AFF, skin reactions

Antiresorptive

Term
Teriparatide
Definition

Anabolic, expensive

Only use with severe osteoporosis

MOA-stimulates both osteoblast and osteoclast activity but when given once a day in short doses it enhances osteoblast activity more

MAE: osteosarcoma

Term
Bisphosphonates
Definition

Antiresorptive, 1st line defense

Prevents vertebral, nonvertebral and hip fractures

MOA-high affinity for bone mineral which helps them to be absorbed by osteoclasts and paralyze the cell, also inhibits farnesyl pyrophosphate synthase to prevent osteoclasts from maturing

MAE-ONJ, AFF, esophageal irritation, should not be used in patients with kidney disease

Poorly absorbed when taken orally

Term
Alendronate
Definition

Bisphosphonate

Have generic form

Given orally (daily or weekly)

Term
Ibandronate
Definition

Bisphosphonate, 1st line drug

Have generic form

Given orally or IV

Term
Risedronate
Definition

Bisphosphonate

Given orally

Term
Zoledronic acid
Definition

Bisphosphonate

IV dosing

Most potent for inhibiting FPPS and has highest affinity for bone

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