Loss of islet of Langerhans cells in pancreas 

Insulin resistance of cells

Type 1 - beta cells are not producing - dog

Type 2 - body cells are resistance - cat 

PU/PD

CBC, U/A

Control hyperglycemia, weight loss, insulin

Congenital or aquired 

Central - lack of ADH

Nephrogenic - lack of response to ADH

PU/PD

U/A, CBC, ADH response test

Replace ADH

Cushings disease 

Pituitary Dependent (PDH) 80%

Adrenal 20%

PU/PD, weakness, increased panting

CBC, chemistries, ACTH stimulation test, low dose and high dose dexamethasone 

Decrease cortisol formation

Addisons disease 

PU/PD, weakness, anorexia

Hyperkalemia, hypoatremia, Na:K, ACTH stimulation test

Overactive 

Excessive T3 abd T4 production 

Weight loss with polyphagia, tachycardia, increased BP

Nuclear scintigraphy

Decrease thyroid hormone production 

Thyroid atrophy 

Lethargy, weakness, weight gain, intolerance to cold 

CBC, chemistries, TSH test 

Thyroid stimulation