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Complement System Quiz
N/A
40
Anatomy
Undergraduate 2
04/09/2009

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Term
The complement system is made up of how many globulins (Plasma proteins)?
Definition
30+
Term
Where are globulins of the Complement System synthesized?
Definition
in the liver
Term
Where are globulins of the Complement System always present in an active state?
Definition
in plasma
Term
What activates globulins of the Complement System?
Definition
the presence of a pathogen
Term
What mechanism is similar to the Complement System and why?
Definition
Blood Clotting Mechanism because it happens in steps.
Term
What are the three routes of activation of the Complement System?
Definition
1. Classic Pathway
2. Alternative Pathway
3. Lectin Pathway
Term
Any substance that illicits an immune reaction
Definition
Antigen
Term
This is present most of the time on the surface of cells
Definition
Antigen
Term
What do Pathogens contain that illicit a response?
Definition
Foreign Antigens
Term
what produces an antibody to join with Foreign Antigens
Definition
B-Cells (B- Lymphocytes)
Term
Antibodies joined with Antigens make?
Definition
Antigen Antibody Complex
Term
This attracts complement to bind to it and begin a chemical cascade
Definition
Antigen Antibody Complex
Term
What acts as a neon sign that says "Foreigner here!" so that Complements will know where to bind?
Definition
Antigens (Ours not foreign)
Term
Antigen + Antibody + Complements =?
Definition
Complement Fixation
Term
what causes the chemical activation of the complement
Definition
Complement Fixation
Term
The Classic Pathway is what type of Defense
Definition
Specific Defense
Term
Antibodies have what kind of targets?
Definition
Specific Targets
Term
Anytime an Antibody is present it is what type of Defense?
Definition
Specific Defense
Term
C3 is part of what pathway?
Definition
Alternative Pathway
Term
An Antibody is part of what pathway?
Definition
Classic Pathway
Term
C3 breaks into smaller fragments that bind directly to?
Definition
ANY pathogen
Term
What is the result of all three pathways?
Definition
Chemical Cascade
Term
The Alternative Pathway is what type of method?
Definition
Nonspecific
Term
These are plasma proteins that tend to bind to carbohydrates but also bind to the surface of pathogens and cause a chemical cascade
Definition
Lectins
Term
What are the four methods that Activated Complements use to destroy pathogens
Definition
1. Inflammation
2. Immune Clearance
3. Phagocytosis
4. Cytolysis
Term
Which is the only method that activated complment uses to destroy pathogens that is a DIRECT Method?
Definition
Cytolysis
Term
Inflammation
Definition
Compliment stimulates Basophils and Mast Cells to release Histamine and other inflammatory chemicals. Complement activates and attracts Neutrophils and Macrophages because they will eat the pathogen.
Term
during imglammation, why does complement activate and attract Neutrophils and Macrophages to the area?
Definition
so that they will eat the pathogen
Term
In inflammation, what does complement stimulate to release histamind and other inflammatory chemicals?
Definition
Basophils and Mast Cells
Term
Immune Clearance
Definition
Complement causes antigen antibody complexes to attach to RBC's. As RBC's go thru the liver and spleen, macrophages remove and destroy the pathogens leaving the RBC's unharmed.
Term
During Immune CLearance, what does complement cause antigen antibody complexes to attach to?
Definition
RBC's
Term
During Immune Clearance, RBC's with antigen antibody complex attached, travel thu what organs?
Definition
Live and Spleen
Term
During Immune Clearance, what removes the pathogen in the liver and spleen?
Definition
Macrophages
Term
Phagocytosis
Definition
Neutrophils and Macrophages perform this. The complement promotes phagocutosis by a process called opsonization which caots the pathogen making them easier to phagocytize.
Term
the process of placing an outer coating on a pathogen for easier phagocytizing
Definition
Opsonization
Term
what performs Phagocytosis?
Definition
Neutrophils and Macrophages
Term
Complement promotes phagocytosis by what process?
Definition
Opsonization
Term
Cytolysis
Definition
Splitting/Breaking of cells. A group of complement proteins form a ring called a membrane attack complex (MAC). THis MAC attaches to the membrane of the pathogen and punches a hole to cause the cell to rupture.
Term
In Cytolysis, A group of complement proteins form a ring called?
Definition
a Membrane Attack Complex (MAC)
Term
What does a MAC do to a pathogen in Cytolysis?
Definition
Attaches to the membrane of the pathogen and punches a hole in it causing the cell to rupture.
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