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Clinical Lab 2
White Blood Cell Count and Differential
33
Veterinary Medicine
Not Applicable
11/20/2012

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Cards

Term
Hemacytometer
Definition
Used with whole anticoagulated blood to determine a WBC count, now used for sperm ct.
Term
Corrected WBC count
Definition
NRBC x (100/[nRBC + 100])
Term
What 3 cells can a Myeloblast turn into?
Definition
Basophil, Eosinophil, Neutrophil
Term
Which cells are the result of the division of the Myeloid Stem cell?
Definition
Basophil, Eosinophil, Neutrophil (Band), Monocyte, Platelets (Megakarocyte), Erythrocyte
Term
Band Neutrophils in circulation
Definition
Normal to see 5 or less
Term
Left Shift
Definition
Seeing more than 5 Band Neutrophils in circulation
Term
What is the most common cause of a Left Shift?
Definition
Inflammation
Term
Hypersegmented Neutrophils in circulation
Definition
more than 5 lobes
Term
Why would you see Hypersegmented Neutrophils in circulation?
Definition
Old blood
Term
What are the WBC normals for Canines?
Definition
6.0-17.0 x 10^3/mm^3
Term
What are the WBC normals for Felines?
Definition
5.5-19.5 x 10^3/mm^3
Term
Which WBC is the first line of defense?
Definition
Neutrophils
Term
What is pus?
Definition
An accumulation of dead Neutrophils and Macrophages (monocytes in tissue)
Term
What are some conditions that may lead to a Left Shift?
Definition
Hemolytic anemia, dz.s of marrow
Term
Neutrophils are know as what in these animals: Birds, Reptiles, Amphibians, Rabbits
Definition
Heterophils
Term
Toxic changes are caused by what?
Definition
Shortened maturation time in bone marrow, severe infx, acute inflammation
Term
What are some characteristics of Neutrophil toxic changes?
Definition
Larger than normal, look swollen and bloated, basophilic cytoplasm, chromatin is less dense, has doehle bodies, vacuoles, frothy (lace-like) cytoplasm
Term
What do Doehle bodies look like?
Definition
Bruise on the cell
Term
What is a Right Shift?
Definition
Increase of Hypersegmented Neutrophils
Term
What can cause a Right Shift?
Definition
Anemia, iron deficiency, liver dz, uremia
Term
Neutropenia
Definition
withhold of neutrophils in the bone marrow
Term
What causes Neutropenia?
Definition
Maybe cancer, chemotherapy, steriods, monocytes engulfing neutrophils (immune mediated)
Term
Eosinophils are considered the body's natural what?
Definition
Antihistamine
Term
Why would you see Eosinophils?
Definition
Allergic reaction, Parasitism
Term
Eosinophilia causes
Definition
Parasites, Allergies, Myositis, Panosteitis (growing pains), Addison's Dz
Term
Basophil causes
Definition
acute allergic response (anaphylaxis), parasitic infx
Term
Canine Basophils
Definition
Nucleus looks like a folded ribbon, dark purple. Granuals stain blue-black with grey-blue cytoplasm
Term
Decreased Basophils are normal in which 2 animals?
Definition
Cows, horses
Term
Where are T-cells (Lymphocyte) produced?
Definition
Thymus
Term
Where are B-cells (Lymphocyte) produced?
Definition
Bone marrow
Term
When can reactive lymphocytes be seen?
Definition
Recently vaccinated young animals
Term
Lymphocytosis causes
Definition
Fear, excitement, Chronic conditions, Leukemias, Lymphosarcoma
Term
Lymphopenia causes
Definition
Steriods, Immunodeficiency dz.s (ex. FIV), Loss of Lyphatic tissue, Impaired lymphopoesis
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