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Circulatory System
Brief overview of the circulatory and lymphatic system
61
Anatomy
Undergraduate 3
04/25/2012

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Term
plasma
Definition
55% of blood, composed of about 92% water
Term
red blood cells
Definition
erythrocytes: biconcave disks that transmit oxygen
Term
hemoglobin
Definition
protein produced with iron that assists in oxygen transport
Term
anemia:
Definition
any disorder that affects ability to transmit oxygen
Term
white blood cells
Definition
leukocytes: less than 1% of blood. major defense cells, protect body from infection
Term
neutrophils
Definition
a granulocyte (white blood cell with granules in cytoplasm) that eats bacteria and produces substances to kill bacteria. 60-70% of white blood cells.
Term
eosinophils
Definition
a granulocyte (white blood cell with granules in cytoplasm) that destroys parasites and eats allergens. 2-4% of white blood cells.
Term
basophils
Definition
a granulocyte (white blood cell with granules in cytoplasm) that triggers the inflammatory response, which increases blood flow to wound, slows clotting, and helps fight infections. <1% of white blood cells.
Term
monocyte
Definition
a large agranulocyte (white blood cell without granules in cytoplasm) which develops into a macrophage, the white blood cells that eat and digest anything that shouldn't be there. 3-8% of white blood cells.
Term
lymphocyte
Definition
an agranulocyte (white blood cell without granules in cytoplasm) that secretes antibodies and triggers the immune response. 25-33% of white blood cells. includes T cells, B cells and NK cells.
Term
platelets
Definition
aid in blood clotting
Term
pulmonary circuit
Definition
right atrium (from vena cava), right AV valve (tricuspid valve), right ventricle, pulmonary (semilunar) valve, pulmonary arteries, lungs, pulmonary veins, left atrium, left AV valve (mitral valve), left ventricle (then to systemic circuit through aortic valve)
Term
systemic circuit
Definition
(from left ventricle, through aortic (semilunar) valve), aorta, elastic (conducting) arteries, muscular (distributing) arteries, arterioles, capillaries, venules, veins (one-way valves), superior or inferior vena cava (to the right atrium)
Term
epicardium
Definition
also the visceral pericardium. surface of the heart, directly outside of the myocardium
Term
myocardium
Definition
muscular portion of the heart
Term
endocardium
Definition
thin lining of the inside of the heart
Term
coronary sinus
Definition
large vein that collects oxygen-poor blood from the myocardium of the heart and delivers it to the right atrium
Term
fossa ovalis
Definition
thin sheet that forms between right & left atria after a fetus is born (to cover the foramen ovale)
Term
papillary muscles
Definition
muscles that attach to cups of the AV vales via the chordae tendinae to prevent inversion or prolapse of the valves.
Term
chordae tendinae
Definition
cord-like tendons that connect the papillary muscles to the AV valves.
Term
sinoatrial node
Definition
impulse-generating tissue located in the right atrium of the heart
Term
cardiac muscle tissue
Definition
muscle that is striated, uninuclear, and have intercalated discs
Term
intercalated discs
Definition
identifying feature of cardiac muscle. connections between cardiac muscle cells (cardiomyocytes) that include desmosomes and gap junctions.
Term
autonomic control
Definition
parasympathetic innervation of the heart is controlled by the vagus nerve, which connects with the sinoatrial node to slow heart rate. signals for the parasympathetic control come from the medulla oblongata.
Term
fetal circulation
Definition
placenta, umbilical vein, inferior vena cava OR (liver > portal vein), right atrium, foramen ovale, left atrium, left ventricle, aorta, body
Term
tunica externa (adventitia)
Definition
exterior layer of blood vessel, made of mostly collagen and supported by external elastic lamina.
Term
tunica media
Definition
middle layer of blood vessel, made of smooth muscle and elastic tissue.
Term
tunica intima (inerna)
Definition
fine, elastic inner layer of blood vessel, composed of a single layer of endothelial cells
Term
elastic (conducting) arteries
Definition
large arteries made of collagen and elastin, including the pulmonary arteries and the aorta and its branches. the elasticity helps maintain blood pressure.
Term
muscular (distributing) arteries
Definition
smaller arteries that draw from elastic arteries. made up of layers of smooth muscle, with clearly defined internal elastic lamina
Term
arterioles
Definition
smallest arteries that connect the larger vessels to capillaries. made of smooth muscle, they are the primary source of vascular resistance, which reduces pressure for gas and nutrient exchange
Term
capillary beds
Definition
interweaving networks of capillaries that supplies an organ with blood
Term
continuous capillaries
Definition
a type of capillary that have an uninterrupted lining, allowing for only small molecules like water and ions to diffuse. found in skeletal muscle, skin, and the central nervous system
Term
capillaries
Definition
smallest type of blood vessel that enables exchange of oxygen and nutrients
Term
fenestrated capillaries
Definition
type of capillary that has pores in the endothelial lining that allows molecules and protein to diffuse. found in endocrine glands, intestines, pancreas, glomeruli of kidneys
Term
sinusoid capillaries
Definition
type of capillary that has the largest pores which allow red and white blood cells and proteins to diffuse. found in bone marrow, lymph nodes, and adrenal glands
Term
venules
Definition
smallest type of vein, which returns blood from capillary beds. has thinner walls than arterioles, and are extremely porous.
Term
veins
Definition
vessels that carry oxygen-poor blood back to the heart, and employ one-way valves and the skeletal muscle pump to keep bloodflow moving towards the heart.
Term
ascending aorta`
Definition
section of aorta between the heart and the aortic arch
Term
aortic arch
Definition
peak of the aorta shaped like an inverted u.
Term
descending aorta
Definition
splits into the thoracic aorta (above diaphragm) and abdominal aorta (below diaphragm).
Term
hepatic portal vein
Definition
blood vessel in abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver.
Term
lymph vessel
Definition
thin walled, valved structure that carries lymph.
Term
lymph fluid
Definition
plasma and other materials that are drained from the tissues by lymph vessels
Term
lymph node
Definition
a small organ that is packed with lymphocytes and macrophages, and act as filters or traps for foreign particles.
Term
tonsils
Definition
first line of defense against ingested foreign particles.
Term
spleen
Definition
an organ that acts primarily as a blood filter, removing old red blood cells and holding a reserve of RBC and lymphocytes while also recycling iron.
Term
thymus
Definition
a specialized organ of the lymphatic system that matures and "educates" T cells
Term
bone marrow
Definition
the flexible tissue inside of bones that produces new blood cells, including red blood cells, platelets, and white blood cells (especially lymphocytes).
Term
nonspecific immunity
Definition
the body's first line of defense, including skin and macrophages
Term
antigen
Definition
a substance that evokes the production of antibodies.
Term
cytotoxic T cells
Definition
T cells that directly attack other cells carrying foreign or abnormal molecules via antigen presentation.
Term
helper T cells
Definition
cells that assist other white blood cells, including activation and maturation of B cells
Term
suppressor T cells
Definition
cells that suppress the immune response when all antigens have been killed.
Term
memory T cells
Definition
antigen-specific (pre-programmed) cells that are activated by lymphocytes. sometimes called antigen-experienced because of previos encounters with their specific antigen.
Term
antibodies
Definition
large y-shaped protein produced by B cells used to identify and neutralize foreign objects.
Term
plasma B cells
Definition
large cells that are activated by helper T cells and produce and secrete large amounts of antibodies.
Term
memory B cells
Definition
formed from activated B cells, these cells are long-living cells that stick around in case of a later exposure.
Term
NK cells
Definition
cells similar to cytotoxic T cells, but allow for faster immune response due to an ability to recognized stressed cells in the absence of antibodies.
Term
humoral immunity
Definition
immunity mediated by secretion of antibodies produced by B cells
Term
cell mediated immunity
Definition
immunity involving activation of macrophages, NK cells, and cytotoxic T cells
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