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Chapter 4
A&P Saladin
49
Anatomy
Undergraduate 1
09/01/2011

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Term
Growth Factor
Definition
A chemical messenger that stimulates mitosis and differentiation of target cells that have the receptors for it; important in such processes as fetal development, tissue maintenance and repair, and hemopoieses; sometimes a contributing factor in cancer.
Term
Codominant
Definition
A condition in which neither of the two alleles, is dominant over the other, and both are phenotypically expressed when both are present in an individual. For example, When blood type alleles IA and IB are produce blood type AB when inherited together.
Term
Genome
Definition
All the genes of one individual, estimated at 100,000 genes in humans.
Term
Germ Cell
Definition
A gamete or any precursor cell destined to become a gamete.
Term
Genotype
Definition
The pair of alleles possessed by an individual at one gene locus on a pair of homologous chromosomes; Strongly influences the individual's phenotype for a given trait.
Term
Germ layer
Definition
Any of the three original tissue layers of an embryo; ectoderm, mesoderm,or endoderm.
Term
Nucleotide
Definition
An organic molecule composed of a nitrogenous base, a monosaccharide, and a phosphate group; the monomer of a nucleic acid.
Term
Host Cell
Definition
Any cell belong to the human body, as opposed to foreign cells introduced to it by such causes as infections and tissue transplants.
Term
Dominant
Definition
Pertaining to a genetic allele that is phenotypically expressed in the presence of any other allele.
Term
Law
Definition
a verbal or mathematical description of a predictable natural phenomenon or of the relationships between variables; for example, Poiseuille's Law and the 2nd Law of Thermodynamics
Term
Chromosome
Definition
A condensed form of Chromatin visible in a cell undergoing Mitosis or Meiosis.
Term
Ribonucleic Acid
Definition
Any of three types of nucleotide polymers smaller than DNA that play various rolls in protein synthesis. Composed of Ribose, Phosphate, Adenine, Uracil, Cytosine, and Guanine forming a single nucleotide chain.
Term
Autosome
Definition
Any chromosome except the sex chromosomes. Genes on the autosomes are inherited without regard to the sex of the individual.
Term
Nitrogenous Base
Definition
An organic molecule with a single or double carbon-nitrogen ring that forms one of the building blocks of ATP, other nucleotides, and nucleic acids; the basis of genetic code.
Term
Haploid
Definition
In humans, having 23 unpaired chromosomes instead of the usual 46 chromosomes in homologous pairs; in any organism or cell, having half the normal diploid number of chromosomes for that species.
Term
Somatic
Definition
pertaining to the body as a whole.
Term
Thymine
Definition
A single-ringed nitrogenous base (Pyrimidine) found in DNA, complementary to Adenine in the double helix of DNA
Term
Homozygous
Definition
Having identical alleles at the same gene locus of two homologous chromosomes.
Term
Transcription
Definition
the process of enzymatically reading the nucleotide sequence of a gene and syntheszing a pre-mRNA molecule with a complementary sequence.
Term
Nuclear Envelope
Definition
A pair of unit membranes enclosing the nucleus of a cell, with prominent pores allowing traffic of molecules between the nucleoplasm and cytoplasm.
Term
codon
Definition
a series of three nucleotides in mRNA that codes for one amino acid in a protein or signals the end of a gene
Term
Heterozygous
Definition
Having on identical alleles at the same gene locus of two homologous chromosomes
Term
Carcinogen
Definition
an agent capable of causing cancer, including certain chemicals, viruses, and ionizing radiation.
Term
Translation
Definition
The process of enzymatically reading an mRNA molecule and synthesizing the protein encoded in its nucleotide sequence.
Term
Uracil
Definition
A single-ringed nitrogenous base (pyrimadine) found in RNA; one of the 4 bases of the genetic code; in RNA occupies the place of Thymine does in DNA.
Term
Interphase
Definition
That part of the cell cycle between one mitotic phase and the next, from the end of cytokinesis to the beginning of the next prophase.
Term
Leader Sequence
Definition
A chain of hydrophobic amino acids that guides a newly synthesized protein into the cisterna of the rough endoplasmic reticulum and is then cleaved off. In the synthesis of peptide hormones, removal of the leader sequence converts the preprohormone into the prohormone
Term
Adenine
Definition
A Double-Ringed nitrogenous base (Purine) found in such molecules as DNA, RNA, and ATP; one of the 4 bases of the genetic code; complementary to thymine in the double helix of DNA
Term
Chromatin
Definition
Filamentous nuclear material composed of DNA and associated proteins.
Term
Gene Locus
Definition
The site on a chromosome where a given gene is located.
Term
Metastasis
Definition
The spread of cancer cells from the original tumor to a new location, where they seed the development of a new tumor.
Term
Daughter Cells
Definition
Cells that arise from a parent cell by mitosis or meiosis
Term
Gene
Definition
A segment of DNA that codes for the synthesis of one protein.
Term
Base Triplet
Definition
A sequence of three DNA nucleotides that codes indirectly (through mRNA) for one amino acid of a protein.
Term
Cytokinesis
Definition
Division of the cytoplasm of a cell into two cells following nuclear division.
Term
Cytosine
Definition
A single-ringed nitrogenous base (pyrimidine) found in DNA; one of the four bases of the genetic code; complementary to guanine in the double helix of DNA
Term
Apoptosis
Definition
Programmed cell death; the normal death of cells that have completed their function. Compare Necrosis.
Term
Guanine
Definition
A double-ringed nitrogenous base (Purine) found in DNA and RNA; one of the 4 bases of the genetic code; complementary to cytosine in the double helix of DNA.
Term
Genetic Engineering
Definition
Any of several techniques that alter the genetic constitution of a cell or organism, including recombinant DNA technology and gene substitution therapy.
Term
Mitosis
Definition
A form of cell division in which a cell divides once and produces two genetically identical daughter cells; sometimes used to refer only to the division of the genetic material or nucleus and not to include cytokinesis, the subsequent division of the cytoplasm
Term
mutation
Definition
any change in the structure of a chromosome or a DNA molecule, often resulting in a change of organismal structure or function
Term
Recombinant DNA
Definition
A molecule composed of the DNA of two different species spliced together, such as a combination of bacterial and human DNA used to produce transgenic bacterial that synthesize human proteins.
Term
Allele
Definition
Any of the alternative forms that one gene can take, such as dominant and recessive alleles.
Term
Chromatid
Definition
One of two genetically identical rodlike bodies of a metaphase chromosome, joined to its sister chromatid at the centromere.
Term
Mendelian Genetics
Definition
study of parents and offspring in order to distinguish and predict familial patterns
Term
Cytogenetics
Definition
using cytology and microscopy to study chromosomes and their relationship to hereditary traits
Term
Genomic Medicine
Definition
study of the DNA of whole individuals to understand health and disease.
Term
Histone
Definition
DNA wraps around a cluster of proteins called a histone (1 histone=8 proteins) about 1 ½ times like a ribbon around a spool
Term
nucleosome
Definition
These histone beads, or core particles, together with a linker DNA
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