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| Pilgrims flee to Holland to avoid religious persecution in England |
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| Virginia begins to export Tabacco |
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| The first persons of African descent arrive in Virginia: first representative assembly in English North America meets in Jamestown |
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| Pilgrims arrive at Cape Cod on the Mayflower and establish Plymouth Colony |
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| Opechancanough's Indians fail an attempt to massacre all English settlers in Virginia |
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| English Crown takes control of Virginia: the Dutch begin to settle New York and name their colony New Netherland |
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| Puritans establish Massachusetts Bay Colony |
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| Maryland becomes the first proprietary colony |
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| Leader in Massachusetts Bay Colony banish Roger Williams |
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| Harvard College is founded; first permanent English settlements established in Connecticut and Rhode Island |
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| Anne Hutchinson is convicted of heresy in Massachusetts and flees to Rhode Island |
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| Legal status of African Americans in the Chesapeake Bay region deteriorates |
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| Second attempted Native American massacre of Virgina colonist fail |
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| Powhatan's Confederacy accepts English rule |
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| Massachusetts Bay Coly adopts the first public school law in the colonies |
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| Maryland's Act of Toleration affirms religious freedom for Christians in the colony, Charles I of England is behaded |
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| Charles II is restored to the English Throne |
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| English conquer New Netherland and rename the colony New York |
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| King Philip's (Metacomet's) War inflicts heavy casualties on New Englanders |
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| William Penn founds Pennsylcania as a "holy experiment" in which diverse groups of people can live together harmoniously |
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| Glorious Revolution drives James II from England |
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| Georgia is founded as a haven for debtors and a buffer colony against Spanish Florida |
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| Stano slave uprising occurs in South Carolina |
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