Term
| First stage of stromal tissue healing? |
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Definition
| fibrous/serous effusion, fibrin forms a scaffold for cell mgiration |
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Term
| How far along in wound healing would you expect to see fibroblasts & blood vessels invading the wound? |
|
Definition
|
|
Term
| What key feature of tissue healing occurs around day 6? |
|
Definition
| collagen secretion by fibroblasts (formation of granulation tissue) |
|
|
Term
| What chemical mediators secreted by macrophages and platelets promote angiogenesis? |
|
Definition
|
|
Term
| What chemical mediators secreted by macrophages & platelets promote fibroblast infiltration & collagen secretion? |
|
Definition
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|
Term
| The proliferative phase of wound healing typically ends ___ days post-injury |
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Definition
|
|
Term
| What is involve with wound remodelling & contraction? |
|
Definition
collagen maturation (Type III -> Type I)
cross-linking of collagen bundles (increases strength)
wound contraction |
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Term
| What are the requirements for epithelial tissue to be able to repair? |
|
Definition
-mitotically active epithelium
-CT framework intact
-vascular supply |
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Term
| Which chemical mediator tends to cause less scarring TGF-beta or PDGF? |
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Definition
|
|
Term
| The first component of the ECM secreted by fibroblasts after arrival to an injury site |
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Definition
|
|
Term
| What is the role of proteases during would healing? |
|
Definition
| they remove the initin fibrin scaffold |
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Term
| Wound contraction is mediated by... |
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Definition
|
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Term
| Sutured wounds heal by ____ intention |
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Definition
|
|
Term
| What are osteoprogenitor cells? |
|
Definition
| pluripotent cells that migrate from the periosteum and endosteum, to differentited into fibroblasts/osteoblasts/chondroblasts depending on location |
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Term
| Osteoprogenitor cells in well-vascularized regions (e.g. medullary cavity) will form..... |
|
Definition
| osteoid (will mineralize to form bone) |
|
|
Term
| Osteoprogenitor cells in poorly-vascularized regions will form..... |
|
Definition
|
|
Term
| In bone, the equivalent to granulation tissue is called... |
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Definition
|
|
Term
|
Definition
|
|
Term
| What effect do corticosteroids have on wound healing? |
|
Definition
| delays healing bc reduces macrophage function, impairs fibroblast production of collagen |
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Term
|
Definition
| wound countraction in areas where skin is attached to underlying tissues |
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Term
|
Definition
| Constrition of the lumen of a tubular organ, resulting from contraction during tissue repair |
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Term
|
Definition
| when fibrous tissue forms between two organs |
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