Term
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Definition
MOA: inhibition of Na/K/2Cl symporter (loop diuretic)
Ind: CHF (organ system edema)
Drugs: aminoglycosides increase oto & nephrotoxicity, NSAIDS dec efficacy
Effects: polyuria, ototoxicity, nephrotoxicity, hypokalemia, pre-renal azotemia, sulfa-like hypersensitivity
Monitor: azotemia, BP, potassium |
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Term
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Definition
MOA: ACE inhibitor, blocks conversion of ATI to ATII, dec ATII and aldosterone effects (RAAS inhibition)
Ind: CHF, SHT, PLnephropathy, anti-myocardial remodeling
Drugs: BFF w/ lasix
Effects: RAAS inhibition, azotemia, hyperkalemia, hypotension, not for pregos.
Monitor: azotemia, BP, potassium |
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Term
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Definition
MOA: B1 selective block
Ind: PS, SAS, HCM, SV and ventricular arrhythmias, SHT
Drugs: don't combo w/ Ca channel blocker
Effects: negative ino/chronotrope, never 100% selective, bronchoconstriction, vasoconstriction |
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Term
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Definition
MOA: Blocks Na/K ATPase pump, increases intracellular Ca by Na/Ca exchanger
Ind: DCM, systolic dysfunction, atrial fib
Drugs: inc. conc: quinidine, aspirin, macrolides, chloramphenicol. dec conc: GI drugs, phenobarb
Effects: positive inotrope, neg chronotrope, narrow TE, anorexia, wt loss, v/d, collapse, seizures, death, arrhythmias, hypokalemia
Monitoring: Check digoxin levels in 8 days, 8 hrs post pill and the goal serum level is 0.8 ng/mL |
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Term
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Definition
MOA: inc Ca/troponin-C interaction
Ind: DCM/systolic dysfunction, CHF
Drugs: none known
Effects: positive inotrope, poss. arrhythmogenic, anti-inflammatory, + lusitrope, dec platelet aggregation |
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Term
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Definition
MOA: Ca channel blocker
Ind: diastolic dysfunction, SV tachyarrythmias, pressure overload
Drugs: w/ Bblock - additive
Effects: neg ino/chronotrope, hypotension (inappetance, nausea), bradycardia, exercise intolerance, weakness, avoid with systolic dysfunction. |
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Term
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Definition
MOA: competitive antagonism of aldosterone
Ind: refractory CHF
Drugs: effect digoxin clearance
Effects: weak diuretic, hyperkalemia, anti-myocardial remodeling, facial pruritis in cats |
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Term
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Definition
MOA: Na channel blocker, Ib, shortens AP
Ind: ventricular arrythmias, local
Drugs:
Effects: Anti-arrhythmogenic, cat and goat sensitivity, local anesthetic, potentially proarrhythmic |
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Term
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Definition
MOA: Na channel blocker, Ib, shortens AP
Ind: ventricular arrhythmias
Drugs:
Effects: anti-arrhythmogenic, GI side effects, potentially proarrhythmic |
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Term
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Definition
MOA: potassium channel blocker, Beta blocker
Ind: SV and ventricular arrhythmias, Boxer ARVC
Drugs: don't combo w/ Ca channel blocker
Effects: Anti-arrhymogenic, potentially proarrhythmic |
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Term
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Definition
MOA: potassium channel blocker
Ind: refractory arrhythmias
Drugs:
Effects: Anti-arrhymogenic, potentially proarrhythmic, skin discoloration, pulmonary fibrosis, hepatopathy, thyroid level effects |
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Term
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Definition
MOA: Na channel blocker, Ia, prolongs AP
Ind: Ventricular arrythmias, SV arrythmias
Drugs:
Effects: Anti-arrhymogenic, potentially proarrhythmic, GI |
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Term
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Definition
MOA: dose dependent stimulation of B1, B2>a, DA1
Ind: ER/ICU, decomp DCM, CHF, hypotension, bradycardia
Drugs: MAO inhibitor
Effects: weak diuretic, + inotrope, tachycardia, hypertension, arrhythmias |
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Term
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Definition
MOA: dose dependent stimulation of B1>B2>a
Ind: ER/ICU, decomp DCM, CHF, hypotension, bradycardia, greater +inotrope effects
Drugs: MAO inhibitors
Effects: + inotrope, tachycardia, hypertension, arrhythmias |
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Term
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Definition
MOA: B2 selective agonist
Ind: sinus arrest, AV block
Effects: tachycardia
Drugs:
Effects: |
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Term
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Definition
MOA: irreversibly inhbits ADP binding, prevents activation and aggregation
Ind: PTE, saddle thrombus
Drugs: inc bleeding w/ anticoag
Effects: inhibit platelet activation and aggregation, thrombocytopenia |
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Term
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Definition
MOA: Irreversible acetylation of COX-1, interferes with thromboxane synthesis
Ind: PTE, saddle thrombus
Drugs: inc bleeding w/ anticoag
Effects: Inhibit platelet activation. Anti-inflammatory, PG inhibition at higher doses |
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Term
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Definition
MOA: Na channel blocker, Ia, prolongs AP
Ind: SV arrythmias, Afib, horses
Drugs: many.
Effects: Anti-arrhymogenic, potentially proarrhythmic, colic, founder, collapse |
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Term
| Dog with DCM and atrial fibrillation |
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Definition
Pimobendan, enalapril, diltiazem
Monitor: echo, ECG, Azotemia, potassium, BP |
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Term
| horse with atrial fibrillation |
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Definition
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Term
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Definition
lasix, enalapril, +/- pimobendan
Monitor: radiographs, azotemia, potassium, BP |
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Term
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Definition
lasix, enalapril, oxygen, sedation if necessary. Add diltiazem or atenolol after CHF resolved.
Monitor: azotemia, BP, potassium, rads/echo |
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Term
| cat with renal failure and CHF |
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Definition
| lasix, enalapril, lowest doses possible, cat has to breathe first. |
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Term
| dog with refractory heart failure |
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Definition
| lasix + hydrochlorothiazide (sequential nephron blockade), enalapril, pimobendan |
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Term
| dog with acute fulminant CHF |
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Definition
| dopamine/dobutamine, lasix, enalipril, pimobendan, OXYGEN |
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Term
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Definition
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Term
| horse with aortic regurg and CHF |
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Definition
| Lasix, enalipril, digoxin? |
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Term
| dog with ventricular tachycardia during splenectomy |
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Definition
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Term
| Boxer with recently diagnosed ARVC |
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Definition
Sotalol for maintenance, lidocaine for emergency
Monitor with holter monitor (ECG) |
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