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Blood
Chapter 10 A&P
42
Anatomy
12th Grade
01/27/2014

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Term
What type of tissue is blood?
Definition
Connective
Term
Formed elements
Definition
Living blood cells
Term
Plasma
Definition
Non living fluid matrix of the blood
(90% water)
Term
Erythrocytes
Definition
Red blood cells that function in oxygen transport & comprise the reddish mass at the bottom of the centrifuge
Term
Buffy coat
Definition
Thin, whitish layer between formed elements and plasma, made of leukocytes and platelets
Term
Platelets
Definition
Cell fragments tht function in the clotting process
Term
Leukocytes
Definition
White blood cells that act in various ways to protect the body
Only complete cells in body
Term
Blood volume
Definition
45% erythrocytes (hematocrit)
<1% WBC/platelets
55% plasma
Term
Plasma proteins
Definition
Most abundant solutes in plasma, mostly made by the liver
Term
Albumin
Definition
Plasma protein that contributes to the osmotic pressure of the blood; keeps water in blood stream.
Term
What is stimulated when blood becomes too alkaline/acidic?
Definition
Both the respiratory system and kidneys
(restore levels to 7.35-7.45)
Term
Anucleate
Definition
Lacking a nucleus.
Example: RBC's
Term
Hemoglobin
Definition
Iron-containing protein, transports the bulk of oxygen as it is carried in blood.
Term
neutrophil
Definition
3000-7000; active phagocytes with increasing numbers during infection
Term
eosinophil
Definition
100-400; kill parasitic worms, increase during allergy attack, might phagocytize antigen-antibody complexes & inactivate inflammatory chemicals.
Term
basophil
Definition
20-50; granules containing histamine that is discharged at sites of inflammation.
Term
monocyte
Definition
100-700;phagocytes that become microphages--long term clean up crew. increase in numbers during chronic infections.
Term
lymphocyte
Definition
1500-3000; part of immune system, produces anti-bodies. involved in graft rejection, fighting tumors and viruses, and activating B lymphocytes.
Term
megakaryocyte
Definition
platelets; rupture to release thousands of "pieces" that seal themselves off from surrounding fluid.
Term
diapedesis
Definition
Passage of blood cells through intact vessel walls into the tissues
Term
PF3
Definition
Phospholipid that coats surfaces of platelets to form an activator that triggers clotting cascade
Term
prothrombin activator
Definition
Converts prothrombin (in plasma) to thrombin (enzyme)
Term
fibrinogen
Definition
Joins thrombin to form hairlike molecules of fibrin
Term
Homestasis
Definition
Stoppage of blood fluid; result of break in blood vessel
Vascular spasms
Platelet plug formation
Coagulation
Term
Vascular spasms
Definition
Platelets secrete serotonin causing spasms that narrow the blood vessel and decrease blood loss
Term
Platelet plug formation
Definition
Collagen fibers exposed
Platelets become sticky &release pf3
Pile up to form plug
Term
Coagulation
Definition
Injured tissue releases TF
PF3 reacts with TF clotting proteins and calcium ions to trigger clotting cascade.
Term
Thrombin
Definition
Joins fibrinogen proteins into hairlike fibrin
Forms mesh work, basis of clot, to trap RBCs
Term
Which organs dispose of dead RBCs?
Definition
Liver and spleen
Term
Thrombus
Definition
Clot in unbroken blood vessel , can be deadly
Term
Embolus
Definition
Thrombus that breaks away and floats freely in bloodstream
Can clog vessels in critical areas like brain.
Term
Thrombocytopenia
Definition
Platelet deficiency
Term
Hemophilia
Definition
Normal clotting factors are missing
Term
Fibrin
Definition
Forms meshwork that traps RBC's and forms basis of clotting
Term
When the number of RBC's increases, viscosity ____.
Definition
Increases
Term
Anemia
Definition
A decrease in the oxygen-carrying ability of the blood, for whatever reason
Term
Anemia may result in?
Definition
Low # of RBC's
Abnormal hemoglobin content in RBC's
Term
Sickle cell anemia
Definition
Hemoglobin becomes spikey and sharp, rupturing easily and damming up in small blood vessels.
Term
Polycythemia
Definition
An excessive or abnormal increase in the number of erythrocytes
Term
Positive chemotaxis
Definition
WBC's can locate areas of tissue damage and infection by responding to chemicals from damaged cells
Term
Ameboid motion
Definition
WBCs move through tissue by forming flowing cytoplasmic extensions
Term
Leukocytosis
Definition
WBC count above 11,000
Indicates infection is stewing
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