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blood
blood notecards
42
Anatomy
Undergraduate 4
02/08/2012

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Term
contents of blood plasma (3)
Definition
water, proteins, other solutes
Term
contents of buffy coat
Definition
platelets, leukocytes
Term
normal hematocrit value
Definition
~45%
Term
normal blood plasma value
Definition
~55%
Term
buffy coat normal value
Definition
<1%
Term
fucking DEFINE: homeostasis
Definition
keeping many of the constituents of blood plasma within narrow limits
Term
Do RBC have a nucleus? do they have organelles?
Definition
no and fucking NO
Term
what is the structure function relationship in regards to
Definition
the structure of the RBC allows it to have more S.A. which helps it bind moar O2
Term
explain how cyanide and CO poisoning works
Definition
both cyanide and CO bind the iron in heme, which prevents the hemoglobin from carrying 02. our body can't do fucking SHIT with CO or cyanide
Term
explain the entire fucking process of hemopoeisis. where it becomes anuclear
Definition
Hemocytoblast (blood stem cell)>myeloid stem cell>progenitor cells, blast cells.
>Bone marrow> proerythroblast>erythroblast>normoblast (nucleus ejected here)>reticulocyte>circulation>mature RBC
Term
3 factors needed for erythropoesis (I.V.F)
Definition
iron, vitamin b12, folic acid
Term
what causes a hemocytoblast to commit to erythrocyte path
Definition
the whoremoan epo
Term
what is the lifespan of an RBC
Definition
120 days
Term
what will stimulato EPO-esis, explain the cycle
Definition
decreased blood o2>kidney ^regs epo secretion>bone marrow is like wtf ok guess I'll make moar RBCs>moar RBCs released into blood
Term
what is the general definition for anemias
Definition
decreased 02 to the tissues
Term
3 reasons why an anemic pt would actually have less o2 in their body
Definition
overall fewer RBCs, low hemoglobin (iron deficiency anemia), abnormal HB (sickle cell, thalessemia B)
Term
Thalassemia B-abnormal amounts of what? and the RBCs have what 2 qualities?
Definition
abnormal amounts of HB. the RBCs are MIRCROcytic (small), and hypoCHROMIC (pale).
Term
sickle cell anemia, also what causes it, and what the RBCs "more"
Definition
abnormally shaped blood cells can't move through bloodstream easily, this makes it harder to get o3 to tissue.
cause. what causes it is a wrong AA results in abnormal HBs

the RBCs are moar fragile "hemolytic"
Term
polycythemia, doing what gives this condition
Definition
^rbc count blood doping
Term
vascular spasm
Definition
happens when a vessel is damaged
Term
define degranulation
Definition
release of chemicals platlets, which leads to platlet aggregation
Term
5 chemicals favoring plug formation
Definition
1.von willebrand factor
2. serotonin
3. ADP
4.TxA2 (thrombaxane)
5. clotting factors
Term
2 chems limiting clot formation
Definition
PGi2 (prostacyclin)

NO
Term
draw out clotting pathway after thrombib
Definition
Thrombin>activates fibrinogen into loos fibrin and XIII into XIIIa>XIIIA actives loose fibrin into STABILIZED fibrin
Term
what exactly is a clot
Definition
a FIBRIN polymer
Term
what factor comes from activated platelets that is an important cofactor for clotting
Definition
PF-platelet factor
Term
intrinsic pathway-intrinsic to what, what gets activated due to contact to what?
Definition
intrinsic to blood, factor XII is activated due to CONTACT to collagen
Term
extrinsic pathway-requires what from where
Definition
requires tissue factor from subendothelial cells in vessel wall
Term
common pathway-where do the 2 pathways converge
Definition
they both converge on the activation of factor x
Term
is the intrinsic or extrinsic pathway activated 1st?
Definition
EXtrinsic
Term
when the extrinsic pathway gets activated what gets activated next on what pathway, what does this allow the intrinsic pathway to do without contact activation and factor XII
Definition
thrombin's positive feedback effects on the intrinsic pathway

it allows the intrinsic pathway to be activated without contact activation and factor XII
Term
liver's role in blood clotting?
Definition
bile salts>Vitamin K>V.K. in bloof makes clotting factors.
Term
procoagulant function
Definition
1cleaves fibrinogen to fibrin
2activates clotting factors
3stimulates platelet activation
Term
anticoagulent function
Definition
inactivates clotting factor which is done by activating protein c
Term
antithrombin-comes from? weak or strong? made stronger where?
Definition
liver, weak, stronger with heperain arounf
Term
heparin-what kind of cells are these pretty much
Definition
mast cells
Term
thrombomodulin
Definition
receptor that binds thrombin and activates protein C-->INactivates 2 clotting factors
Term
fibrinloytic system
Definition
Tissue plasminogen activator (TPA)
Term
plasmin turns fibrin into?
Definition
soluble fibrin gragments
Term
what is retraction?
Definition
a contractile process
Term
thromboembolytic conditions-a clot forms..if it breaks loose its a what? whats it called if its lodged in the lungs
Definition
clot thats loose is an embolus, in lungs its a pulmonary embolism
Term
if there is a patent foramen ovale..where might an embolism occur?
Definition
in the arterial systemic system
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