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Details

Biologics
pharmacology
6
Veterinary Medicine
Professional
10/13/2021

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
Lokivetmab
Definition

-caninized anti-canine IL-31

-anti-cytokine mAb available in dogs

Term
IL-5 vaccine for IBH in horses- what is the MOA?
Definition

-IL-5 is a key cytokine for eosinophils

-improved IBH clinical signs and all horses developed anti-eIL-5 auto antibody titers (mean course of eosinophil level was reduced compared to placebo)

Term
Monoclonal antibodies MOA
Definition

-target a specific antigen on the cell surface (via antibody-antigen binding)

-each antibody is produced by a specific B cell line

-used for the treatment of cancer and various auto-immune diseases

-During the cell cycle, a mutated cell may occur due to environmental or genetic factors (cancerous cells occur as the cell divides uncontrollably)

-Monoclonal antibodies used to treat cancer target specific antigens that are overexpressed on the surface of cancer cells (results in apoptosis, MAC complexes via complement mediated cell lysis or attract other immune cells to attack the cancer cells)

-A lot of the cell receptors promote growth and proliferation that are targets for mAbs

-cancer mAbs are administered IV- destroyed in GI tract if taken orally

-Human monoclonal antibody suffix ("UMAB")

-Chimeric monoclonal antibody suffix ("XIMAB")-more likely to be recognized as foreign and promote hypersensitivity reactions

-Humanized monoclonal antibodies produced by other species ("Zumab")- less likely to cause hypersensitivity reactions compared to Chimeric mAbs

Term
Dupilumab is a monoclonal for atopic dermatitis in humans. What is its target?
Definition
The IL-4 receptor, which inhibits action of both IL-4 and IL-13
Term
Apoquel cytokine targets
Definition
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Term
Cytopoint cytokine targets
Definition
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