Term
|
Definition
inhibits cell wall synthesis
more effective against Gram + |
|
|
Term
|
Definition
bactericidal
time-dependent
post-antibiotic effect |
|
|
Term
|
Definition
| Beta-lactamases in some gram + and some Gram - bacteria |
|
|
Term
|
Definition
weak organic acid, ionized in plasma
poor to modest oral bioavailability
wide extracellular distribution but not good intracellular penetration
good penetration in extracellular fluids
penetration into deep tissues enhanced by inflammation
renal elimination with high urine concentrations |
|
|
Term
|
Definition
Type A - dose dependent
safe with wide margin of safety
Type B - allergic
usually mild immediate reactions but rare anaphylaxis
delayed reactions
cross-reactivity between B-lactams but very unlikely (10%) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Carbapenems, Monobactams Clinical Usage |
|
Definition
not to be used empirically
not to be first line
use only for positive culture and sensitivity |
|
|
Term
| Carbapenems, Monobactams Activity |
|
Definition
bactericidal
time-dependent
post-antibiotic effect |
|
|
Term
|
Definition
widest spectrum of action
Gram +, Gram -, aerobes, anaerobes, B-lactamase + |
|
|
Term
|
Definition
most Gram -, but not Gram +
resistant against some B-lactamases |
|
|
