Term
| Campylobacter spp. - source |
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Definition
| -normal commensals of gut esp +/- repro tract |
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Term
| Campylobacter spp. - main dz |
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Definition
associated w. area of commensals
i.e. intestinal (diarrhoea) or genital (infertility / abortion) |
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Term
| Campylobacter jejuni - source |
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Definition
-normal gut flora in many mammals and birds
NB: shares genetic material w. C.coli - some bact. are 50:50! |
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Term
| Campylobacter jejuni - main dz |
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Definition
main problem is enteritis in man
-also abortion in sheep, cattle, dogs, mastitis in cows |
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Term
| Campylobacter jejuni - transmission |
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Definition
-contaminated food esp poultry (poultry are carriers)
-raw/unpasteurised milk
-direct contact w. puppies
Infective dose = 500 bact (v. low) - there are 10e7/g faeces! 50% of chickens have gut carriage and spread in processing plant |
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Term
| Campylobacter jejuni - dz. in man |
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Definition
-1-7 days enteritis, dysentery, fever
(biggest cause of food poisoning)
~1% of cases develop Guillain Barre syndrome (peripheral neuritis/neuropathy - poss. loss of limb use) |
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Term
| Campylobacter fetus ss venerealis - source |
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Definition
-obligate parasite in bovine genital tract
-veneral transmission |
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Term
| Campylobacter fetus ss venerealis - main dz |
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Definition
bovine abortion / infertility
(NB: in humans inf. is systemic) |
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Term
| Campylobacter fetus ss venerealis - pathogenesis / sequence of events |
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Definition
bull is sublinical carrier in prepuce) --> cow --> inflam of uterus / oviducts --> resorption / 10% early abortion (body is trying to throw eveything out!)
--> persistent infection / inflam and herd infertility at 6-7 mnths --> some clear infection w. immunity for 4 years, 1/3 get chronic infection of cervix/vagina and require tx |
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Term
| Campylobacter fetus ss venerealis - immunity |
|
Definition
after abortion / resorption / inflam:
-some clear infection w. immunity for 4 years
-1/3 get chronic infection of cervix/vagina and require tx |
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Term
| Campylobacter fetus ss venerealis - dx |
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Definition
-PCR of semen
-Microscopy and culture (preputial wash, vaginal mucus, placenta / foetus)
not gram stain, use immunofluoresence or culture
-serology - look for vaginal IgA (good), agglutination test or ELISA |
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Term
| Campylobacter fetus ss venerealis - control |
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Definition
-screnn bulls, remove carriers and give antibiotics
-AI from clean bulls
-elimination from herd IS possible
-vacc can be used therapeutically and prophylatically |
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Term
| Campylobacter fetus ss fetus - source |
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Definition
-normal gut flora, mainly sheep
-oral transmission from aborted material / placenta |
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Term
| Campylobacter fetus ss fetus - main dz |
|
Definition
ovine abortion and enteritis
(entertitis / systemic in man) |
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Term
| Campylobacter fetus ss fetus - sequence of events |
|
Definition
| gut --> penetration --> blood --> late term placenta --> inflam / late term abortion --> no carriage or subsequence abortion |
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Term
| Campylobacter fetus ss fetus - diagnosis |
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Definition
| similar to Campylobacter fetus spp venerealis - i.e. not gram stain, immunofluorescence, culture |
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Term
| Campylobacter fetus ss fetus - control |
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Definition
-can NOT eliminate
-antibiotics and vaccines
-clean up aborted material and placenta |
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Term
| Campylobacter fetus ss venerealis and ss fetus - comparison |
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Definition
-ss. venerealis causes abortion in cattle ss. fetus causes abortion in sheep
-ss. fetus can also cause enteritis
-ss. venerealis is obligate para. of bovine genital tract
-ss. fetus is a gut commensal of sheep
-ss. veneralis can be eliminated from a herd, ss. fetus can not |
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Term
| Campylobacter jejuni and C. fetus - comparison |
|
Definition
-C.jejuni main dz. is enteritis in man
-C. fetus main dz in abortion in cattle and sheep |
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