Term
| Different Types of Nucleic Acid Disruptors |
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Definition
-DNA replication inhibitors
- RNA synthesis inhibitors
-DNA damaging agents |
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Term
| DNA replication inhibitors |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Approved Fluoroquinolones |
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Definition
Enrofloxacin
Ciprofloxacin
Marbofloxacin |
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Term
| Fluoroquinolones mechanism of action |
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Definition
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Term
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Definition
Bactericidal, concentration dependent;
CAN LOSE EFFICACY if too high a concentration!! |
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Term
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Definition
| Aerobic Gram - ; Extra and intracellular bacteria; variable against Gram + (terrible against strep) |
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Term
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Definition
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Term
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Definition
| mainly renal elimination (some liver) |
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Term
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Definition
FQ - DNA replication inhibitor.
The active form of enrofloxacin
Only FQ with liver metabolism |
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Term
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Definition
FQ- DNA Synthesis Inhibitor
The active form is ciprofloxacin |
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Term
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Definition
| FQ- DNA synthesis inhibitor |
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Term
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Definition
well absorbed orally in monogastrics (esp. dogs and cats). Oral absorption is decreased by di and trivelent cations.
--extra and intracellular. Good penetration into fluids and deep tissues. |
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Term
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Definition
Relatively Safe drugs; mild GI distrurbances; articular damage in growing juveniles. Tendon/ligament toxicity.
--Dose Dependent reactions. Retinal degenration, neurotoxicity (decrease seizure threshold). Avoid in epileptic animals. Rapid resistance reaction. |
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Term
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Definition
Appropriate Use of the Drug range.
Too low: resistance and failure of tx.
Too high: lowered efficacy
Concentration dependent: requires a relatively high Cmax: MIC ratio.
--off label use banned in food animal! |
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Term
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Definition
| RNA transcription inhibitors |
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Term
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Definition
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Term
| Example of Nitroimadazole |
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Definition
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Term
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Definition
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Term
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Definition
Bactericidal; concentration dependent.
--mostly aerobic Gram +; extra and intracellular. Obligate anaerobes are resistant. |
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Term
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Definition
Antagonism with other bacteriostatics
Liver enzyme inducer. will modify PK of various drugs |
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Term
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Definition
Relatively safe; teratogenic (banned in food animals pregnant animals!)
--Hepatotoxicity---reported in dogs |
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Term
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Definition
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Term
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Definition
| DNA damage; Bactericidal; time or concentration dependent (depends on microbe). Only in anaerobic conditions |
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Term
| Metronidazole spectrum of action |
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Definition
most obligate anaerobics
Extra and intracellular bacteria |
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Term
| Metronidazole pharmacokinetics |
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Definition
well absorbed orally (not palatable).
VERY GOOD fluid and tissue penetration. Mixed hepatic and renal elimination |
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Term
| metronidazole Adverse effects |
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Definition
| relatively safe drug. Very unpalatable; alteration GI flora. Neurotoxicity at high doses. drug interactions due/to liver metabolism. Banned in food animals/pregnant animals/avoid long term use. Carcinogenic/Teratogenic. |
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