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-Cell wall synthesis inhibitors
-Bactericidal
-Time-dependent
-Mainly active against Gram +
- Highly nephrotoxic when used systemically
- Used topically |
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- Alter ion transport across membrane cell pH, death
- Marked toxicity
- Used as anticoccidialis or feed promotants |
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| Glycopeptides, Polymyxins, Bacitracin, Ionophores |
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| Inhibits cell wall synthesis; bactericidal; both time and concentration depedent; ONLY Gram +; Resistance Emerging Dangerously!!! |
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Definition
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| Warnings about Glycopeptides |
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Definition
| Banned in Food Animal; never to be used empirically. Used against resistant Gram + if no other option! |
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| Polymyxin B Mechanism of Action |
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Definition
Disruptor of cell membranes and Endotoxin effect-Bactericidal. Concentration dependent.
ONLY Gram - (aerobes and anaerobes) including Pseaudomonas. |
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Term
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Definition
| Not absorbed orally; slow renal elimination. nephrotoxic or neurotoxic when used systemically. |
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