Term
|
Definition
| disrupts mitotic spindle causing mitotic arrest in fungal cells |
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Term
|
Definition
| CATS-leukopenia, anemia, inc hepatic enzymes, neurotoxicosis, teratogenic |
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Term
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Definition
| Binds ergosterol in fungal cell membrane and makes it more permeable so the cell goodies leak out=cell death |
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Term
|
Definition
Dose dependent nephrotoxicity***ie:inc BUN/CREA
Plebitis, fever, v/d |
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Term
|
Definition
| Binds ergosterol in fungal cell membrane and makes it more permeable so the cell goodies leak out=cell death |
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Term
|
Definition
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Term
|
Definition
| Candida. Oral and topical** antifungal but is not absorbed orally |
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Term
|
Definition
Voriconazole
Fluconazole
Itraconazole
Posaconazole
"V-FIP" |
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Term
|
Definition
Miconazole
Eniloconazole
Clotrimazole
Ketoconazole
"MECK" |
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Term
| Diff bt Triazoles and Imidazoles |
|
Definition
| Triazoles=less effect on mammal sterol synthesis, longer elimination Imidazoles=More endocrine adverse effects, affects mammal sterol synthesis |
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Term
|
Definition
| inhibit ergosterol synthesis in the fungal cell membrane by inhibition of P450-dependent enzyme |
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Term
|
Definition
Most commonly-GI effects
Elevated liver enzymes/hepatotoxicity**
Teratogenic
also inhibits mammalian p450 enzymes |
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Term
|
Definition
GI>CNS>skin
mild hepatic enzyme elevations |
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Term
|
Definition
Elevated liver enzymes/hepatotoxicity
but better for long term than ketoconazole |
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Term
|
Definition
| unknown, but liver enlgment seen in one study in dogs |
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Term
|
Definition
| Inhibits squalene epoxidase to decrease synthesis of ergosterol in fungal cell membranes |
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Term
|
Definition
Facial dermatitis in cats
elevated liver enzymes in dogs |
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Term
|
Definition
| chitin synthesis inhibitor |
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Term
|
Definition
| Converted to active 5-FU and incorporated into RNA=disrupts protein synthesis, or inhibits DNA synthesis |
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Term
|
Definition
| anemia, leukopenia, thrombocytopenia if 5-FU conversion occurs in GIT |
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Term
|
Definition
| inhibit fungal growth (per Fajt) stimulates host immune response or inc elimation of fungi through skin or hair (per red book) |
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Term
|
Definition
| Enilconazole, clotrimazole, miconazole, natamycin, nystatin |
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Term
|
Definition
| Binds ergosterol in fungal cell membrane and makes it more permeable so that the cell goodies leak out=cell death |
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Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
tx influenza virus
also NMDA antagonist so may be effective adjunct analgesic |
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Term
|
Definition
antiviral
parenteral antineoplastic for dogs and cats |
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Term
|
Definition
|
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Term
|
Definition
| TX-herpes viruses in cats=prevents spread |
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Term
|
Definition
ie:tamiflu
TX-influenza
banned in poultry |
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Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Major protozoal pathogens in veterinary medicine |
|
Definition
| Eimeria, isospora, toxoplasma, leishmania, tritrichomonas, sarcocystis, babesia |
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Term
| Drugs that bind ergosterol |
|
Definition
Amphotericin B
Nystatin
Natamycin
|
|
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Term
|
Definition
Zidovudine
Interferon alpha |
|
|
Term
| Antivirals for Herpesvirus |
|
Definition
Idoxuridine
Lysine
Acyclovir |
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Term
|
Definition
Toltrazuril
Metronidazole
Decoquinate
Albendazole
Monensin
Doxycycline
Pyrimethamine
Amprolium |
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