Term
|
Definition
Used in treatment of allergy, nausea, vomiting
e.g. Cyproheptadine, Chlorphenamine |
|
|
Term
|
Definition
| H1 antagonist used in tx of feline asthma (prophalatic) |
|
|
Term
|
Definition
H1 antagonist, i.e. anti-inflam drug.
Used for allergic skin reactions, scratching, mild sedation |
|
|
Term
| Polysulfated Glycosaminoglycan (PSGAG) |
|
Definition
| A chondroprotectice drug, inhibits PGE2 and so inhibits vasodil. and hyperalgesia |
|
|
Term
|
Definition
a component of synovial fluid and articular cartilage which inhibits PGE2 synthesis and so so inhibits vasodil. and hyperalgesia
-used in tx of horses w. osteoarthritis |
|
|
Term
|
Definition
non-steroidal antiinflam drugs
Actions - antinflam, antipyretic, analgesia
Primary mechanism is inhibition of COX and so decr. PG and TXA synthesis |
|
|
Term
|
Definition
A salicylate NSAID - COX-1 selective inhibitor - (irreversible) so decr. PGs, PGI2, TXA
-antiplatelet aggregation < analgesic and antipyretic action < AI action |
|
|
Term
|
Definition
A NSAID but no AI action!
-not sure of mechanism, poss inhibits a COX-3 enzyme? |
|
|
Term
|
Definition
| NSAID - moderate AI action, good antipyrexic and analgesic action |
|
|
Term
|
Definition
NSAID - some COX-2 selectivity
-analgesic and antipyrexic action
-horses and dogs |
|
|
Term
|
Definition
NSAID - some COX-2 selectivity (less than carprofen)
-commonly used for H in relief of pain and inflam
-used in dogs fro chronic osteoarthritis (care w. toxicity) |
|
|
Term
|
Definition
| NSAID - some COX-2 selectivity |
|
|
Term
|
Definition
NSAID - COX-2 selective
-COS-2 selective agents used in patience w. high risk of GI ulcer/bleeeding or in extreme pain
NB: not used in patients w. ischaemic H dz or cerebrovasc. dz. and all must be monitored closely |
|
|
Term
|
Definition
-anti-inflammatories, w. immunosupp. action at high doses
-inhibit COX-2 so inhibit inflam production of PGs, PGI2, TXA
-induce lipocortin which inhibits phospholipase A2
-decr. levels of complement protein in plasma
-decr. the generation of induced NO
-decr. histamine release from basophils
-decr. IgG production |
|
|
Term
|
Definition
GCC - used for asthma (in cats esp) and autoimmune dz at high doses
- no affinity for mineralocorticoids so doesn't affect water balance (advantage) |
|
|
Term
|
Definition
| low potency GCC - used for skin dz, HS reactions |
|
|
Term
|
Definition
V. potent GCC
- no affinity for mineralocorticoids so doesn't affect water balance (advantage) |
|
|
Term
|
Definition
GCC -most effective immunosuppressant
-inhibits calcineurin activation (enzyme in T-cells involved in the production of IL2) so IL2 not activated |
|
|
