Term
| List the common allergic skin issues from most common to least common. |
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Definition
| -atopy > flea bite hypersensitivity/irritant contact dermatitis > adverse rxn to food > allergic contact dermatitis |
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Term
| How does atopy change the rate of food allergies? |
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Definition
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Term
| What type of hypersensitivity rxn is atopy? |
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Definition
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Term
| What immunoglobulin mediates atopy? |
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Definition
-IgE
-causes mast cells to release |
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Term
| What are the major concerns with atopic dogs? |
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Definition
-defect in lipid layer of epidermic barrier
-predisposed to recurrent superficial dermal infections |
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Term
| What are papules that incorporate hair follicles suggestive of? |
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Definition
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Term
| What are epidermal collarets highly suggestive of? |
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Definition
| -superficial bacterial folliculitis |
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Term
| How do we manage stage II atopy? |
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Definition
-dietary food trial
-allergy testing: Ag injection therapy
-Systemic management: corticosteroids, Cyclosporine, OClacitinib
-Topical therapy: FA (oatmeal shampoo), humectants, epidermal barrier restoration |
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Term
| Describe a typical canine dietary food trial. |
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Definition
-limited ingredient diet
-hydrolyzed protein diet: best but least palpable
-strictly enforced
-at least 809 weeks
-compliance is an issue!!! |
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Term
| Describe the efficacy of allergy testing in dogs. |
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Definition
| -reduces clinical signs by 50% or more in 60% of dogs |
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Term
| What are the two forms of allergy testing in dogs? Which is the gold standard? |
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Definition
-IDST: expense, withdrawal of steroids, experience, normal skin to test
-Serum allergy test: easy to perform, withdrawal of steroids is less of an issue, does not require normal skin, false positive rxns
-IDST is the gold standard |
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Term
| WHich age group of dogs is best for allergy testing? |
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Definition
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Term
| Discuss the systemic medical management using corticosteroids? |
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Definition
-effective and inexpensive
-side effects can be severe depending on dose and duration |
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Term
| Describe systemic medical management using Cyclosporine (Atopica - Novartis) |
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Definition
-several beneficial effects in atopic dogs
-effective in 6-70% of stage III cases
-expensive
-side effects: vomiting, secondary infections
-monitoring drug levels |
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Term
| How does Oclacitinib work? what is it used for? Time of onset? |
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Definition
-Selective Janus Kinase inhibitor: inhibits IL-31 and other cytokines
-inhibits pruritus and inflammation
-quick onset and lasts about 8-10 |
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Term
| What side effects can occur due to Oclacitinib? |
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Definition
-soft stools during day 1-3: self limiting
-immunosuppression: secondary infections
-leukopenia |
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Term
| Describe the distribution of atopy. |
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Definition
| -face, ears, feet, distal limbs, ventral abdomen and groin |
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Term
| True or False: Cats often get atopy. |
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Definition
| -FALSE, cats rarely get atopy |
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